BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

364 related articles for article (PubMed ID: 9160754)

  • 1. Skeletal and CNS defects in Presenilin-1-deficient mice.
    Shen J; Bronson RT; Chen DF; Xia W; Selkoe DJ; Tonegawa S
    Cell; 1997 May; 89(4):629-39. PubMed ID: 9160754
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression.
    Qian S; Jiang P; Guan XM; Singh G; Trumbauer ME; Yu H; Chen HY; Van de Ploeg LH; Zheng H
    Neuron; 1998 Mar; 20(3):611-7. PubMed ID: 9539133
    [TBL] [Abstract][Full Text] [Related]  

  • 3. An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.
    Davis JA; Naruse S; Chen H; Eckman C; Younkin S; Price DL; Borchelt DR; Sisodia SS; Wong PC
    Neuron; 1998 Mar; 20(3):603-9. PubMed ID: 9539132
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice.
    Wen PH; Hof PR; Chen X; Gluck K; Austin G; Younkin SG; Younkin LH; DeGasperi R; Gama Sosa MA; Robakis NK; Haroutunian V; Elder GA
    Exp Neurol; 2004 Aug; 188(2):224-37. PubMed ID: 15246822
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
    Mastrangelo P; Mathews PM; Chishti MA; Schmidt SD; Gu Y; Yang J; Mazzella MJ; Coomaraswamy J; Horne P; Strome B; Pelly H; Levesque G; Ebeling C; Jiang Y; Nixon RA; Rozmahel R; Fraser PE; St George-Hyslop P; Carlson GA; Westaway D
    Proc Natl Acad Sci U S A; 2005 Jun; 102(25):8972-7. PubMed ID: 15951428
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis.
    Mattson MP; Zhu H; Yu J; Kindy MS
    J Neurosci; 2000 Feb; 20(4):1358-64. PubMed ID: 10662826
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease.
    Mathews PM; Cataldo AM; Kao BH; Rudnicki AG; Qin X; Yang JL; Jiang Y; Picciano M; Hulette C; Lippa CF; Bird TD; Nochlin D; Walter J; Haass C; Lévesque L; Fraser PE; Andreadis A; Nixon RA
    Mol Med; 2000 Oct; 6(10):878-91. PubMed ID: 11126202
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain.
    Lee J; Chan SL; Mattson MP
    Neuromolecular Med; 2002; 2(1):29-45. PubMed ID: 12230303
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Presenilin-1-deficient neurons are nitric oxide-dependently killed by hydrogen peroxide in vitro.
    Nakajima M; Shirasawa T
    Neuroscience; 2004; 125(3):563-8. PubMed ID: 15099670
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Presenilin 1 is essential for cardiac morphogenesis.
    Nakajima M; Moriizumi E; Koseki H; Shirasawa T
    Dev Dyn; 2004 Aug; 230(4):795-9. PubMed ID: 15254914
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm.
    Wong PC; Zheng H; Chen H; Becher MW; Sirinathsinghji DJ; Trumbauer ME; Chen HY; Price DL; Van der Ploeg LH; Sisodia SS
    Nature; 1997 May; 387(6630):288-92. PubMed ID: 9153393
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
    Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ
    Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Altered morphological and electrophysiological properties of Cajal-Retzius cells in cerebral cortex of embryonic Presenilin-1 knockout mice.
    Kilb W; Hartmann D; Saftig P; Luhmann HJ
    Eur J Neurosci; 2004 Nov; 20(10):2749-56. PubMed ID: 15548218
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mice lacking both presenilin genes exhibit early embryonic patterning defects.
    Donoviel DB; Hadjantonakis AK; Ikeda M; Zheng H; Hyslop PS; Bernstein A
    Genes Dev; 1999 Nov; 13(21):2801-10. PubMed ID: 10557208
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Impaired proteolytic processing of presenilin-1 in chromosome 14-linked familial Alzheimer's disease patient lymphocytes.
    Takahashi H; Mercken M; Honda T; Saito Y; Murayama M; Song S; Takashima A
    Neurosci Lett; 1999 Jan; 260(2):121-4. PubMed ID: 10025714
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Presenilin-1 regulates neuronal differentiation during neurogenesis.
    Handler M; Yang X; Shen J
    Development; 2000 Jun; 127(12):2593-606. PubMed ID: 10821758
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Processing of wild-type and mutant familial Alzheimer's disease-associated presenilin-1 in cultured neurons.
    Weihl CC; Ghadge GD; Miller RJ; Roos RP
    J Neurochem; 1999 Jul; 73(1):31-40. PubMed ID: 10386952
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Abnormal blood vessel development in mice lacking presenilin-1.
    Nakajima M; Yuasa S; Ueno M; Takakura N; Koseki H; Shirasawa T
    Mech Dev; 2003 Jun; 120(6):657-67. PubMed ID: 12834865
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Neural progenitor cells do not differentiate prematurely in presenilin-1 null mutant mice.
    Wen PH; De Gasperi R; Gama Sosa MA; Elder GA
    Neurosci Lett; 2004 Nov; 371(2-3):249-54. PubMed ID: 15519767
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically.
    Grilli M; Diodato E; Lozza G; Brusa R; Casarini M; Uberti D; Rozmahel R; Westaway D; St George-Hyslop P; Memo M; Ongini E
    Proc Natl Acad Sci U S A; 2000 Nov; 97(23):12822-7. PubMed ID: 11070093
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.