451 related articles for article (PubMed ID: 9220969)
1. Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis.
He YA; He YQ; Szklarz GD; Halpert JR
Biochemistry; 1997 Jul; 36(29):8831-9. PubMed ID: 9220969
[TBL] [Abstract][Full Text] [Related]
2. Analysis of four residues within substrate recognition site 4 of human cytochrome P450 3A4: role in steroid hydroxylase activity and alpha-naphthoflavone stimulation.
Domanski TL; Liu J; Harlow GR; Halpert JR
Arch Biochem Biophys; 1998 Feb; 350(2):223-32. PubMed ID: 9473295
[TBL] [Abstract][Full Text] [Related]
3. Importance of amino acid residue 474 for substrate specificity of canine and human cytochrome p450 3A enzymes.
He YQ; Roussel F; Halpert JR
Arch Biochem Biophys; 2001 May; 389(2):264-70. PubMed ID: 11339816
[TBL] [Abstract][Full Text] [Related]
4. Dual role of human cytochrome P450 3A4 residue Phe-304 in substrate specificity and cooperativity.
Domanski TL; He YA; Harlow GR; Halpert JR
J Pharmacol Exp Ther; 2000 May; 293(2):585-91. PubMed ID: 10773032
[TBL] [Abstract][Full Text] [Related]
5. Hydrophobic side chain requirements for lauric acid and progesterone hydroxylation at amino acid 113 in cytochrome P450 2C2, a potential determinant of substrate specificity.
Straub P; Johnson EF; Kemper B
Arch Biochem Biophys; 1993 Nov; 306(2):521-7. PubMed ID: 8215458
[TBL] [Abstract][Full Text] [Related]
6. Alanine-scanning mutagenesis of a putative substrate recognition site in human cytochrome P450 3A4. Role of residues 210 and 211 in flavonoid activation and substrate specificity.
Harlow GR; Halpert JR
J Biol Chem; 1997 Feb; 272(9):5396-402. PubMed ID: 9038138
[TBL] [Abstract][Full Text] [Related]
7. The importance of SRS-1 residues in catalytic specificity of human cytochrome P450 3A4.
Roussel F; Khan KK; Halpert JR
Arch Biochem Biophys; 2000 Feb; 374(2):269-78. PubMed ID: 10666307
[TBL] [Abstract][Full Text] [Related]
8. Site-directed mutagenesis of the putative distal helix of peroxygenase cytochrome P450.
Matsunaga I; Ueda A; Sumimoto T; Ichihara K; Ayata M; Ogura H
Arch Biochem Biophys; 2001 Oct; 394(1):45-53. PubMed ID: 11566026
[TBL] [Abstract][Full Text] [Related]
9. Role of residues 363 and 206 in conversion of cytochrome P450 2B1 from a steroid 16-hydroxylase to a 15 alpha-hydroxylase.
Luo Z; He YA; Halpert JR
Arch Biochem Biophys; 1994 Feb; 309(1):52-7. PubMed ID: 8117113
[TBL] [Abstract][Full Text] [Related]
10. Structural determinants of progesterone hydroxylation by cytochrome P450 2B5: the role of nonsubstrate recognition site residues.
He YQ; Harlow GR; Szklarz GD; Halpert JR
Arch Biochem Biophys; 1998 Feb; 350(2):333-9. PubMed ID: 9473309
[TBL] [Abstract][Full Text] [Related]
11. Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues.
He YQ; Szklarz GD; Halpert JR
Arch Biochem Biophys; 1996 Nov; 335(1):152-60. PubMed ID: 8914846
[TBL] [Abstract][Full Text] [Related]
12. Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme.
Gillam EM; Baba T; Kim BR; Ohmori S; Guengerich FP
Arch Biochem Biophys; 1993 Aug; 305(1):123-31. PubMed ID: 8342945
[TBL] [Abstract][Full Text] [Related]
13. Site-directed mutagenesis of putative substrate recognition sites in cytochrome P450 2B11: importance of amino acid residues 114, 290, and 363 for substrate specificity.
Hasler JA; Harlow GR; Szklarz GD; John GH; Kedzie KM; Burnett VL; He YA; Kaminsky LS; Halpert JR
Mol Pharmacol; 1994 Aug; 46(2):338-45. PubMed ID: 8078495
[TBL] [Abstract][Full Text] [Related]
14. Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes.
Yamazaki H; Shaw PM; Guengerich FP; Shimada T
Chem Res Toxicol; 1998 Jun; 11(6):659-65. PubMed ID: 9625734
[TBL] [Abstract][Full Text] [Related]
15. Cooperativity in oxidations catalyzed by cytochrome P450 3A4.
Ueng YF; Kuwabara T; Chun YJ; Guengerich FP
Biochemistry; 1997 Jan; 36(2):370-81. PubMed ID: 9003190
[TBL] [Abstract][Full Text] [Related]
16. Application of 3-dimensional homology modeling of cytochrome P450 2B1 for interpretation of site-directed mutagenesis results.
Szklarz GD; Ornstein RL; Halpert JR
J Biomol Struct Dyn; 1994 Aug; 12(1):061-78. PubMed ID: 7848559
[TBL] [Abstract][Full Text] [Related]
17. Characterization of the progesterone 21-hydroxylase activity of canine cytochrome P450 PBD-2/P450 2B11 through reconstitution, heterologous expression, and site-directed mutagenesis.
Born SL; John GH; Harlow GR; Halpert JR
Drug Metab Dispos; 1995 Jul; 23(7):702-7. PubMed ID: 7587957
[TBL] [Abstract][Full Text] [Related]
18. Nonsubstrate recognition site residues are involved in testosterone hydroxylation by cytochrome P450 CYP 2C11.
Biagini CP; Philpot RM; Célier CM
Arch Biochem Biophys; 1999 Jan; 361(2):309-14. PubMed ID: 9882461
[TBL] [Abstract][Full Text] [Related]
19. A conserved proline-rich sequence between the N-terminal signal-anchor and catalytic domains is required for assembly of functional cytochrome P450 2C2.
Chen CD; Doray B; Kemper B
Arch Biochem Biophys; 1998 Feb; 350(2):233-8. PubMed ID: 9473296
[TBL] [Abstract][Full Text] [Related]
20. Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity.
Domanski TL; He YA; Khan KK; Roussel F; Wang Q; Halpert JR
Biochemistry; 2001 Aug; 40(34):10150-60. PubMed ID: 11513592
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
