295 related articles for article (PubMed ID: 9152363)
1. Studies on the metabolic activation of disulfiram in rat. Evidence for electrophilic S-oxygenated metabolites as inhibitors of aldehyde dehydrogenase and precursors of urinary N-acetylcysteine conjugates.
Hu P; Jin L; Baillie TA
J Pharmacol Exp Ther; 1997 May; 281(2):611-7. PubMed ID: 9152363
[TBL] [Abstract][Full Text] [Related]
2. Characterization of diethyldithiocarbamate methyl ester sulfine as an intermediate in the bioactivation of disulfiram.
Madan A; Faiman MD
J Pharmacol Exp Ther; 1995 Feb; 272(2):775-80. PubMed ID: 7853193
[TBL] [Abstract][Full Text] [Related]
3. Identification of the human P-450 enzymes responsible for the sulfoxidation and thiono-oxidation of diethyldithiocarbamate methyl ester: role of P-450 enzymes in disulfiram bioactivation.
Madan A; Parkinson A; Faiman MD
Alcohol Clin Exp Res; 1998 Sep; 22(6):1212-9. PubMed ID: 9756035
[TBL] [Abstract][Full Text] [Related]
4. In vivo pharmacodynamic studies of the disulfiram metabolite S-methyl N,N-diethylthiolcarbamate sulfoxide: inhibition of liver aldehyde dehydrogenase.
Hart BW; Faiman MD
Alcohol Clin Exp Res; 1994 Apr; 18(2):340-5. PubMed ID: 8048736
[TBL] [Abstract][Full Text] [Related]
5. Identification of novel glutathione conjugates of disulfiram and diethyldithiocarbamate in rat bile by liquid chromatography-tandem mass spectrometry. Evidence for metabolic activation of disulfiram in vivo.
Jin L; Davis MR; Hu P; Baillie TA
Chem Res Toxicol; 1994; 7(4):526-33. PubMed ID: 7981417
[TBL] [Abstract][Full Text] [Related]
6. Diethyldithiocarbamate methyl ester sulfoxide, an inhibitor of rat liver mitochondrial low Km aldehyde dehydrogenase and putative metabolite of disulfiram.
Madan A; Faiman MD
Alcohol Clin Exp Res; 1994 Aug; 18(4):1013-7. PubMed ID: 7978080
[TBL] [Abstract][Full Text] [Related]
7. S-methyl-N,N-diethylthiocarbamate sulfoxide and S-methyl-N,N-diethylthiocarbamate sulfone, two candidates for the active metabolite of disulfiram.
Mays DC; Nelson AN; Lam-Holt J; Fauq AH; Lipsky JJ
Alcohol Clin Exp Res; 1996 May; 20(3):595-600. PubMed ID: 8727261
[TBL] [Abstract][Full Text] [Related]
8. NADPH-dependent, regioselective S-oxidation of a thionosulfur- and thioether-containing xenobiotic, diethyldithiocarbamate methyl ester by rat liver microsomes.
Madan A; Faiman MD
Drug Metab Dispos; 1994; 22(2):324-30. PubMed ID: 8013289
[TBL] [Abstract][Full Text] [Related]
9. Glutathione carbamoylation with S-methyl N,N-diethylthiolcarbamate sulfoxide and sulfone. Mitochondrial low Km aldehyde dehydrogenase inhibition and implications for its alcohol-deterrent action.
Ningaraj NS; Schloss JV; Williams TD; Faiman MD
Biochem Pharmacol; 1998 Mar; 55(6):749-56. PubMed ID: 9586946
[TBL] [Abstract][Full Text] [Related]
10. Fate and distribution of [14C]S-(N,N-diethyldithiocarbamoyl)-N-acetyl-L-cysteine, an antimutagenic mixed disulfide from disulfiram, in rats.
Lee BH; Ryu JC; Park J; Bertram B; Wiessler M
Arzneimittelforschung; 1995 Dec; 45(12):1319-23. PubMed ID: 8595092
[TBL] [Abstract][Full Text] [Related]
11. Bioactivation of S-methyl N,N-diethylthiolcarbamate to S-methyl N,N-diethylthiolcarbamate sulfoxide. Implications for the role of cytochrome P450.
Hart BW; Faiman MD
Biochem Pharmacol; 1993 Dec; 46(12):2285-90. PubMed ID: 8274162
[TBL] [Abstract][Full Text] [Related]
12. Identification of the protein-drug adduct formed between aldehyde dehydrogenase and S-methyl-N,N-diethylthiocarbamoyl sulfoxide by on-line proteolytic digestion high performance liquid chromatography electrospray ionization mass spectrometry.
Shen ML; Johnson KL; Mays DC; Lipsky JJ; Naylor S
Rapid Commun Mass Spectrom; 2000; 14(10):918-23. PubMed ID: 10825257
[TBL] [Abstract][Full Text] [Related]
13. Inhibition of recombinant human mitochondrial and cytosolic aldehyde dehydrogenases by two candidates for the active metabolites of disulfiram.
Lam JP; Mays DC; Lipsky JJ
Biochemistry; 1997 Nov; 36(44):13748-54. PubMed ID: 9354647
[TBL] [Abstract][Full Text] [Related]
14. S-methyl-N,N-diethylthiolcarbamate: a disulfiram metabolite and potent rat liver mitochondrial low Km aldehyde dehydrogenase inhibitor.
Hart BW; Yourick JJ; Faiman MD
Alcohol; 1990; 7(2):165-9. PubMed ID: 2158327
[TBL] [Abstract][Full Text] [Related]
15. The disulfiram metabolites S-methyl-N,N-diethyldithiocarbamoyl sulfoxide and S-methyl-N,N-diethylthiocarbamoyl sulfone irreversibly inactivate betaine aldehyde dehydrogenase from Pseudomonas aeruginosa, both in vitro and in situ, and arrest bacterial growth.
Zaldívar-Machorro VJ; López-Ortiz M; Demare P; Regla I; Muñoz-Clares RA
Biochimie; 2011 Feb; 93(2):286-95. PubMed ID: 20933050
[TBL] [Abstract][Full Text] [Related]
16. Glutathione- and glutathione-S-transferase-dependent oxidative desulfuration of the thione xenobiotic diethyldithiocarbamate methyl ester.
Madan A; Williams TD; Faiman MD
Mol Pharmacol; 1994 Dec; 46(6):1217-25. PubMed ID: 7808445
[TBL] [Abstract][Full Text] [Related]
17. Parenteral N,N-diethyldithiocarbamate produces segmental demyelination in the rat that is not dependent on cysteine carbamylation.
Tonkin EG; Valentine HL; Zimmerman LJ; Valentine WM
Toxicol Appl Pharmacol; 2003 Jun; 189(2):139-50. PubMed ID: 12781632
[TBL] [Abstract][Full Text] [Related]
18. Disulfiram metabolism as a requirement for the inhibition of rat liver mitochondrial low Km aldehyde dehydrogenase.
Yourick JJ; Faiman MD
Biochem Pharmacol; 1991 Sep; 42(7):1361-6. PubMed ID: 1656985
[TBL] [Abstract][Full Text] [Related]
19. N-acetyl-S-(N,N-diethylcarbamoyl) cysteine in rat nucleus accumbens, medial prefrontal cortex, and in rat and human plasma after disulfiram administration.
Winefield RD; Heemskerk AA; Kaul S; Williams TD; Caspers MJ; Prisinzano TE; McCance-Katz EF; Lunte CE; Faiman MD
J Pharm Biomed Anal; 2015 Mar; 107():518-25. PubMed ID: 25720821
[TBL] [Abstract][Full Text] [Related]
20. Identification of the human and rat P450 enzymes responsible for the sulfoxidation of S-methyl N,N-diethylthiolcarbamate (DETC-ME). The terminal step in the bioactivation of disulfiram.
Madan A; Parkinson A; Faiman MD
Drug Metab Dispos; 1995 Oct; 23(10):1153-62. PubMed ID: 8654205
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
