276 related articles for article (PubMed ID: 9163336)
1. Endoplasmic reticulum Ca2+ is important for the proteolytic processing and intracellular transport of proinsulin in the pancreatic beta-cell.
Guest PC; Bailyes EM; Hutton JC
Biochem J; 1997 Apr; 323 ( Pt 2)(Pt 2):445-50. PubMed ID: 9163336
[TBL] [Abstract][Full Text] [Related]
2. Long-term elevation of free fatty acids leads to delayed processing of proinsulin and prohormone convertases 2 and 3 in the pancreatic beta-cell line MIN6.
Furukawa H; Carroll RJ; Swift HH; Steiner DF
Diabetes; 1999 Jul; 48(7):1395-401. PubMed ID: 10389844
[TBL] [Abstract][Full Text] [Related]
3. Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3.
Zhu X; Orci L; Carroll R; Norrbom C; Ravazzola M; Steiner DF
Proc Natl Acad Sci U S A; 2002 Aug; 99(16):10299-304. PubMed ID: 12136131
[TBL] [Abstract][Full Text] [Related]
4. Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2.
Benjannet S; Rondeau N; Paquet L; Boudreault A; Lazure C; Chrétien M; Seidah NG
Biochem J; 1993 Sep; 294 ( Pt 3)(Pt 3):735-43. PubMed ID: 8397508
[TBL] [Abstract][Full Text] [Related]
5. Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells.
Malide D; Seidah NG; Chrétien M; Bendayan M
J Histochem Cytochem; 1995 Jan; 43(1):11-9. PubMed ID: 7822759
[TBL] [Abstract][Full Text] [Related]
6. Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic beta-cell.
Goodge KA; Hutton JC
Semin Cell Dev Biol; 2000 Aug; 11(4):235-42. PubMed ID: 10966857
[TBL] [Abstract][Full Text] [Related]
7. Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.
Alarcón C; Leahy JL; Schuppin GT; Rhodes CJ
J Clin Invest; 1995 Mar; 95(3):1032-9. PubMed ID: 7883951
[TBL] [Abstract][Full Text] [Related]
8. Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2.
Furuta M; Carroll R; Martin S; Swift HH; Ravazzola M; Orci L; Steiner DF
J Biol Chem; 1998 Feb; 273(6):3431-7. PubMed ID: 9452465
[TBL] [Abstract][Full Text] [Related]
9. Immunocytochemical investigation of insulin secretion by pancreatic beta-cells in control and diabetic Psammomys obesus.
Bendayan M; Malide D; Ziv E; Levy E; Ben-Sasson R; Kalman R; Bar-On H; Chrétien M; Seidah N
J Histochem Cytochem; 1995 Aug; 43(8):771-84. PubMed ID: 7622840
[TBL] [Abstract][Full Text] [Related]
10. Proinsulin processing in the diabetic Goto-Kakizaki rat.
Guest PC; Abdel-Halim SM; Gross DJ; Clark A; Poitout V; Amaria R; Ostenson CG; Hutton JC
J Endocrinol; 2002 Dec; 175(3):637-47. PubMed ID: 12475375
[TBL] [Abstract][Full Text] [Related]
11. Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin-producing MIN6 cell line.
Skelly RH; Schuppin GT; Ishihara H; Oka Y; Rhodes CJ
Diabetes; 1996 Jan; 45(1):37-43. PubMed ID: 8522057
[TBL] [Abstract][Full Text] [Related]
12. Processing of synthetic pro-islet amyloid polypeptide (proIAPP) 'amylin' by recombinant prohormone convertase enzymes, PC2 and PC3, in vitro.
Higham CE; Hull RL; Lawrie L; Shennan KI; Morris JF; Birch NP; Docherty K; Clark A
Eur J Biochem; 2000 Aug; 267(16):4998-5004. PubMed ID: 10931181
[TBL] [Abstract][Full Text] [Related]
13. Differences in pH optima and calcium requirements for maturation of the prohormone convertases PC2 and PC3 indicates different intracellular locations for these events.
Shennan KI; Taylor NA; Jermany JL; Matthews G; Docherty K
J Biol Chem; 1995 Jan; 270(3):1402-7. PubMed ID: 7836407
[TBL] [Abstract][Full Text] [Related]
14. Chromogranin A processing and secretion: specific role of endogenous and exogenous prohormone convertases in the regulated secretory pathway.
Eskeland NL; Zhou A; Dinh TQ; Wu H; Parmer RJ; Mains RE; O'Connor DT
J Clin Invest; 1996 Jul; 98(1):148-56. PubMed ID: 8690787
[TBL] [Abstract][Full Text] [Related]
15. Prohormone convertases (PC1/3 and PC2) in rat and human pancreas and islet cell tumors: subcellular immunohistochemical analysis.
Itoh Y; Tanaka S; Takekoshi S; Itoh J; Osamura RY
Pathol Int; 1996 Oct; 46(10):726-37. PubMed ID: 8916141
[TBL] [Abstract][Full Text] [Related]
16. Levels of the conversion endoproteases PC1 (PC3) and PC2 distinguish between insulin-producing pancreatic islet beta cells and non-beta cells.
Neerman-Arbez M; Cirulli V; Halban PA
Biochem J; 1994 May; 300 ( Pt 1)(Pt 1):57-61. PubMed ID: 8198551
[TBL] [Abstract][Full Text] [Related]
17. The post-translational processing and intracellular sorting of carboxypeptidase H in the islets of Langerhans.
Guest PC; Arden SD; Rutherford NG; Hutton JC
Mol Cell Endocrinol; 1995 Aug; 113(1):99-108. PubMed ID: 8674818
[TBL] [Abstract][Full Text] [Related]
18. Ionic milieu controls the compartment-specific activation of pro-opiomelanocortin processing in AtT-20 cells.
Schmidt WK; Moore HP
Mol Biol Cell; 1995 Oct; 6(10):1271-85. PubMed ID: 8573786
[TBL] [Abstract][Full Text] [Related]
19. Functioning human insulinomas. An immunohistochemical analysis of intracellular insulin processing.
Azzoni C; D'Adda T; Tamburrano G; Coscelli C; Madsen OD; Scopsi L; Bordi C
Virchows Arch; 1998 Dec; 433(6):495-504. PubMed ID: 9870681
[TBL] [Abstract][Full Text] [Related]
20. The post-translational processing of chromogranin A in the pancreatic islet: involvement of the eukaryote subtilisin PC2.
Arden SD; Rutherford NG; Guest PC; Curry WJ; Bailyes EM; Johnston CF; Hutton JC
Biochem J; 1994 Mar; 298 Pt 3(Pt 3):521-8. PubMed ID: 8141763
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]