191 related articles for article (PubMed ID: 9210198)
1. Role of brain tissue localized purine metabolizing enzymes in the central nervous system delivery of anti-HIV agents 2'-beta-fluoro-2',3'-dideoxyinosine and 2'-beta-fluoro-2',3'-dideoxyadenosine in rats.
Singhal D; Morgan ME; Anderson BD
Pharm Res; 1997 Jun; 14(6):786-92. PubMed ID: 9210198
[TBL] [Abstract][Full Text] [Related]
2. Role of altered metabolism in dideoxynucleoside pharmacokinetics. Studies of 2'-beta-fluoro-2',3'-dideoxyinosine and 2'-beta-fluoro-2',3'-dideoxyadenosine in rats.
Singhal D; Morgan ME; Anderson BD
Drug Metab Dispos; 1996 Oct; 24(10):1155-61. PubMed ID: 8894519
[TBL] [Abstract][Full Text] [Related]
3. Absorption and intestinal metabolism of purine dideoxynucleosides and an adenosine deaminase-activated prodrug of 2',3'-dideoxyinosine in the mesenteric vein cannulated rat ileum.
Singhal D; Ho NF; Anderson BD
J Pharm Sci; 1998 May; 87(5):569-77. PubMed ID: 9572907
[TBL] [Abstract][Full Text] [Related]
4. Enhanced oral bioavailability of 2'- beta-fluoro-2',3'-dideoxyadenosine (F-ddA) through local inhibition of intestinal adenosine deaminase.
DeGraw RT; Anderson BD
Pharm Res; 2001 Sep; 18(9):1270-6. PubMed ID: 11683239
[TBL] [Abstract][Full Text] [Related]
5. Investigation of the mechanism of enhancement of central nervous system delivery of 2'-beta-fluoro-2',3'-dideoxyinosine via a blood-brain barrier adenosine deaminase-activated prodrug.
Johnson MD; Chen J; Anderson BD
Drug Metab Dispos; 2002 Feb; 30(2):191-8. PubMed ID: 11792690
[TBL] [Abstract][Full Text] [Related]
6. Localization of purine metabolizing enzymes in bovine brain microvessel endothelial cells: an enzymatic blood-brain barrier for dideoxynucleosides?
Johnson MD; Anderson BD
Pharm Res; 1996 Dec; 13(12):1881-6. PubMed ID: 8987089
[TBL] [Abstract][Full Text] [Related]
7. 2'-beta-fluoro-2',3'-dideoxyadenosine, lodenosine, in rhesus monkeys: plasma and cerebrospinal fluid pharmacokinetics and urinary disposition.
Roth JS; McCully CM; Balis FM; Poplack DG; Kelley JA
Drug Metab Dispos; 1999 Oct; 27(10):1128-32. PubMed ID: 10497138
[TBL] [Abstract][Full Text] [Related]
8. Determination of carrier-mediated transport of 2',3'-dideoxypurine nucleosides in the rat ileum using a bidirectional perfusion technique.
DeGraw RT; Anderson BD
Pharm Res; 2004 Feb; 21(2):300-8. PubMed ID: 15032312
[TBL] [Abstract][Full Text] [Related]
9. Lipophilic, acid-stable, adenosine deaminase-activated anti-HIV prodrugs for central nervous system delivery. 2. 6-Halo and 6-alkoxy prodrugs of 2'-beta-fluoro-2',3'-dideoxyinosine.
Ford H; Siddiqui MA; Driscoll JS; Marquez VE; Kelley JA; Mitsuya H; Shirasaka T
J Med Chem; 1995 Mar; 38(7):1189-95. PubMed ID: 7707321
[TBL] [Abstract][Full Text] [Related]
10. Enhancement by 2'-deoxycoformycin of the 5'-phosphorylation and anti-human immunodeficiency virus activity of 2',3'-dideoxyadenosine and 2'-beta-fluoro-2',3'-dideoxyadenosine.
Ahluwalia GS; Cooney DA; Shirasaka T; Mitsuya H; Driscoll JS; Johns DG
Mol Pharmacol; 1994 Nov; 46(5):1002-8. PubMed ID: 7969062
[TBL] [Abstract][Full Text] [Related]
11. In vitro and in vivo evaluation of 6-azido-2',3'-dideoxy-2'-fluoro-beta-D-arabinofuranosylpurine and N6-methyl-2',3'-dideoxy-2'-fluoro-beta-D-arabinofuranosyladenine as prodrugs of the anti-HIV nucleosides 2'-F-ara-ddA and 2'-F-ara-ddI.
Koudriakova T; Manouilov KK; Shanmuganathan K; Kotra LP; Boudinot FD; Cretton-Scott E; Sommadossi JP; Schinazi RF; Chu CK
J Med Chem; 1996 Nov; 39(23):4676-81. PubMed ID: 8917656
[TBL] [Abstract][Full Text] [Related]
12. Disposition of 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine in mice.
el Dareer SM; Tillery KF; Kalin JR; Hill DL
Invest New Drugs; 1989 Jul; 7(2-3):139-46. PubMed ID: 2507472
[TBL] [Abstract][Full Text] [Related]
13. Lipophilic, acid-stable, adenosine deaminase-activated anti-HIV prodrugs for central nervous system delivery. 3. 6-Amino prodrugs of 2'-beta-fluoro-2',3'-dideoxyinosine.
Driscoll JS; Siddiqui MA; Ford H; Kelley JA; Roth JS; Mitsuya H; Tanaka M; Marquez VE
J Med Chem; 1996 Apr; 39(8):1619-25. PubMed ID: 8648601
[TBL] [Abstract][Full Text] [Related]
14. Enhanced oral bioavailability of DDI after administration of 6-Cl-ddP, an adenosine deaminase-activated prodrug, to chronically catheterized rats.
Anderson BD; Morgan ME; Singhal D
Pharm Res; 1995 Aug; 12(8):1126-33. PubMed ID: 7494823
[TBL] [Abstract][Full Text] [Related]
15. Use of cultured cerebral capillary endothelial cells in modeling the central nervous system availability of 2',3'-dideoxyinosine.
Johnson MD; Anderson BD
J Pharm Sci; 2000 Mar; 89(3):322-35. PubMed ID: 10707013
[TBL] [Abstract][Full Text] [Related]
16. Acute cardiotoxicity of the Anti-HIV dideoxynucleoside, F-ddA, in the rat.
Donzanti BA; Kelley JA; Tomaszewski JE; Roth JS; Tosca P; Placke M; Singer A; Yarrington JT; Driscoll JS
Fundam Appl Toxicol; 1995 Sep; 27(2):167-76. PubMed ID: 8529811
[TBL] [Abstract][Full Text] [Related]
17. Single dose and multiple dose pharmacokinetics of 2'-fluoro-2',3'-dideoxyadenosine and 2'-fluoro-2',3'-dideoxyinosine, anti-HIV agents, in rats.
Srinivas NR; Shyu WC
Eur J Drug Metab Pharmacokinet; 1999; 24(4):329-34. PubMed ID: 10892896
[TBL] [Abstract][Full Text] [Related]
18. Metabolism in human leukocytes of anti-HIV dideoxypurine nucleosides.
Fridland A; Johnson MA; Cooney DA; Ahluwalia G; Marquez VE; Driscoll JS; Johns DG
Ann N Y Acad Sci; 1990; 616():205-16. PubMed ID: 2078020
[TBL] [Abstract][Full Text] [Related]
19. cycloSal-Pronucleotides of 2'-fluoro-ara- and 2'-fluoro-ribo-2',3'- dideoxyadenosine as a strategy to bypass a metabolic blockade.
Meier C; Knispel T; Marquez VE; Siddiqui MA; De Clercq E; Balzarini J
J Med Chem; 1999 May; 42(9):1615-24. PubMed ID: 10229630
[TBL] [Abstract][Full Text] [Related]
20. Central nervous system targeting of 2',3'-dideoxyinosine via adenosine deaminase-activated 6-halo-dideoxypurine prodrugs.
Morgan ME; Chi SC; Murakami K; Mitsuya H; Anderson BD
Antimicrob Agents Chemother; 1992 Oct; 36(10):2156-65. PubMed ID: 1444295
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
