These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

188 related articles for article (PubMed ID: 9154928)

  • 1. Effects of serpin binding on the target proteinase: global stabilization, localized increased structural flexibility, and conserved hydrogen bonding at the active site.
    Kaslik G; Kardos J; Szabó E; Szilágyi L; Závodszky P; Westler WM; Markley JL; Gráf L
    Biochemistry; 1997 May; 36(18):5455-64. PubMed ID: 9154928
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Properties of the His57-Asp102 dyad of rat trypsin D189S in the zymogen, activated enzyme, and alpha1-proteinase inhibitor complexed forms.
    Kaslik G; Westler WM; Gráf L; Markley JL
    Arch Biochem Biophys; 1999 Feb; 362(2):254-64. PubMed ID: 9989934
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The pH dependence of serpin-proteinase complex dissociation reveals a mechanism of complex stabilization involving inactive and active conformational states of the proteinase which are perturbable by calcium.
    Calugaru SV; Swanson R; Olson ST
    J Biol Chem; 2001 Aug; 276(35):32446-55. PubMed ID: 11404362
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A serpin-induced extensive proteolytic susceptibility of urokinase-type plasminogen activator implicates distortion of the proteinase substrate-binding pocket and oxyanion hole in the serpin inhibitory mechanism.
    Egelund R; Petersen TE; Andreasen PA
    Eur J Biochem; 2001 Feb; 268(3):673-85. PubMed ID: 11168406
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Conformational distributions of protease-serpin complexes: a partially translocated complex.
    Liu L; Mushero N; Hedstrom L; Gershenson A
    Biochemistry; 2006 Sep; 45(36):10865-72. PubMed ID: 16953572
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Differential effects of heparin and glucose on structural conformation of human alpha1 antitrypsin: evidence for a heparin-induced cleaved form of the inhibitor.
    Finotti P; de Laureto PP
    Arch Biochem Biophys; 1997 Nov; 347(1):19-29. PubMed ID: 9344460
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Probing the local conformational change of alpha1-antitrypsin.
    Baek JH; Im H; Kang UB; Seong KM; Lee C; Kim J; Yu MH
    Protein Sci; 2007 Sep; 16(9):1842-50. PubMed ID: 17660256
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Trypsin complexed with alpha 1-proteinase inhibitor has an increased structural flexibility.
    Kaslik G; Patthy A; Bálint M; Gráf L
    FEBS Lett; 1995 Aug; 370(3):179-83. PubMed ID: 7656972
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Change in environment of the P1 side chain upon progression from the Michaelis complex to the covalent serpin-proteinase complex.
    Futamura A; Stratikos E; Olson ST; Gettins PG
    Biochemistry; 1998 Sep; 37(38):13110-9. PubMed ID: 9748317
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
    Katz BA; Elrod K; Luong C; Rice MJ; Mackman RL; Sprengeler PA; Spencer J; Hataye J; Janc J; Link J; Litvak J; Rai R; Rice K; Sideris S; Verner E; Young W
    J Mol Biol; 2001 Apr; 307(5):1451-86. PubMed ID: 11292354
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Formation of a noncovalent serpin-proteinase complex involves no conformational change in the serpin. Use of 1H-15N HSQC NMR as a sensitive nonperturbing monitor of conformation.
    Peterson FC; Gordon NC; Gettins PG
    Biochemistry; 2000 Oct; 39(39):11884-92. PubMed ID: 11009600
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Active site distortion is sufficient for proteinase inhibition by serpins: structure of the covalent complex of alpha1-proteinase inhibitor with porcine pancreatic elastase.
    Dementiev A; Dobó J; Gettins PG
    J Biol Chem; 2006 Feb; 281(6):3452-7. PubMed ID: 16321984
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Insight into the mechanism of serpin-proteinase inhibition from 2D [1H-15N] NMR studies of the 69 kDa alpha 1-proteinase inhibitor Pittsburgh-trypsin covalent complex.
    Peterson FC; Gettins PG
    Biochemistry; 2001 May; 40(21):6284-92. PubMed ID: 11371190
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Kinetic intermediates en route to the final serpin-protease complex: studies of complexes of α1-protease inhibitor with trypsin.
    Maddur AA; Swanson R; Izaguirre G; Gettins PG; Olson ST
    J Biol Chem; 2013 Nov; 288(44):32020-35. PubMed ID: 24047901
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 A and full insertion of the reactive center loop into beta-sheet A.
    Stratikos E; Gettins PG
    Proc Natl Acad Sci U S A; 1999 Apr; 96(9):4808-13. PubMed ID: 10220375
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Studies of specificity and catalysis in trypsin by structural analysis of site-directed mutants.
    Sprang SR; Fletterick RJ; Gráf L; Rutter WJ; Craik CS
    Crit Rev Biotechnol; 1988; 8(3):225-36. PubMed ID: 3063392
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The P6-P2 region of serpins is critical for proteinase inhibition and complex stability.
    Chaillan-Huntington CE; Gettins PG; Huntington JA; Patston PA
    Biochemistry; 1997 Aug; 36(31):9562-70. PubMed ID: 9236002
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The structure of a Michaelis serpin-protease complex.
    Ye S; Cech AL; Belmares R; Bergstrom RC; Tong Y; Corey DR; Kanost MR; Goldsmith EJ
    Nat Struct Biol; 2001 Nov; 8(11):979-83. PubMed ID: 11685246
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Role of the catalytic serine in the interactions of serine proteinases with protein inhibitors of the serpin family. Contribution of a covalent interaction to the binding energy of serpin-proteinase complexes.
    Olson ST; Bock PE; Kvassman J; Shore JD; Lawrence DA; Ginsburg D; Björk I
    J Biol Chem; 1995 Dec; 270(50):30007-17. PubMed ID: 8530403
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The contribution of two disulfide bonds in the trypsin binding domain of horsegram (Dolichos biflorus) Bowman-Birk inhibitor to thermal stability and functionality.
    Kumar V; Gowda LR
    Arch Biochem Biophys; 2013 Sep; 537(1):49-61. PubMed ID: 23791628
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.