BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

129 related articles for article (PubMed ID: 9249047)

  • 1. 1.8-A crystal structure of the catalytic domain of human neutrophil collagenase (matrix metalloproteinase-8) complexed with a peptidomimetic hydroxamate primed-side inhibitor with a distinct selectivity profile.
    Betz M; Huxley P; Davies SJ; Mushtaq Y; Pieper M; Tschesche H; Bode W; Gomis-RĂ¼th FX
    Eur J Biochem; 1997 Jul; 247(1):356-63. PubMed ID: 9249047
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure determination and analysis of human neutrophil collagenase complexed with a hydroxamate inhibitor.
    Grams F; Crimmin M; Hinnes L; Huxley P; Pieper M; Tschesche H; Bode W
    Biochemistry; 1995 Oct; 34(43):14012-20. PubMed ID: 7577999
    [TBL] [Abstract][Full Text] [Related]  

  • 3. X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design.
    Grams F; Reinemer P; Powers JC; Kleine T; Pieper M; Tschesche H; Huber R; Bode W
    Eur J Biochem; 1995 Mar; 228(3):830-41. PubMed ID: 7737183
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity.
    Bode W; Reinemer P; Huber R; Kleine T; Schnierer S; Tschesche H
    EMBO J; 1994 Mar; 13(6):1263-9. PubMed ID: 8137810
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The design, synthesis, and structure-activity relationships of a series of macrocyclic MMP inhibitors.
    Steinman DH; Curtin ML; Garland RB; Davidsen SK; Heyman HR; Holms JH; Albert DH; Magoc TJ; Nagy IB; Marcotte PA; Li J; Morgan DW; Hutchins C; Summers JB
    Bioorg Med Chem Lett; 1998 Aug; 8(16):2087-92. PubMed ID: 9873491
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors.
    Lovejoy B; Welch AR; Carr S; Luong C; Broka C; Hendricks RT; Campbell JA; Walker KA; Martin R; Van Wart H; Browner MF
    Nat Struct Biol; 1999 Mar; 6(3):217-21. PubMed ID: 10074939
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition.
    Brandstetter H; Grams F; Glitz D; Lang A; Huber R; Bode W; Krell HW; Engh RA
    J Biol Chem; 2001 May; 276(20):17405-12. PubMed ID: 11278347
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure of human neutrophil collagenase reveals large S1' specificity pocket.
    Stams T; Spurlino JC; Smith DL; Wahl RC; Ho TF; Qoronfleh MW; Banks TM; Rubin B
    Nat Struct Biol; 1994 Feb; 1(2):119-23. PubMed ID: 7656015
    [TBL] [Abstract][Full Text] [Related]  

  • 9. High-resolution solution structure of the catalytic fragment of human collagenase-3 (MMP-13) complexed with a hydroxamic acid inhibitor.
    Moy FJ; Chanda PK; Chen JM; Cosmi S; Edris W; Levin JI; Powers R
    J Mol Biol; 2000 Sep; 302(3):671-89. PubMed ID: 10986126
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure.
    Lang R; Kocourek A; Braun M; Tschesche H; Huber R; Bode W; Maskos K
    J Mol Biol; 2001 Sep; 312(4):731-42. PubMed ID: 11575928
    [TBL] [Abstract][Full Text] [Related]  

  • 11. NMR solution structure of the catalytic fragment of human fibroblast collagenase complexed with a sulfonamide derivative of a hydroxamic acid compound.
    Moy FJ; Chanda PK; Chen JM; Cosmi S; Edris W; Skotnicki JS; Wilhelm J; Powers R
    Biochemistry; 1999 Jun; 38(22):7085-96. PubMed ID: 10353819
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket.
    Yamamoto M; Tsujishita H; Hori N; Ohishi Y; Inoue S; Ikeda S; Okada Y
    J Med Chem; 1998 Apr; 41(8):1209-17. PubMed ID: 9548812
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design.
    Gavuzzo E; Pochetti G; Mazza F; Gallina C; Gorini B; D'Alessio S; Pieper M; Tschesche H; Tucker PA
    J Med Chem; 2000 Sep; 43(18):3377-85. PubMed ID: 10978185
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structure of human ADAM-8 catalytic domain complexed with batimastat.
    Hall T; Shieh HS; Day JE; Caspers N; Chrencik JE; Williams JM; Pegg LE; Pauley AM; Moon AF; Krahn JM; Fischer DH; Kiefer JR; Tomasselli AG; Zack MD
    Acta Crystallogr Sect F Struct Biol Cryst Commun; 2012 Jun; 68(Pt 6):616-21. PubMed ID: 22684055
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Computational study of the catalytic domain of human neutrophil collagenase. specific role of the S3 and S'3 subsites in the interaction with a phosphonate inhibitor.
    Aschi M; Roccatano D; Di Nola A; Gallina C; Gavuzzo E; Pochetti G; Pieper M; Tschesche H; Mazza F
    J Comput Aided Mol Des; 2002 Mar; 16(3):213-25. PubMed ID: 12363219
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Crystal structures of recombinant 19-kDa human fibroblast collagenase complexed to itself.
    Lovejoy B; Hassell AM; Luther MA; Weigl D; Jordan SR
    Biochemistry; 1994 Jul; 33(27):8207-17. PubMed ID: 8031754
    [TBL] [Abstract][Full Text] [Related]  

  • 17. N-Hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: mode of binding in a complex with MMP-8.
    Campestre C; Agamennone M; Tortorella P; Preziuso S; Biasone A; Gavuzzo E; Pochetti G; Mazza F; Hiller O; Tschesche H; Consalvi V; Gallina C
    Bioorg Med Chem Lett; 2006 Jan; 16(1):20-4. PubMed ID: 16242329
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structural basis for the highly selective inhibition of MMP-13.
    Engel CK; Pirard B; Schimanski S; Kirsch R; Habermann J; Klingler O; Schlotte V; Weithmann KU; Wendt KU
    Chem Biol; 2005 Feb; 12(2):181-9. PubMed ID: 15734645
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Extra binding region induced by non-zinc chelating inhibitors into the S1' subsite of matrix metalloproteinase 8 (MMP-8).
    Pochetti G; Montanari R; Gege C; Chevrier C; Taveras AG; Mazza F
    J Med Chem; 2009 Feb; 52(4):1040-9. PubMed ID: 19173605
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor.
    Lovejoy B; Cleasby A; Hassell AM; Longley K; Luther MA; Weigl D; McGeehan G; McElroy AB; Drewry D; Lambert MH
    Science; 1994 Jan; 263(5145):375-7. PubMed ID: 8278810
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.