BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

198 related articles for article (PubMed ID: 9295319)

  • 1. Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 (IL-6).IL-6 receptor.gp130 complex.
    Horsten U; Müller-Newen G; Gerhartz C; Wollmer A; Wijdenes J; Heinrich PC; Grötzinger J
    J Biol Chem; 1997 Sep; 272(38):23748-57. PubMed ID: 9295319
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes.
    Kurth I; Horsten U; Pflanz S; Dahmen H; Küster A; Grötzinger J; Heinrich PC; Müller-Newen G
    J Immunol; 1999 Feb; 162(3):1480-7. PubMed ID: 9973404
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of amino acid residues of gp130 signal transducer and gp80 alpha receptor subunit that are involved in ligand binding and signaling by human herpesvirus 8-encoded interleukin-6.
    Li H; Nicholas J
    J Virol; 2002 Jun; 76(11):5627-36. PubMed ID: 11991991
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling.
    Paonessa G; Graziani R; De Serio A; Savino R; Ciapponi L; Lahm A; Salvati AL; Toniatti C; Ciliberto G
    EMBO J; 1995 May; 14(9):1942-51. PubMed ID: 7744001
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Two different epitopes of the signal transducer gp130 sequentially cooperate on IL-6-induced receptor activation.
    Pflanz S; Kurth I; Grötzinger J; Heinrich PC; Müller-Newen G
    J Immunol; 2000 Dec; 165(12):7042-9. PubMed ID: 11120832
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions.
    Dahmen H; Horsten U; Küster A; Jacques Y; Minvielle S; Kerr IM; Ciliberto G; Paonessa G; Heinrich PC; Müller-Newen G
    Biochem J; 1998 May; 331 ( Pt 3)(Pt 3):695-702. PubMed ID: 9560294
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130.
    Kurth I; Horsten U; Pflanz S; Timmermann A; Küster A; Dahmen H; Tacken I; Heinrich PC; Müller-Newen G
    J Immunol; 2000 Jan; 164(1):273-82. PubMed ID: 10605021
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor.
    Dittrich E; Haft CR; Muys L; Heinrich PC; Graeve L
    J Biol Chem; 1996 Mar; 271(10):5487-94. PubMed ID: 8621406
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of single amino acid residues of human IL-6 involved in receptor binding and signal initiation.
    Ehlers M; Grötzinger J; Fischer M; Bos HK; Brakenhoff JP; Rose-John S
    J Interferon Cytokine Res; 1996 Aug; 16(8):569-76. PubMed ID: 8877726
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130.
    Yawata H; Yasukawa K; Natsuka S; Murakami M; Yamasaki K; Hibi M; Taga T; Kishimoto T
    EMBO J; 1993 Apr; 12(4):1705-12. PubMed ID: 8467812
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation.
    Savino R; Lahm A; Salvati AL; Ciapponi L; Sporeno E; Altamura S; Paonessa G; Toniatti C; Ciliberto G
    EMBO J; 1994 Mar; 13(6):1357-67. PubMed ID: 7511100
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling.
    Li H; Wang H; Nicholas J
    J Virol; 2001 Apr; 75(7):3325-34. PubMed ID: 11238858
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL-6 and the IL-6 receptor.
    Horsten U; Schmitz-Van de Leur H; Müllberg J; Heinrich PC; Rose-John S
    FEBS Lett; 1995 Feb; 360(1):43-6. PubMed ID: 7875298
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A single amino acid substitution (Trp(666)-->Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1, and dominantly impairs signal transduction.
    Haan C; Hermanns HM; Heinrich PC; Behrmann I
    Biochem J; 2000 Jul; 349(Pt 1):261-6. PubMed ID: 10861237
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction.
    Schmitz J; Dahmen H; Grimm C; Gendo C; Müller-Newen G; Heinrich PC; Schaper F
    J Immunol; 2000 Jan; 164(2):848-54. PubMed ID: 10623831
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Interleukin-11 signals through the formation of a hexameric receptor complex.
    Barton VA; Hall MA; Hudson KR; Heath JK
    J Biol Chem; 2000 Nov; 275(46):36197-203. PubMed ID: 10948192
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A complex of the soluble interleukin-6 receptor and interleukin-6 is internalized via the signal transducer gp130.
    Graeve L; Korolenko TA; Hemmann U; Weiergräber O; Dittrich E; Heinrich PC
    FEBS Lett; 1996 Dec; 399(1-2):131-4. PubMed ID: 8980136
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Influence of interleukin-6 (IL-6) dimerization on formation of the high affinity hexameric IL-6.receptor complex.
    Ward LD; Hammacher A; Howlett GJ; Matthews JM; Fabri L; Moritz RL; Nice EC; Weinstock J; Simpson RJ
    J Biol Chem; 1996 Aug; 271(33):20138-44. PubMed ID: 8702737
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The N-terminus of gp130 is critical for the formation of the high-affinity interleukin-6 receptor complex.
    Moritz RL; Ward LD; Tu GF; Fabri LJ; Ji H; Yasukawa K; Simpson RJ
    Growth Factors; 1999; 16(4):265-78. PubMed ID: 10427501
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor.
    Dittrich E; Rose-John S; Gerhartz C; Müllberg J; Stoyan T; Yasukawa K; Heinrich PC; Graeve L
    J Biol Chem; 1994 Jul; 269(29):19014-20. PubMed ID: 8034658
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.