These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

121 related articles for article (PubMed ID: 9288163)

  • 1. Terbenzimidazoles: influence of 2"-, 4-, and 5-substituents on cytotoxicity and relative potency as topoisomerase I poisons.
    Kim JS; Yu C; Liu A; Liu LF; LaVoie EJ
    J Med Chem; 1997 Aug; 40(18):2818-24. PubMed ID: 9288163
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Substituted 2,5'-Bi-1H-benzimidazoles: topoisomerase I inhibition and cytotoxicity.
    Kim JS; Gatto B; Yu C; Liu A; Liu LF; LaVoie EJ
    J Med Chem; 1996 Feb; 39(4):992-8. PubMed ID: 8632422
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Topoisomerase I inhibition and cytotoxicity of 5-bromo- and 5-phenylterbenzimidazoles.
    Rangarajan M; Kim JS; Sim SP; Liu A; Liu LF; Lavoie EJ
    Bioorg Med Chem; 2000 Nov; 8(11):2591-600. PubMed ID: 11092544
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structure-activity relationships for substituted bis(acridine-4-carboxamides): a new class of anticancer agents.
    Gamage SA; Spicer JA; Atwell GJ; Finlay GJ; Baguley BC; Denny WA
    J Med Chem; 1999 Jul; 42(13):2383-93. PubMed ID: 10395479
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 11H-Isoquino[4,3-c]cinnolin-12-ones; novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity.
    Ruchelman AL; Singh SK; Ray A; Wu X; Yang JM; Zhou N; Liu A; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2004 Feb; 12(4):795-806. PubMed ID: 14759740
    [TBL] [Abstract][Full Text] [Related]  

  • 6. DNA minor groove binding-directed poisoning of human DNA topoisomerase I by terbenzimidazoles.
    Xu Z; Li TK; Kim JS; LaVoie EJ; Breslauer KJ; Liu LF; Pilch DS
    Biochemistry; 1998 Mar; 37(10):3558-66. PubMed ID: 9521677
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Substitution at the F-ring N-imide of the indolocarbazole antitumor drug NB-506 increases the cytotoxicity, DNA binding, and topoisomerase I inhibition activities.
    Bailly C; Qu X; Chaires JB; Colson P; Houssier C; Ohkubo M; Nishimura S; Yoshinari T
    J Med Chem; 1999 Jul; 42(15):2927-35. PubMed ID: 10425102
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.
    Fox BM; Xiao X; Antony S; Kohlhagen G; Pommier Y; Staker BL; Stewart L; Cushman M
    J Med Chem; 2003 Jul; 46(15):3275-82. PubMed ID: 12852757
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Quantitative structure-activity relationships on 5-substituted terbenzimidazoles as topoisomerase I poisons and antitumor agents.
    Kim JS; Sun Q; Yu C; Liu A; Liu LF; LaVoie EJ
    Bioorg Med Chem; 1998 Feb; 6(2):163-72. PubMed ID: 9547939
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis of cytotoxic indenoisoquinoline topoisomerase I poisons.
    Strumberg D; Pommier Y; Paull K; Jayaraman M; Nagafuji P; Cushman M
    J Med Chem; 1999 Feb; 42(3):446-57. PubMed ID: 9986716
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 5,7-Disubstituted analogues of the mixed topoisomerase I/II poison N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA): DNA binding and patterns of cytotoxicity.
    Spicer JA; Finlay GJ; Baguley BC; Velea L; Graves DE; Denny WA
    Anticancer Drug Des; 1999 Feb; 14(1):37-45. PubMed ID: 10363026
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Antitumor agents. 194. Synthesis and biological evaluations of 4-beta-mono-, -di-, and -trisubstituted aniline-4'-O-demethyl-podophyllotoxin and related compounds with improved pharmacological profiles.
    Zhu XK; Guan J; Tachibana Y; Bastow KF; Cho SJ; Cheng HH; Cheng YC; Gurwith M; Lee KH
    J Med Chem; 1999 Jul; 42(13):2441-6. PubMed ID: 10395485
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 2,4,6-Trisubstituted pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.
    Basnet A; Thapa P; Karki R; Na Y; Jahng Y; Jeong BS; Jeong TC; Lee CS; Lee ES
    Bioorg Med Chem; 2007 Jul; 15(13):4351-9. PubMed ID: 17493824
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The 1'-substituent on the anilino ring of the antitumor drug amsacrine is a critical element for topoisomerase II inhibition and cytotoxicity.
    Rene B; Fosse P; Khelifa T; Jacquemin-Sablon A; Bailly C
    Mol Pharmacol; 1996 Feb; 49(2):343-50. PubMed ID: 8632768
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and biological activity of novel inhibitors of topoisomerase I: 2-aryl-substituted 2-bis-1H-benzimidazoles.
    Singh M; Tandon V
    Eur J Med Chem; 2011 Feb; 46(2):659-69. PubMed ID: 21186067
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
    Spicer JA; Gamage SA; Atwell GJ; Finlay GJ; Baguley BC; Denny WA
    J Med Chem; 1997 Jun; 40(12):1919-29. PubMed ID: 9191970
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31).
    Satyanarayana M; Feng W; Cheng L; Liu AA; Tsai YC; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2008 Aug; 16(16):7824-31. PubMed ID: 18676151
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cytotoxic compounds from Annonaceus species as DNA topoisomerase I poisons.
    López-Lázaro M; Martín-Cordero C; Bermejo A; Cortes D; Ayuso MJ
    Anticancer Res; 2001; 21(5):3493-7. PubMed ID: 11848514
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity.
    Ruchelman AL; Zhu S; Zhou N; Liu A; Liu LF; LaVoie EJ
    Bioorg Med Chem Lett; 2004 Nov; 14(22):5585-9. PubMed ID: 15482929
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 2"-Substituted 5-phenylterbenzimidazoles as topoisomerase I poisons.
    Rangarajan M; Kim JS; Jin S; Sim SP; Liu A; Pilch DS; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2000 Jun; 8(6):1371-82. PubMed ID: 10896114
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.