BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

180 related articles for article (PubMed ID: 9149373)

  • 1. Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102: structural studies on specific CYP2D6 substrate metabolism.
    Lewis DF; Eddershaw PJ; Goldfarb PS; Tarbit MH
    Xenobiotica; 1997 Apr; 27(4):319-39. PubMed ID: 9149373
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Molecular modelling of human CYP2C subfamily enzymes CYP2C9 and CYP2C19: rationalization of substrate specificity and site-directed mutagenesis experiments in the CYP2C subfamily.
    Lewis DF; Dickins M; Weaver RJ; Eddershaw PJ; Goldfarb PS; Tarbit MH
    Xenobiotica; 1998 Mar; 28(3):235-68. PubMed ID: 9574814
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Molecular modelling of human CYP2E1 by homology with the CYP102 haemoprotein domain: investigation of the interactions of substrates and inhibitors within the putative active site of the human CYP2E1 isoform.
    Lewis DF; Bird MG; Dickins M; Lake BG; Eddershaw PJ; Tarbit MH; Goldfarb PS
    Xenobiotica; 2000 Jan; 30(1):1-25. PubMed ID: 10659948
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Molecular modelling of CYP4A subfamily members based on sequence homology with CYP102.
    Lewis DF; Lake BG
    Xenobiotica; 1999 Aug; 29(8):763-81. PubMed ID: 10553718
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Molecular modelling of CYP3A4 from an alignment with CYP102: identification of key interactions between putative active site residues and CYP3A-specific chemicals.
    Lewis DF; Eddershaw PJ; Goldfarb PS; Tarbit MH
    Xenobiotica; 1996 Oct; 26(10):1067-86. PubMed ID: 8905920
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Influence of amino acid residue 374 of cytochrome P-450 2D6 (CYP2D6) on the regio- and enantio-selective metabolism of metoprolol.
    Ellis SW; Rowland K; Ackland MJ; Rekka E; Simula AP; Lennard MS; Wolf CR; Tucker GT
    Biochem J; 1996 Jun; 316 ( Pt 2)(Pt 2):647-54. PubMed ID: 8687412
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Molecular modelling of the mouse cytochrome P450 CYP2F2 based on the CYP102 crystal structure template and selective CYP2F2 substrate interactions.
    Lewis DF; Bailey PT; Low LK
    Drug Metabol Drug Interact; 2002; 19(2):97-113. PubMed ID: 12751909
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities.
    Venhorst J; ter Laak AM; Commandeur JN; Funae Y; Hiroi T; Vermeulen NP
    J Med Chem; 2003 Jan; 46(1):74-86. PubMed ID: 12502361
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The CYP2 family: models, mutants and interactions.
    Lewis DF
    Xenobiotica; 1998 Jul; 28(7):617-61. PubMed ID: 9711809
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Molecular modelling of CYP2B6, the human CYP2B isoform, by homology with the substrate-bound CYP102 crystal structure: evaluation of CYP2B6 substrate characteristics, the cytochrome b5 binding site and comparisons with CYP2B1 and CYP2B4.
    Lewis DF; Lake BG; Dickins M; Eddershaw PJ; Tarbit MH; Goldfarb PS
    Xenobiotica; 1999 Apr; 29(4):361-93. PubMed ID: 10375007
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity.
    Smith G; Modi S; Pillai I; Lian LY; Sutcliffe MJ; Pritchard MP; Friedberg T; Roberts GC; Wolf CR
    Biochem J; 1998 May; 331 ( Pt 3)(Pt 3):783-92. PubMed ID: 9560305
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A three-dimensional protein model for human cytochrome P450 2D6 based on the crystal structures of P450 101, P450 102, and P450 108.
    de Groot MJ; Vermeulen NP; Kramer JD; van Acker FA; Donné-Op den Kelder GM
    Chem Res Toxicol; 1996; 9(7):1079-91. PubMed ID: 8902262
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102.
    Lewis DF; Lake BG; George SG; Dickins M; Eddershaw PJ; Tarbit MH; Beresford AP; Goldfarb PS; Guengerich FP
    Toxicology; 1999 Nov; 139(1-2):53-79. PubMed ID: 10614688
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Molecular modeling-guided site-directed mutagenesis of cytochrome P450 2D6.
    de Graaf C; Oostenbrink C; Keizers PH; van Vugt-Lussenburg BM; van Waterschoot RA; Tschirret-Guth RA; Commandeur JN; Vermeulen NP
    Curr Drug Metab; 2007 Jan; 8(1):59-77. PubMed ID: 17266524
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Functional and structural characterisation of common cytochrome P450 2D6 allelic variants-roles of Pro34 and Thr107 in catalysis and inhibition.
    Dong AN; Ahemad N; Pan Y; Palanisamy UD; Yiap BC; Ong CE
    Naunyn Schmiedebergs Arch Pharmacol; 2019 Aug; 392(8):1015-1029. PubMed ID: 31025144
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Molecular modelling of steroidogenic cytochromes P450 from families CYP11, CYP17, CYP19 and CYP21 based on the CYP102 crystal structure.
    Lewis DF; Lee-Robichaud P
    J Steroid Biochem Mol Biol; 1998 Aug; 66(4):217-33. PubMed ID: 9744519
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Molecular modelling of lanosterol 14 alpha-demethylase (CYP51) from Saccharomyces cerevisiae via homology with CYP102, a unique bacterial cytochrome P450 isoform: quantitative structure-activity relationships (QSARs) within two related series of antifungal azole derivatives.
    Lewis DF; Wiseman A; Tarbit MH
    J Enzyme Inhib; 1999; 14(3):175-92. PubMed ID: 10445042
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A molecular model of CYP2D6 constructed by homology with the CYP2C5 crystallographic template: investigation of enzyme-substrate interactions.
    Lewis DF; Dickins M; Lake BG; Goldfarb PS
    Drug Metabol Drug Interact; 2003; 19(3):189-210. PubMed ID: 14682610
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Homology modelling of human cytochromes P450 involved in xenobiotic metabolism and rationalization of substrate selectivity.
    Lewis DF
    Exp Toxicol Pathol; 1999 Jul; 51(4-5):369-74. PubMed ID: 10445400
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.
    Flanagan JU; Maréchal JD; Ward R; Kemp CA; McLaughlin LA; Sutcliffe MJ; Roberts GC; Paine MJ; Wolf CR
    Biochem J; 2004 Jun; 380(Pt 2):353-60. PubMed ID: 14992686
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.