BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

108 related articles for article (PubMed ID: 9193869)

  • 1. Stereoselective metabolism of rac-mexiletine by the fungus Cunninghamella echinulata yields the major human metabolites hydroxymethylmexiletine and p-hydroxymexiletine.
    Freitag DG; Foster RT; Coutts RT; Pickard MA; Pasutto FM
    Drug Metab Dispos; 1997 Jun; 25(6):685-92. PubMed ID: 9193869
    [TBL] [Abstract][Full Text] [Related]  

  • 2. High-performance liquid chromatographic method for resolving the enantiomers of mexiletine and two major metabolites isolated from microbial fermentation media.
    Freitag DG; Foster RT; Coutts RT; Pasutto FM
    J Chromatogr; 1993 Jul; 616(2):253-9. PubMed ID: 8376507
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Enantioselective determination of mexiletine and its metabolites p-hydroxymexiletine and hydroxymethylmexiletine in rat plasma by normal-phase liquid chromatography-tandem mass spectrometry: application to pharmacokinetics.
    Godoy AL; Parisi CC; Marques MP; Coelho EB; Lanchote VL
    Chirality; 2009 Jul; 21(7):648-56. PubMed ID: 18973279
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mexiletine metabolism in vitro by human liver.
    Broly F; Libersa C; Lhermitte M
    Drug Metab Dispos; 1990; 18(3):362-8. PubMed ID: 1974200
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Enantioselective determination of the hydroxylated metabolites of mexiletine in human plasma.
    Lanchote VL; Bonato PS; Cesarino EJ; Mere Júnior YA; Cavani SR; Santos J; Bertucci C
    Chirality; 1997; 9(8):732-8. PubMed ID: 9435098
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Pharmacokinetics of mexiletine and its metabolites, hydroxymethylmexiletine and p-hydroxymexiletine, after single oral administration in healthy subjects.
    Paczkowski D; Sadowski Z; Filipek M; Koliński P
    Pol J Pharmacol Pharm; 1990; 42(4):365-75. PubMed ID: 2097598
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The metabolism of mexiletine in relation to the debrisoquine/sparteine-type polymorphism of drug oxidation.
    Broly F; Vandamme N; Libersa C; Lhermitte M
    Br J Clin Pharmacol; 1991 Oct; 32(4):459-66. PubMed ID: 1958440
    [TBL] [Abstract][Full Text] [Related]  

  • 8. High-performance liquid chromatographic assay for mexiletine hydroxylation in microsomes of human liver.
    Broly F; Libersa C; Lhermitte M
    J Chromatogr; 1988 Oct; 431(2):369-78. PubMed ID: 3243791
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Direct analysis of the enantiomers of mexiletine and its metabolites in plasma and urine using an HPLC-CSP.
    Fieger H; Wainer IW
    J Pharm Biomed Anal; 1993; 11(11-12):1173-9. PubMed ID: 8123732
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Influence of the CYP2D6*10 allele on the metabolism of mexiletine by human liver microsomes.
    Senda C; Yamaura Y; Kobayashi K; Fujii H; Minami H; Sasaki Y; Igarashi T; Chiba K
    Br J Clin Pharmacol; 2001 Jul; 52(1):100-3. PubMed ID: 11453897
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Enantioselective analysis of N-hydroxymexiletine glucuronide in human plasma for pharmacokinetic studies.
    Lanchote VL; Santos VJ; Cesarino EJ; Dreossi SA; Mere Júnior Y; Santos SR
    Chirality; 1999; 11(2):85-90. PubMed ID: 9951400
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels.
    Catalano A; Desaphy JF; Lentini G; Carocci A; Di Mola A; Bruno C; Carbonara R; De Palma A; Budriesi R; Ghelardini C; Perrone MG; Colabufo NA; Conte Camerino D; Franchini C
    J Med Chem; 2012 Feb; 55(3):1418-22. PubMed ID: 22191686
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents.
    De Bellis M; De Luca A; Rana F; Cavalluzzi MM; Catalano A; Lentini G; Franchini C; Tortorella V; Conte Camerino D
    Br J Pharmacol; 2006 Oct; 149(3):300-10. PubMed ID: 16921388
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Stereoselective serum protein binding of mexiletine enantiomers in man.
    McErlane KM; Igwemezie L; Kerr CR
    Res Commun Chem Pathol Pharmacol; 1987 Apr; 56(1):141-4. PubMed ID: 3589151
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Effect of cigarette smoking on mexiletine kinetics.
    Grech-Bélanger O; Gilbert M; Turgeon J; LeBlanc PP
    Clin Pharmacol Ther; 1985 Jun; 37(6):638-43. PubMed ID: 4006363
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Searching for new antiarrhythmic agents: evaluation of meta-hydroxymexiletine enantiomers.
    Catalano A; Budriesi R; Bruno C; Di Mola A; Defrenza I; Cavalluzzi MM; Micucci M; Carocci A; Franchini C; Lentini G
    Eur J Med Chem; 2013 Jul; 65():511-6. PubMed ID: 23777871
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Meta-hydroxymexiletine, a new metabolite of mexiletine. Isolation, characterization, and species differences in its formation.
    Grech-Bélanger O; Turgeon J; Lalande M; Bélanger PM
    Drug Metab Dispos; 1991; 19(2):458-61. PubMed ID: 1676654
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Stereoselective metabolism of mexiletine in Chagasic women with ventricular arrhythmias.
    Lanchote VL; Cesarino EJ; Santos VJ; Moraes Júnior AV; Zanardi AM; Santos SR
    Eur J Drug Metab Pharmacokinet; 1998; 23(2):259-66. PubMed ID: 9725491
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of human liver cytochrome P-450 1A2 by the class IB antiarrhythmics mexiletine, lidocaine, and tocainide.
    Wei X; Dai R; Zhai S; Thummel KE; Friedman FK; Vestal RE
    J Pharmacol Exp Ther; 1999 May; 289(2):853-8. PubMed ID: 10215663
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Stereospecific synthesis of "para-hydroxymexiletine" and sodium channel blocking activity evaluation.
    Catalano A; Carocci A; Fracchiolla G; Franchini C; Lentini G; Tortorella V; De Luca A; De Bellis M; Desaphy JF; Conte Camerino D
    Chirality; 2004 Feb; 16(2):72-8. PubMed ID: 14712469
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.