BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

204 related articles for article (PubMed ID: 9174411)

  • 1. Selective peptidic and peptidomimetic inhibitors of Candida albicans myristoylCoA: protein N-myristoyltransferase: a new approach to antifungal therapy.
    Sikorski JA; Devadas B; Zupec ME; Freeman SK; Brown DL; Lu HF; Nagarajan S; Mehta PP; Wade AC; Kishore NS; Bryant ML; Getman DP; McWherter CA; Gordon JI
    Biopolymers; 1997; 43(1):43-71. PubMed ID: 9174411
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity.
    Devadas B; Freeman SK; Zupec ME; Lu HF; Nagarajan SR; Kishore NS; Lodge JK; Kuneman DW; McWherter CA; Vinjamoori DV; Getman DP; Gordon JI; Sikorski JA
    J Med Chem; 1997 Aug; 40(16):2609-25. PubMed ID: 9258368
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Scanning alanine mutagenesis and de-peptidization of a Candida albicans myristoyl-CoA:protein N-myristoyltransferase octapeptide substrate reveals three elements critical for molecular recognition.
    McWherter CA; Rocque WJ; Zupec ME; Freeman SK; Brown DL; Devadas B; Getman DP; Sikorski JA; Gordon JI
    J Biol Chem; 1997 May; 272(18):11874-80. PubMed ID: 9115247
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Conformationally constrained [p-(omega-aminoalkyl)phenacetyl]-L-seryl-L-lysyl dipeptide amides as potent peptidomimetic inhibitors of Candida albicans and human myristoyl-CoA:protein N-myristoyl transferase.
    Nagarajan SR; Devadas B; Zupec ME; Freeman SK; Brown DL; Lu HF; Mehta PP; Kishore NS; McWherter CA; Getman DP; Gordon JI; Sikorski JA
    J Med Chem; 1997 May; 40(10):1422-38. PubMed ID: 9154965
    [TBL] [Abstract][Full Text] [Related]  

  • 5. N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase.
    Lodge JK; Jackson-Machelski E; Devadas B; Zupec ME; Getman DP; Kishore N; Freeman SK; McWherter CA; Sikorski JA; Gordon JI
    Microbiology (Reading); 1997 Feb; 143 ( Pt 2)():357-366. PubMed ID: 9043113
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Novel biologically active nonpeptidic inhibitors of myristoylCoA:protein N-myristoyltransferase.
    Devadas B; Freeman SK; McWherter CA; Kishore NS; Lodge JK; Jackson-Machelski E; Gordon JI; Sikorski JA
    J Med Chem; 1998 Mar; 41(6):996-1000. PubMed ID: 9526574
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Cyclohexyl-octahydro-pyrrolo[1,2-a]pyrazine-based inhibitors of human N-myristoyltransferase-1.
    French KJ; Zhuang Y; Schrecengost RS; Copper JE; Xia Z; Smith CD
    J Pharmacol Exp Ther; 2004 Apr; 309(1):340-7. PubMed ID: 14724220
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, synthesis and antifungal activity of isosteric analogues of benzoheterocyclic N-myristoyltransferase inhibitors.
    Sheng C; Xu H; Wang W; Cao Y; Dong G; Wang S; Che X; Ji H; Miao Z; Yao J; Zhang W
    Eur J Med Chem; 2010 Sep; 45(9):3531-40. PubMed ID: 20615585
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Molecular cloning and biochemical characterization of bovine spleen myristoyl CoA:protein N-myristoyltransferase.
    Raju RV; Anderson JW; Datla RS; Sharma RK
    Arch Biochem Biophys; 1997 Dec; 348(1):134-42. PubMed ID: 9390183
    [TBL] [Abstract][Full Text] [Related]  

  • 10. N-terminal N-myristoylation of proteins: refinement of the sequence motif and its taxon-specific differences.
    Maurer-Stroh S; Eisenhaber B; Eisenhaber F
    J Mol Biol; 2002 Apr; 317(4):523-40. PubMed ID: 11955007
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Titration calorimetric analysis of AcylCoA recognition by myristoylCoA:protein N-myristoyltransferase.
    Bhatnagar RS; Schall OF; Jackson-Machelski E; Sikorski JA; Devadas B; Gokel GW; Gordon JI
    Biochemistry; 1997 Jun; 36(22):6700-8. PubMed ID: 9184150
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis of potent and selective inhibitors of Candida albicans N-myristoyltransferase based on the benzothiazole structure.
    Yamazaki K; Kaneko Y; Suwa K; Ebara S; Nakazawa K; Yasuno K
    Bioorg Med Chem; 2005 Apr; 13(7):2509-22. PubMed ID: 15755653
    [TBL] [Abstract][Full Text] [Related]  

  • 13. FTR1335 is a novel synthetic inhibitor of Candida albicans N-myristoyltransferase with fungicidal activity.
    Ebara S; Naito H; Nakazawa K; Ishii F; Nakamura M
    Biol Pharm Bull; 2005 Apr; 28(4):591-5. PubMed ID: 15802792
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Genetic studies reveal that myristoylCoA:protein N-myristoyltransferase is an essential enzyme in Candida albicans.
    Weinberg RA; McWherter CA; Freeman SK; Wood DC; Gordon JI; Lee SC
    Mol Microbiol; 1995 Apr; 16(2):241-50. PubMed ID: 7565086
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Genetic and biochemical studies establish that the fungicidal effect of a fully depeptidized inhibitor of Cryptococcus neoformans myristoyl-CoA:protein N-myristoyltransferase (Nmt) is Nmt-dependent.
    Lodge JK; Jackson-Machelski E; Higgins M; McWherter CA; Sikorski JA; Devadas B; Gordon JI
    J Biol Chem; 1998 May; 273(20):12482-91. PubMed ID: 9575206
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A feature based pharmacophore for Candida albicans MyristoylCoA: protein N-myristoyltransferase inhibitors.
    Karki RG; Kulkarni VM
    Eur J Med Chem; 2001 Feb; 36(2):147-63. PubMed ID: 11311746
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structure of N-myristoyltransferase with bound myristoylCoA and peptide substrate analogs.
    Bhatnagar RS; Fütterer K; Farazi TA; Korolev S; Murray CL; Jackson-Machelski E; Gokel GW; Gordon JI; Waksman G
    Nat Struct Biol; 1998 Dec; 5(12):1091-7. PubMed ID: 9846880
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Potent inhibitor of N-myristoylation: a novel molecular target for cancer.
    Shrivastav A; Pasha MK; Selvakumar P; Gowda S; Olson DJ; Ross AR; Dimmock JR; Sharma RK
    Cancer Res; 2003 Nov; 63(22):7975-8. PubMed ID: 14633729
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Effects of L-histidine and its structural analogues on human N-myristoyltransferase activity and importance of EEVEH amino acid sequence for enzyme activity.
    Raju RV; Datla RS; Warrington RC; Sharma RK
    Biochemistry; 1998 Oct; 37(42):14928-36. PubMed ID: 9778369
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors.
    Sogabe S; Masubuchi M; Sakata K; Fukami TA; Morikami K; Shiratori Y; Ebiike H; Kawasaki K; Aoki Y; Shimma N; D'Arcy A; Winkler FK; Banner DW; Ohtsuka T
    Chem Biol; 2002 Oct; 9(10):1119-28. PubMed ID: 12401496
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.