BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

323 related articles for article (PubMed ID: 9151738)

  • 1. Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.
    Guo Q; Sopher BL; Furukawa K; Pham DG; Robinson N; Martin GM; Mattson MP
    J Neurosci; 1997 Jun; 17(11):4212-22. PubMed ID: 9151738
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis.
    Guo Q; Robinson N; Mattson MP
    J Biol Chem; 1998 May; 273(20):12341-51. PubMed ID: 9575187
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production.
    Keller JN; Guo Q; Holtsberg FW; Bruce-Keller AJ; Mattson MP
    J Neurosci; 1998 Jun; 18(12):4439-50. PubMed ID: 9614221
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide.
    Guo Q; Furukawa K; Sopher BL; Pham DG; Xie J; Robinson N; Martin GM; Mattson MP
    Neuroreport; 1996 Dec; 8(1):379-83. PubMed ID: 9051814
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Presenilin-1 mutation alters NGF-induced neurite outgrowth, calcium homeostasis, and transcription factor (AP-1) activation in PC12 cells.
    Furukawa K; Guo Q; Schellenberg GD; Mattson MP
    J Neurosci Res; 1998 Jun; 52(5):618-24. PubMed ID: 9632318
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function.
    Guo Q; Christakos S; Robinson N; Mattson MP
    Proc Natl Acad Sci U S A; 1998 Mar; 95(6):3227-32. PubMed ID: 9501245
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Superoxide mediates the cell-death-enhancing action of presenilin-1 mutations.
    Guo Q; Fu W; Holtsberg FW; Steiner SM; Mattson MP
    J Neurosci Res; 1999 Jun; 56(5):457-70. PubMed ID: 10369213
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Estrogens stabilize mitochondrial function and protect neural cells against the pro-apoptotic action of mutant presenilin-1.
    Mattson MP; Robinson N; Guo Q
    Neuroreport; 1997 Dec; 8(17):3817-21. PubMed ID: 9427376
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease.
    Mattson MP; Guo Q; Furukawa K; Pedersen WA
    J Neurochem; 1998 Jan; 70(1):1-14. PubMed ID: 9422341
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Cell and molecular neurobiology of presenilins: a role for the endoplasmic reticulum in the pathogenesis of Alzheimer's disease?
    Mattson MP; Guo Q
    J Neurosci Res; 1997 Nov; 50(4):505-13. PubMed ID: 9404712
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12.
    Chan SL; Culmsee C; Haughey N; Klapper W; Mattson MP
    Neurobiol Dis; 2002 Oct; 11(1):2-19. PubMed ID: 12460542
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Depletion of intracellular Ca2+ store itself may be a major factor in thapsigargin-induced ER stress and apoptosis in PC12 cells.
    Yoshida I; Monji A; Tashiro K; Nakamura K; Inoue R; Kanba S
    Neurochem Int; 2006 Jun; 48(8):696-702. PubMed ID: 16481070
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Thapsigargin affects presenilin-2 but not presenilin-1 regulation in SK-N-BE cells.
    Rivabene R; Visentin S; Piscopo P; De Nuccio C; Crestini A; Svetoni F; Rosa P; Confaloni A
    Exp Biol Med (Maywood); 2014 Feb; 239(2):213-24. PubMed ID: 24363250
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Pro-apoptotic effect of presenilin 2 (PS2) overexpression is associated with down-regulation of Bcl-2 in cultured neurons.
    Araki W; Yuasa K; Takeda S; Takeda K; Shirotani K; Takahashi K; Tabira T
    J Neurochem; 2001 Dec; 79(6):1161-8. PubMed ID: 11752057
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Numb modifies neuronal vulnerability to amyloid beta-peptide in an isoform-specific manner by a mechanism involving altered calcium homeostasis: implications for neuronal death in Alzheimer's disease.
    Chan SL; Pedersen WA; Zhu H; Mattson MP
    Neuromolecular Med; 2002; 1(1):55-67. PubMed ID: 12025816
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease.
    Mohmmad Abdul H; Sultana R; Keller JN; St Clair DK; Markesbery WR; Butterfield DA
    J Neurochem; 2006 Mar; 96(5):1322-35. PubMed ID: 16478525
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis.
    Mattson MP; Zhu H; Yu J; Kindy MS
    J Neurosci; 2000 Feb; 20(4):1358-64. PubMed ID: 10662826
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.
    Oulès B; Del Prete D; Greco B; Zhang X; Lauritzen I; Sevalle J; Moreno S; Paterlini-Bréchot P; Trebak M; Checler F; Benfenati F; Chami M
    J Neurosci; 2012 Aug; 32(34):11820-34. PubMed ID: 22915123
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.
    Siman R; Reaume AG; Savage MJ; Trusko S; Lin YG; Scott RW; Flood DG
    J Neurosci; 2000 Dec; 20(23):8717-26. PubMed ID: 11102478
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation.
    Wolozin B; Iwasaki K; Vito P; Ganjei JK; Lacanà E; Sunderland T; Zhao B; Kusiak JW; Wasco W; D'Adamio L
    Science; 1996 Dec; 274(5293):1710-3. PubMed ID: 8939861
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.