BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

316 related articles for article (PubMed ID: 9188478)

  • 1. Toward antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1 and novel in vivo stable prodrugs of methotrexate.
    Smith GK; Banks S; Blumenkopf TA; Cory M; Humphreys J; Laethem RM; Miller J; Moxham CP; Mullin R; Ray PH; Walton LM; Wolfe LA
    J Biol Chem; 1997 Jun; 272(25):15804-16. PubMed ID: 9188478
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1: in vitro and in vivo studies with prodrugs of methotrexate and the thymidylate synthase inhibitors GW1031 and GW1843.
    Wolfe LA; Mullin RJ; Laethem R; Blumenkopf TA; Cory M; Miller JF; Keith BR; Humphreys J; Smith GK
    Bioconjug Chem; 1999; 10(1):38-48. PubMed ID: 9893962
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2.
    Laethem RM; Blumenkopf TA; Cory M; Elwell L; Moxham CP; Ray PH; Walton LM; Smith GK
    Arch Biochem Biophys; 1996 Aug; 332(1):8-18. PubMed ID: 8806703
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Activation of methotrexate-phenylalanine by monoclonal antibody--carboxypeptidase A conjugate for the specific treatment of ovarian cancer in vitro.
    Perron MJ; Page M
    Br J Cancer; 1996 Feb; 73(3):281-7. PubMed ID: 8562331
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Methotrexate-alpha-phenylalanine: optimization of methotrexate prodrug for activation by carboxypeptidase A-monoclonal antibody conjugate.
    Vitols KS; Haag-Zeino B; Baer T; Montejano YD; Huennekens FM
    Cancer Res; 1995 Feb; 55(3):478-81. PubMed ID: 7834611
    [TBL] [Abstract][Full Text] [Related]  

  • 6. In vitro and in vivo prodrug therapy of prostate cancer using anti-gamma-Sm-scFv/hCPA fusion protein.
    Hao XK; Liu JY; Yue QH; Wu GJ; Bai YJ; Yin Y
    Prostate; 2006 Jun; 66(8):858-66. PubMed ID: 16491483
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Specific tumour localisation of a huA33 antibody--carboxypeptidase A conjugate and activation of methotrexate-phenylalanine.
    Deckert PM; Bornmann WG; Ritter G; Williams C; Franke J; Keilholz U; Thiel E; Old LJ; Bertino JR; Welt S
    Int J Oncol; 2004 May; 24(5):1289-95. PubMed ID: 15067353
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Activation of methotrexate-alpha-alanine by carboxypeptidase A-monoclonal antibody conjugate.
    Haenseler E; Esswein A; Vitols KS; Montejano Y; Mueller BM; Reisfeld RA; Huennekens FM
    Biochemistry; 1992 Jan; 31(3):891-7. PubMed ID: 1731945
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Expression of endogenously activated secreted or cell surface carboxypeptidase A sensitizes tumor cells to methotrexate-alpha-peptide prodrugs.
    Hamstra DA; Pagé M; Maybaum J; Rehemtulla A
    Cancer Res; 2000 Feb; 60(3):657-65. PubMed ID: 10676650
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Development of methotrexate alpha-peptides as prodrugs for activation by enzyme-monoclonal antibody conjugates.
    Huennekens FM
    Adv Enzyme Regul; 1997; 37():77-92. PubMed ID: 9381987
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Construction and chemotherapeutic potential of carboxypeptidase-A/monoclonal antibody conjugate.
    Esswein A; Hänseler E; Montejano Y; Vitols KS; Huennekens FM
    Adv Enzyme Regul; 1991; 31():3-12. PubMed ID: 1877392
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Toward an enzyme/prodrug strategy for cancer gene therapy: endogenous activation of carboxypeptidase A mutants by the PACE/Furin family of propeptidases.
    Hamstra DA; Rehemtulla A
    Hum Gene Ther; 1999 Jan; 10(2):235-48. PubMed ID: 10022548
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Carboxypeptidase-mediated release of methotrexate from methotrexate alpha-peptides.
    Kuefner U; Lohrmann U; Montejano YD; Vitols KS; Huennekens FM
    Biochemistry; 1989 Mar; 28(5):2288-97. PubMed ID: 2719954
    [TBL] [Abstract][Full Text] [Related]  

  • 14. [The solid-phase synthesis of methotrexate-alpha-peptides].
    Shi PT; Hao XK; Chen Y; Zhang YH; Tao QY
    Yao Xue Xue Bao; 1997; 32(2):106-9. PubMed ID: 11243192
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Novel integrin-targeted binding-triggered drug delivery system for methotrexate.
    Kotamraj P; Russu WA; Jasti B; Wu J; Li X
    Pharm Res; 2011 Dec; 28(12):3208-19. PubMed ID: 21695561
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The methotrexate story: a paradigm for development of cancer chemotherapeutic agents.
    Huennekens FM
    Adv Enzyme Regul; 1994; 34():397-419. PubMed ID: 7942284
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Production of "biobetter" glucarpidase variants to improve drug detoxification and antibody directed enzyme prodrug therapy for cancer treatment.
    AlQahtani AD; Al-Mansoori L; Bashraheel SS; Rashidi FB; Al-Yafei A; Elsinga P; Domling A; Goda SK
    Eur J Pharm Sci; 2019 Jan; 127():79-91. PubMed ID: 30343151
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Antibody-enzyme conjugates for cancer therapy.
    Melton RG; Sherwood RF
    J Natl Cancer Inst; 1996 Feb; 88(3-4):153-65. PubMed ID: 8632489
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Methotrexate-based amphiphilic prodrug nanoaggregates for co-administration of multiple therapeutics and synergistic cancer therapy.
    Hou M; Gao YE; Shi X; Bai S; Ma X; Li B; Xiao B; Xue P; Kang Y; Xu Z
    Acta Biomater; 2018 Sep; 77():228-239. PubMed ID: 30006314
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Enhancement of antibody-directed enzyme prodrug therapy in colorectal xenografts by an antivascular agent.
    Pedley RB; Sharma SK; Boxer GM; Boden R; Stribbling SM; Davies L; Springer CJ; Begent RH
    Cancer Res; 1999 Aug; 59(16):3998-4003. PubMed ID: 10463598
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.