These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

256 related articles for article (PubMed ID: 9168257)

  • 1. Hydrogen peroxide supports human and rat cytochrome P450 1A2-catalyzed 2-amino-3-methylimidazo[4,5-f]quinoline bioactivation to mutagenic metabolites: significance of cytochrome P450 peroxygenase.
    Anari MR; Josephy PD; Henry T; O'Brien PJ
    Chem Res Toxicol; 1997 May; 10(5):582-8. PubMed ID: 9168257
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Cytochrome P450 dependent xenobiotic activation by physiological hydroperoxides in intact hepatocytes.
    Anari MR; Khan S; Jatoe SD; O'Brien PJ
    Eur J Drug Metab Pharmacokinet; 1997; 22(4):305-10. PubMed ID: 9512925
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cytochromes P450 in cynomolgus monkeys mutagenically activate 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) but not 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).
    Sadrieh N; Snyderwine EG
    Carcinogenesis; 1995 Jul; 16(7):1549-55. PubMed ID: 7614688
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The inhibition by flavonoids of 2-amino-3-methylimidazo[4,5-f]quinoline metabolic activation to a mutagen: a structure-activity relationship study.
    Edenharder R; Rauscher R; Platt KL
    Mutat Res; 1997 Sep; 379(1):21-32. PubMed ID: 9330619
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Prenylflavonoids from hops inhibit the metabolic activation of the carcinogenic heterocyclic amine 2-amino-3-methylimidazo[4, 5-f]quinoline, mediated by cDNA-expressed human CYP1A2.
    Miranda CL; Yang YH; Henderson MC; Stevens JF; Santana-Rios G; Deinzer ML; Buhler DR
    Drug Metab Dispos; 2000 Nov; 28(11):1297-302. PubMed ID: 11038156
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Modulation of the mutagenic effects of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) in bacteria with rat-liver 9000 x g supernatant or monolayers of rat hepatocytes as an activation system.
    Holme JA; Brunborg G; Alexander J; Trygg B; Bjørnstad C
    Mutat Res; 1988 Jan; 197(1):39-49. PubMed ID: 3275882
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Use of genetically engineered Salmonella typhimurium OY1002/1A2 strain coexpressing human cytochrome P450 1A2 and NADPH-cytochrome P450 reductase and bacterial O-acetyltransferase in SOS/umu assay.
    Aryal P; Terashita T; Guengerich FP; Shimada T; Oda Y
    Environ Mol Mutagen; 2000; 36(2):121-6. PubMed ID: 11013410
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Activation of 6-aminochrysene to genotoxic products by different forms of rat liver cytochrome P450 in an O-acetyltransferase-overexpressing Salmonella typhimurium strain (NM2009).
    Yamazaki H; Shimada T
    Biochem Pharmacol; 1992 Sep; 44(5):913-20. PubMed ID: 1530660
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Evaluation of Escherichia coli DJ4309 expressing human P450 1A2 in mutagenicity testing of complex food mixtures.
    Constable A; Varga N; Josephy PD; Guy P; Turesky RJ
    Mutat Res; 1999 Jun; 442(2):79-87. PubMed ID: 10393276
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Roles of different forms of cytochrome P450 in the activation of the promutagen 6-aminochrysene to genotoxic metabolites in human liver microsomes.
    Yamazaki H; Mimura M; Oda Y; Inui Y; Shiraga T; Iwasaki K; Guengerich FP; Shimada T
    Carcinogenesis; 1993 Jul; 14(7):1271-8. PubMed ID: 8330339
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Nitrogen-substitution effects on the mutagenicity and cytochrome P450 isoform-selectivity of chrysene analogs.
    Yamada K; Hakura A; Kato TA; Mizutani T; Saeki K
    Mutat Res; 2005 Sep; 586(1):87-95. PubMed ID: 16087391
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Microsomal activation of 2-amino-3-methylimidazo[4,5-f]quinoline, a pyrolysate of sardine and beef extracts, to a mutagenic intermediate.
    Yamazoe Y; Shimada M; Kamataki T; Kato R
    Cancer Res; 1983 Dec; 43(12 Pt 1):5768-74. PubMed ID: 6416669
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Cytochrome P450 forms in the rodent lung involved in the metabolic activation of food-derived heterocyclic amines.
    Hellmold H; Overvik E; Strömstedt M; Gustafsson JA
    Carcinogenesis; 1993 Sep; 14(9):1751-7. PubMed ID: 8403195
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Contribution of CYP1A1 and CYP1A2 to the activation of heterocyclic amines in monkeys and human.
    Edwards RJ; Murray BP; Murray S; Schulz T; Neubert D; Gant TW; Thorgeirsson SS; Boobis AR; Davies DS
    Carcinogenesis; 1994 May; 15(5):829-36. PubMed ID: 8200083
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Activation of heterocyclic aromatic amines by rat and human liver microsomes and by purified rat and human cytochrome P450 1A2.
    Turesky RJ; Constable A; Richoz J; Varga N; Markovic J; Martin MV; Guengerich FP
    Chem Res Toxicol; 1998 Aug; 11(8):925-36. PubMed ID: 9705755
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification of new 2-amino-3-methylimidazo[4,5-f]quinoline urinary metabolites from beta-naphthoflavone-treated mice.
    Lakshmi VM; Hsu FF; Zenser TV
    Drug Metab Dispos; 2009 Aug; 37(8):1690-7. PubMed ID: 19451400
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mutagenic activation of IQ, PhIP and MeIQx by hepatic microsomes from rat, monkey and man: low mutagenic activation of MeIQx in cynomolgus monkeys in vitro reflects low DNA adduct levels in vivo.
    Davis CD; Schut HA; Adamson RH; Thorgeirsson UP; Thorgeirsson SS; Snyderwine EG
    Carcinogenesis; 1993 Jan; 14(1):61-5. PubMed ID: 8425272
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Activation and effects of the food-derived heterocyclic amines in extrahepatic tissues.
    Overvik E; Hellmold H; Branting C; Gustafsson JA
    Princess Takamatsu Symp; 1995; 23():123-33. PubMed ID: 8844803
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Selection of human cytochrome P450 1A2 mutants with enhanced catalytic activity for heterocyclic amine N-hydroxylation.
    Kim D; Guengerich FP
    Biochemistry; 2004 Feb; 43(4):981-8. PubMed ID: 14744142
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Regioselective differences in C(8)- and N-oxidation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by human and rat liver microsomes and cytochromes P450 1A2.
    Turesky RJ; Parisod V; Huynh-Ba T; Langouët S; Guengerich FP
    Chem Res Toxicol; 2001 Jul; 14(7):901-11. PubMed ID: 11453738
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.