138 related articles for article (PubMed ID: 9148943)
1. Amplification of the DNA repair gene O6-methylguanine-DNA methyltransferase associated with resistance to alkylating drugs in a mammalian cell line.
Tano K; Dunn WC; Darroudi F; Shiota S; Preston RJ; Natarajan AT; Mitra S
J Biol Chem; 1997 May; 272(20):13250-4. PubMed ID: 9148943
[TBL] [Abstract][Full Text] [Related]
2. Transfection and expression of human O6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents.
Kaina B; Fritz G; Mitra S; Coquerelle T
Carcinogenesis; 1991 Oct; 12(10):1857-67. PubMed ID: 1657427
[TBL] [Abstract][Full Text] [Related]
3. Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent.
Maze R; Carney JP; Kelley MR; Glassner BJ; Williams DA; Samson L
Proc Natl Acad Sci U S A; 1996 Jan; 93(1):206-10. PubMed ID: 8552605
[TBL] [Abstract][Full Text] [Related]
4. Inducibility of the DNA repair gene encoding O6-methylguanine-DNA methyltransferase in mammalian cells by DNA-damaging treatments.
Fritz G; Tano K; Mitra S; Kaina B
Mol Cell Biol; 1991 Sep; 11(9):4660-8. PubMed ID: 1875945
[TBL] [Abstract][Full Text] [Related]
5. Expression of human O6-methylguanine-DNA methyltransferase in a DNA excision repair-deficient Chinese hamster ovary cell line and its response to certain alkylating agents.
Wu ZN; Chan CL; Eastman A; Bresnick E
Cancer Res; 1992 Jan; 52(1):32-5. PubMed ID: 1727384
[TBL] [Abstract][Full Text] [Related]
6. Retrovirus-mediated transfer of the human O6-methylguanine-DNA methyltransferase gene into a murine hematopoietic stem cell line and resistance to the toxic effects of certain alkylating agents.
Wang G; Weiss C; Sheng P; Bresnick E
Biochem Pharmacol; 1996 May; 51(9):1221-8. PubMed ID: 8645346
[TBL] [Abstract][Full Text] [Related]
7. Induction of the alkyltransferase (MGMT) gene by DNA damaging agents and the glucocorticoid dexamethasone and comparison with the response of base excision repair genes.
Grombacher T; Mitra S; Kaina B
Carcinogenesis; 1996 Nov; 17(11):2329-36. PubMed ID: 8968045
[TBL] [Abstract][Full Text] [Related]
8. Reversal of 1,3-bis(2-chloroethyl)-1-nitrosourea-induced severe immunodeficiency by transduction of murine long-lived hemopoietic progenitor cells using O6-methylguanine DNA methyltransferase complementary DNA.
Maze R; Kapur R; Kelley MR; Hansen WK; Oh SY; Williams DA
J Immunol; 1997 Jan; 158(2):1006-13. PubMed ID: 8993023
[TBL] [Abstract][Full Text] [Related]
9. Conformational change in human DNA repair enzyme O6-methylguanine-DNA methyltransferase upon alkylation of its active site by SN1 (indirect-acting) and SN2 (direct-acting) alkylating agents: breaking a "salt-link".
Oh HK; Teo AK; Ali RB; Lim A; Ayi TC; Yarosh DB; Li BF
Biochemistry; 1996 Sep; 35(38):12259-66. PubMed ID: 8823159
[TBL] [Abstract][Full Text] [Related]
10. Role of O6-methylguanine-DNA methyltransferase in the resistance of pancreatic tumors to DNA alkylating agents.
Kokkinakis DM; Ahmed MM; Delgado R; Fruitwala MM; Mohiuddin M; Albores-Saavedra J
Cancer Res; 1997 Dec; 57(23):5360-8. PubMed ID: 9393761
[TBL] [Abstract][Full Text] [Related]
11. Regulation of expression of the DNA repair gene O6-methylguanine-DNA methyltransferase via protein kinase C-mediated signaling.
Boldogh I; Ramana CV; Chen Z; Biswas T; Hazra TK; Grösch S; Grombacher T; Mitra S; Kaina B
Cancer Res; 1998 Sep; 58(17):3950-6. PubMed ID: 9731508
[TBL] [Abstract][Full Text] [Related]
12. Expression of human O6-methylguanine-DNA methyltransferase in Chinese hamster ovary cells and restoration of cellular resistance to certain N-nitroso compounds.
Wu Z; Chan CL; Eastman A; Bresnick E
Mol Carcinog; 1991; 4(6):482-8. PubMed ID: 1793486
[TBL] [Abstract][Full Text] [Related]
13. Expression of mammalian O6-alkylguanine-DNA alkyltransferase in a cell line sensitive to alkylating agents.
Dolan ME; Norbeck L; Clyde C; Hora NK; Erickson LC; Pegg AE
Carcinogenesis; 1989 Sep; 10(9):1613-9. PubMed ID: 2766456
[TBL] [Abstract][Full Text] [Related]
14. Constitutive expression and inducibility of O6-methylguanine-DNA methyltransferase and N-methylpurine-DNA glycosylase in rat liver cells exhibiting different status of differentiation.
Grombacher T; Kaina B
Biochim Biophys Acta; 1995 Jan; 1270(1):63-72. PubMed ID: 7827137
[TBL] [Abstract][Full Text] [Related]
15. Contribution of O6-alkylguanine and N-alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: new insights gained from studies of genetically engineered mammalian cell lines.
Kaina B; Fritz G; Coquerelle T
Environ Mol Mutagen; 1993; 22(4):283-92. PubMed ID: 8223512
[TBL] [Abstract][Full Text] [Related]
16. O6-methylguanine-DNA methyltransferase activity and induction of novel immunogenicity in murine tumor cells treated with methylating agents.
Bianchi R; Citti L; Beghetti R; Romani L; D'Incalci M; Puccetti P; Fioretti MC
Cancer Chemother Pharmacol; 1992; 29(4):277-82. PubMed ID: 1537073
[TBL] [Abstract][Full Text] [Related]
17. DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents.
Glassner BJ; Weeda G; Allan JM; Broekhof JL; Carls NH; Donker I; Engelward BP; Hampson RJ; Hersmus R; Hickman MJ; Roth RB; Warren HB; Wu MM; Hoeijmakers JH; Samson LD
Mutagenesis; 1999 May; 14(3):339-47. PubMed ID: 10375003
[TBL] [Abstract][Full Text] [Related]
18. Epigenetic regulation of the MGMT and hMSH6 DNA repair genes in cells resistant to methylating agents.
Bearzatto A; Szadkowski M; Macpherson P; Jiricny J; Karran P
Cancer Res; 2000 Jun; 60(12):3262-70. PubMed ID: 10866320
[TBL] [Abstract][Full Text] [Related]
19. Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents.
Cai S; Xu Y; Cooper RJ; Ferkowicz MJ; Hartwell JR; Pollok KE; Kelley MR
Cancer Res; 2005 Apr; 65(8):3319-27. PubMed ID: 15833865
[TBL] [Abstract][Full Text] [Related]
20. Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells.
Fontes AM; Davis BM; Encell LP; Lingas K; Covas DT; Zago MA; Loeb LA; Pegg AE; Gerson SL
Mol Cancer Ther; 2006 Jan; 5(1):121-8. PubMed ID: 16432170
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
