BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

1430 related articles for article (PubMed ID: 9171884)

  • 1. Biological and conformational examination of stereochemical modifications using the template melanotropin peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp-Ala-Lys]-NH2, on human melanocortin receptors.
    Haskell-Luevano C; Nikiforovich G; Sharma SD; Yang YK; Dickinson C; Hruby VJ; Gantz I
    J Med Chem; 1997 May; 40(11):1738-48. PubMed ID: 9171884
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Three-dimensional molecular models of the hMC1R melanocortin receptor: complexes with melanotropin peptide agonists.
    Haskell-Luevano C; Sawyer TK; Trumpp-Kallmeyer S; Bikker JA; Humblet C; Gantz I; Hruby VJ
    Drug Des Discov; 1996 Dec; 14(3):197-211. PubMed ID: 9017363
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-activity relationships of gamma-MSH analogues at the human melanocortin MC3, MC4, and MC5 receptors. Discovery of highly selective hMC3R, hMC4R, and hMC5R analogues.
    Balse-Srinivasan P; Grieco P; Cai M; Trivedi D; Hruby VJ
    J Med Chem; 2003 Nov; 46(23):4965-73. PubMed ID: 14584947
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of prototype peptidomimetic agonists at the human melanocortin receptors MC1R and MC4R.
    Haskell-Luevano C; Hendrata S; North C; Sawyer TK; Hadley ME; Hruby VJ; Dickinson C; Gantz I
    J Med Chem; 1997 Jul; 40(14):2133-9. PubMed ID: 9216831
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Potent and selective agonists of alpha-melanotropin (alphaMSH) action at human melanocortin receptor 5; linear analogs of alpha-melanotropin.
    Bednarek MA; MacNeil T; Tang R; Fong TM; Cabello MA; Maroto M; Teran A
    Peptides; 2007 May; 28(5):1020-8. PubMed ID: 17376561
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure-activity relationships of novel cyclic alpha-MSH/beta-MSH hybrid analogues that lead to potent and selective ligands for the human MC3R and human MC5R.
    Balse-Srinivasan P; Grieco P; Cai M; Trivedi D; Hruby VJ
    J Med Chem; 2003 Aug; 46(17):3728-33. PubMed ID: 12904077
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design and synthesis of highly potent and selective melanotropin analogues of SHU9119 modified at position 6.
    Grieco P; Han G; Weinberg D; Van der Ploeg LH; Hruby VJ
    Biochem Biophys Res Commun; 2002 Apr; 292(4):1075-80. PubMed ID: 11944925
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors.
    Hruby VJ; Lu D; Sharma SD; Castrucci AL; Kesterson RA; al-Obeidi FA; Hadley ME; Cone RD
    J Med Chem; 1995 Sep; 38(18):3454-61. PubMed ID: 7658432
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Characterizations of the unusual dissociation properties of melanotropin peptides from the melanocortin receptor, hMC1R.
    Haskell-Luevano C; Miwa H; Dickinson C; Hadley ME; Hruby VJ; Yamada T; Gantz I
    J Med Chem; 1996 Jan; 39(2):432-5. PubMed ID: 8558511
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Potent and selective agonists of human melanocortin receptor 5: cyclic analogues of alpha-melanocyte-stimulating hormone.
    Bednarek MA; MacNeil T; Tang R; Fong TM; Cabello MA; Maroto M; Teran A
    J Med Chem; 2007 May; 50(10):2520-6. PubMed ID: 17455928
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands.
    Wilczynski A; Wang XS; Joseph CG; Xiang Z; Bauzo RM; Scott JW; Sorensen NB; Shaw AM; Millard WJ; Richards NG; Haskell-Luevano C
    J Med Chem; 2004 Apr; 47(9):2194-207. PubMed ID: 15084118
    [TBL] [Abstract][Full Text] [Related]  

  • 12. De novo design, synthesis, and pharmacology of alpha-melanocyte stimulating hormone analogues derived from somatostatin by a hybrid approach.
    Han G; Haskell-Luevano C; Kendall L; Bonner G; Hadley ME; Cone RD; Hruby VJ
    J Med Chem; 2004 Mar; 47(6):1514-26. PubMed ID: 14998337
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Accelerating sensory recovery after sciatic nerve crush: non-selective versus melanocortin MC4 receptor-selective peptides.
    Nijenhuis WA; Wanders N; Kruijtzer JA; Liskamp RM; Gispen WH; Adan RA
    Eur J Pharmacol; 2004 Jul; 495(2-3):145-52. PubMed ID: 15249163
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structure-activity relationships of the unique and potent agouti-related protein (AGRP)-melanocortin chimeric Tyr-c[beta-Asp-His-DPhe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2 peptide template.
    Wilczynski A; Wilson KR; Scott JW; Edison AS; Haskell-Luevano C
    J Med Chem; 2005 Apr; 48(8):3060-75. PubMed ID: 15828845
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Chimeric NDP-MSH and MTII melanocortin peptides with agouti-related protein (AGRP) Arg-Phe-Phe amino acids possess agonist melanocortin receptor activity.
    Joseph CG; Wilczynski A; Holder JR; Xiang Z; Bauzo RM; Scott JW; Haskell-Luevano C
    Peptides; 2003 Dec; 24(12):1899-908. PubMed ID: 15127941
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamics.
    Al-Obeidi F; Castrucci AM; Hadley ME; Hruby VJ
    J Med Chem; 1989 Dec; 32(12):2555-61. PubMed ID: 2555512
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Analogs of alpha-melanocyte stimulating hormone with high agonist potency and selectivity at human melanocortin receptor 1b: the role of Trp(9) in molecular recognition.
    Bednarek MA; Macneil T; Tang R; Fong TM; Angeles Cabello M; Maroto M; Teran A
    Biopolymers; 2008 May; 89(5):401-8. PubMed ID: 17926329
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cysteine residues are involved in structure and function of melanocortin 1 receptor: Substitution of a cysteine residue in transmembrane segment two converts an agonist to antagonist.
    Frändberg PA; Doufexis M; Kapas S; Chhajlani V
    Biochem Biophys Res Commun; 2001 Mar; 281(4):851-7. PubMed ID: 11237737
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Peptide and small molecules rescue the functional activity and agonist potency of dysfunctional human melanocortin-4 receptor polymorphisms.
    Xiang Z; Pogozheva ID; Sorenson NB; Wilczynski AM; Holder JR; Litherland SA; Millard WJ; Mosberg HI; Haskell-Luevano C
    Biochemistry; 2007 Jul; 46(28):8273-87. PubMed ID: 17590021
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Biological and conformational study of beta-substituted prolines in MT-II template: steric effects leading to human MC5 receptor selectivity.
    Cai M; Cai C; Mayorov AV; Xiong C; Cabello CM; Soloshonok VA; Swift JR; Trivedi D; Hruby VJ
    J Pept Res; 2004 Feb; 63(2):116-31. PubMed ID: 15009533
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 72.