BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

743 related articles for article (PubMed ID: 9278421)

  • 1. Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes.
    Salceda S; Caro J
    J Biol Chem; 1997 Sep; 272(36):22642-7. PubMed ID: 9278421
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway.
    Kallio PJ; Wilson WJ; O'Brien S; Makino Y; Poellinger L
    J Biol Chem; 1999 Mar; 274(10):6519-25. PubMed ID: 10037745
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor alpha (HIF-alpha) proteins.
    Srinivas V; Zhang LP; Zhu XH; Caro J
    Biochem Biophys Res Commun; 1999 Jul; 260(2):557-61. PubMed ID: 10403805
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway.
    Huang LE; Gu J; Schau M; Bunn HF
    Proc Natl Acad Sci U S A; 1998 Jul; 95(14):7987-92. PubMed ID: 9653127
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7.
    Cho S; Choi YJ; Kim JM; Jeong ST; Kim JH; Kim SH; Ryu SE
    FEBS Lett; 2001 Jun; 498(1):62-6. PubMed ID: 11389899
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein.
    Tanimoto K; Makino Y; Pereira T; Poellinger L
    EMBO J; 2000 Aug; 19(16):4298-309. PubMed ID: 10944113
    [TBL] [Abstract][Full Text] [Related]  

  • 7. HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1alpha degradation.
    Berra E; Richard DE; Gothié E; Pouysségur J
    FEBS Lett; 2001 Feb; 491(1-2):85-90. PubMed ID: 11226425
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cadmium blocks hypoxia-inducible factor (HIF)-1-mediated response to hypoxia by stimulating the proteasome-dependent degradation of HIF-1alpha.
    Chun YS; Choi E; Kim GT; Choi H; Kim CH; Lee MJ; Kim MS; Park JW
    Eur J Biochem; 2000 Jul; 267(13):4198-204. PubMed ID: 10866824
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Activation of hypoxia-induced transcription in normoxia.
    Hägg M; Wennström S
    Exp Cell Res; 2005 May; 306(1):180-91. PubMed ID: 15878343
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Co-transactivation of the 3' erythropoietin hypoxia inducible enhancer by the HIF-1 protein.
    Varma S; Cohen HJ
    Blood Cells Mol Dis; 1997 Aug; 23(2):169-76. PubMed ID: 9236155
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Hypoxia-inducible factor 1alpha (HIF-1alpha) is a non-heme iron protein. Implications for oxygen sensing.
    Srinivas V; Zhu X; Salceda S; Nakamura R; Caro J
    J Biol Chem; 1998 Jul; 273(29):18019-22. PubMed ID: 9660756
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit.
    Huang LE; Arany Z; Livingston DM; Bunn HF
    J Biol Chem; 1996 Dec; 271(50):32253-9. PubMed ID: 8943284
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mitogen-activated protein kinase kinase inhibitor PD98059 blocks the trans-activation but not the stabilization or DNA binding ability of hypoxia-inducible factor-1alpha.
    Hur E; Chang KY; Lee E; Lee SK; Park H
    Mol Pharmacol; 2001 May; 59(5):1216-24. PubMed ID: 11306706
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells.
    Ameri K; Lewis CE; Raida M; Sowter H; Hai T; Harris AL
    Blood; 2004 Mar; 103(5):1876-82. PubMed ID: 14604972
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells.
    Tacchini L; Dansi P; Matteucci E; Desiderio MA
    Carcinogenesis; 2001 Sep; 22(9):1363-71. PubMed ID: 11532856
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Normoxic stabilization of hypoxia-inducible factor-1 expression and activity: redox-dependent effect of nitrogen oxides.
    Palmer LA; Gaston B; Johns RA
    Mol Pharmacol; 2000 Dec; 58(6):1197-203. PubMed ID: 11093754
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1alpha.
    Chilov D; Camenisch G; Kvietikova I; Ziegler U; Gassmann M; Wenger RH
    J Cell Sci; 1999 Apr; 112 ( Pt 8)():1203-12. PubMed ID: 10085255
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.
    Cockman ME; Masson N; Mole DR; Jaakkola P; Chang GW; Clifford SC; Maher ER; Pugh CW; Ratcliffe PJ; Maxwell PH
    J Biol Chem; 2000 Aug; 275(33):25733-41. PubMed ID: 10823831
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.
    Mole DR; Maxwell PH; Pugh CW; Ratcliffe PJ
    IUBMB Life; 2001 Jul; 52(1-2):43-7. PubMed ID: 11795592
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.
    Maxwell PH; Wiesener MS; Chang GW; Clifford SC; Vaux EC; Cockman ME; Wykoff CC; Pugh CW; Maher ER; Ratcliffe PJ
    Nature; 1999 May; 399(6733):271-5. PubMed ID: 10353251
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 38.