These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

139 related articles for article (PubMed ID: 9228039)

  • 1. Conformational stabilities of Escherichia coli RNase HI variants with a series of amino acid substitutions at a cavity within the hydrophobic core.
    Akasako A; Haruki M; Oobatake M; Kanaya S
    J Biol Chem; 1997 Jul; 272(30):18686-93. PubMed ID: 9228039
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Stabilization of Escherichia coli ribonuclease HI by cavity-filling mutations within a hydrophobic core.
    Ishikawa K; Nakamura H; Morikawa K; Kanaya S
    Biochemistry; 1993 Jun; 32(24):6171-8. PubMed ID: 8390295
    [TBL] [Abstract][Full Text] [Related]  

  • 3. High resistance of Escherichia coli ribonuclease HI variant with quintuple thermostabilizing mutations to thermal denaturation, acid denaturation, and proteolytic degradation.
    Akasako A; Haruki M; Oobatake M; Kanaya S
    Biochemistry; 1995 Jun; 34(25):8115-22. PubMed ID: 7794925
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Effect of cavity-modulating mutations on the stability of Escherichia coli ribonuclease HI.
    Kimura S; Oda Y; Nakai T; Katayanagi K; Kitakuni E; Nakai C; Nakamura H; Ikehara M; Kanaya S
    Eur J Biochem; 1992 Jun; 206(2):337-43. PubMed ID: 1317795
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Investigating the role of conserved residue Asp134 in Escherichia coli ribonuclease HI by site-directed random mutagenesis.
    Haruki M; Noguchi E; Nakai C; Liu YY; Oobatake M; Itaya M; Kanaya S
    Eur J Biochem; 1994 Mar; 220(2):623-31. PubMed ID: 8125123
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Protein core adaptability: crystal structures of the cavity-filling variants of Escherichia coli RNase HI.
    Tanaka M; Chon H; Angkawidjaja C; Koga Y; Takano K; Kanaya S
    Protein Pept Lett; 2010 Sep; 17(9):1163-9. PubMed ID: 20423323
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Spectroscopic Signature of the Steric Strains in an
    Ota C; Suzuki H; Tanaka SI; Takano K
    J Phys Chem B; 2020 Jan; 124(1):91-100. PubMed ID: 31820984
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Stabilization of Escherichia coli ribonuclease HI by strategic replacement of amino acid residues with those from the thermophilic counterpart.
    Kimura S; Nakamura H; Hashimoto T; Oobatake M; Kanaya S
    J Biol Chem; 1992 Oct; 267(30):21535-42. PubMed ID: 1328237
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structural, thermodynamic, and mutational analyses of a psychrotrophic RNase HI.
    Tadokoro T; You DJ; Abe Y; Chon H; Matsumura H; Koga Y; Takano K; Kanaya S
    Biochemistry; 2007 Jun; 46(25):7460-8. PubMed ID: 17536836
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Stabilization of ribonuclease HI from Thermus thermophilus HB8 by the spontaneous formation of an intramolecular disulfide bond.
    Hirano N; Haruki M; Morikawa M; Kanaya S
    Biochemistry; 1998 Sep; 37(36):12640-8. PubMed ID: 9730837
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of single Mn(2+) binding sites required for activation of the mutant proteins of E.coli RNase HI at Glu48 and/or Asp134 by X-ray crystallography.
    Tsunaka Y; Takano K; Matsumura H; Yamagata Y; Kanaya S
    J Mol Biol; 2005 Feb; 345(5):1171-83. PubMed ID: 15644213
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structural and thermodynamic analyses of Escherichia coli RNase HI variant with quintuple thermostabilizing mutations.
    Haruki M; Tanaka M; Motegi T; Tadokoro T; Koga Y; Takano K; Kanaya S
    FEBS J; 2007 Nov; 274(22):5815-25. PubMed ID: 17944939
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Stabilization of E. coli Ribonuclease HI by the 'stability profile of mutant protein' (SPMP)-inspired random and non-random mutagenesis.
    Haruki M; Saito Y; Ota M; Nishikawa K; Kanaya S
    J Biotechnol; 2006 Jul; 124(3):512-22. PubMed ID: 16545882
    [TBL] [Abstract][Full Text] [Related]  

  • 14. pH-dependent thermostabilization of Escherichia coli ribonuclease HI by histidine to alanine substitutions.
    Kanaya S; Oobatake M; Nakamura H; Ikehara M
    J Biotechnol; 1993 Mar; 28(1):117-36. PubMed ID: 7764048
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Remarkable stabilization of a psychrotrophic RNase HI by a combination of thermostabilizing mutations identified by the suppressor mutation method.
    Tadokoro T; Matsushita K; Abe Y; Rohman MS; Koga Y; Takano K; Kanaya S
    Biochemistry; 2008 Aug; 47(31):8040-7. PubMed ID: 18616283
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Expression, purification, and characterization of a recombinant ribonuclease H from Thermus thermophilus HB8.
    Kanaya S; Itaya M
    J Biol Chem; 1992 May; 267(14):10184-92. PubMed ID: 1315754
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Strong nucleic acid binding to the Escherichia coli RNase HI mutant with two arginine residues at the active site.
    Tsunaka Y; Haruki M; Morikawa M; Kanaya S
    Biochim Biophys Acta; 2001 May; 1547(1):135-42. PubMed ID: 11343799
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Protein thermostabilization requires a fine-tuned placement of surface-charged residues.
    You DJ; Fukuchi S; Nishikawa K; Koga Y; Takano K; Kanaya S
    J Biochem; 2007 Oct; 142(4):507-16. PubMed ID: 17761696
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The N-terminal hybrid binding domain of RNase HI from Thermotoga maritima is important for substrate binding and Mg2+-dependent activity.
    Jongruja N; You DJ; Kanaya E; Koga Y; Takano K; Kanaya S
    FEBS J; 2010 Nov; 277(21):4474-89. PubMed ID: 20875084
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Heat labile ribonuclease HI from a psychrotrophic bacterium: gene cloning, characterization and site-directed mutagenesis.
    Ohtani N; Haruki M; Morikawa M; Kanaya S
    Protein Eng; 2001 Dec; 14(12):975-82. PubMed ID: 11809928
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.