327 related articles for article (PubMed ID: 9305589)
21. Cytochrome P-450-mediated activation and irreversible binding of the antiestrogen tamoxifen to proteins in rat and human liver: possible involvement of flavin-containing monooxygenases in tamoxifen activation.
Mani C; Kupfer D
Cancer Res; 1991 Nov; 51(22):6052-8. PubMed ID: 1933868
[TBL] [Abstract][Full Text] [Related]
22. Covalent binding of phenytoin to protein and modulation of phenytoin metabolism by thiols in A/J mouse liver microsomes.
Roy D; Snodgrass WR
J Pharmacol Exp Ther; 1990 Mar; 252(3):895-900. PubMed ID: 2319474
[TBL] [Abstract][Full Text] [Related]
23. Phenytoin metabolic activation: role of cytochrome P-450, glutathione, age, and sex in rats and mice.
Roy D; Snodgrass WR
Res Commun Chem Pathol Pharmacol; 1988 Feb; 59(2):173-90. PubMed ID: 3358010
[TBL] [Abstract][Full Text] [Related]
24. In vitro biotransformation and genotoxicity of the drinking water disinfection byproduct bromodichloromethane: DNA binding mediated by glutathione transferase theta 1-1.
Ross MK; Pegram RA
Toxicol Appl Pharmacol; 2004 Mar; 195(2):166-81. PubMed ID: 14998683
[TBL] [Abstract][Full Text] [Related]
25. Roles of human hepatic cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac.
Tang W; Stearns RA; Wang RW; Chiu SH; Baillie TA
Chem Res Toxicol; 1999 Feb; 12(2):192-9. PubMed ID: 10027798
[TBL] [Abstract][Full Text] [Related]
26. Covalent binding of a reactive metabolite derived from propranolol and its active metabolite 4-hydroxypropranolol to hepatic microsomal proteins of the rat.
Narimatsu S; Arai T; Watanabe T; Masubuchi Y; Horie T; Suzuki T; Ishikawa T; Tsutsui M; Kumagai Y; Cho AK
Chem Res Toxicol; 1997 Mar; 10(3):289-95. PubMed ID: 9084908
[TBL] [Abstract][Full Text] [Related]
27. Bioactivation of flutamide metabolites by human liver microsomes.
Kang P; Dalvie D; Smith E; Zhou S; Deese A; Nieman JA
Drug Metab Dispos; 2008 Jul; 36(7):1425-37. PubMed ID: 18411402
[TBL] [Abstract][Full Text] [Related]
28. NTP technical report on the toxicity and metabolism studies of chloral hydrate (CAS No. 302-17-0). Administered by gavage to F344/N rats and B6C3F1 mice.
Beland FA
Toxic Rep Ser; 1999 Aug; (59):1-66, A1-E7. PubMed ID: 11803702
[TBL] [Abstract][Full Text] [Related]
29. Interactions between folate metabolism, phenytoin metabolism, and liver microsomal cytochrome P450.
Billings RE
Drug Nutr Interact; 1984; 3(1):21-32. PubMed ID: 6510238
[TBL] [Abstract][Full Text] [Related]
30. Rat microsomes activating the anticancer drug ellipticine to species covalently binding to deoxyguanosine in DNA are a suitable model mimicking ellipticine bioactivation in humans.
Stiborová M; Stiborová-Rupertová M; Borek-Dohalská L; Wiessler M; Frei E
Chem Res Toxicol; 2003 Jan; 16(1):38-47. PubMed ID: 12693029
[TBL] [Abstract][Full Text] [Related]
31. Bioactivation of estrone and its catechol metabolites to quinoid-glutathione conjugates in rat liver microsomes.
Iverson SL; Shen L; Anlar N; Bolton JL
Chem Res Toxicol; 1996 Mar; 9(2):492-9. PubMed ID: 8839054
[TBL] [Abstract][Full Text] [Related]
32. Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s.
Wen B; Ma L; Zhu M
Chem Biol Interact; 2008 May; 173(1):59-67. PubMed ID: 18359012
[TBL] [Abstract][Full Text] [Related]
33. Cytochrome P4502C11 is a target of diclofenac covalent binding in rats.
Shen S; Hargus SJ; Martin BM; Pohl LR
Chem Res Toxicol; 1997 Apr; 10(4):420-3. PubMed ID: 9114979
[TBL] [Abstract][Full Text] [Related]
34. Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
Tang W; Stearns RA; Bandiera SM; Zhang Y; Raab C; Braun MP; Dean DC; Pang J; Leung KH; Doss GA; Strauss JR; Kwei GY; Rushmore TH; Chiu SH; Baillie TA
Drug Metab Dispos; 1999 Mar; 27(3):365-72. PubMed ID: 10064567
[TBL] [Abstract][Full Text] [Related]
35. A novel bioactivation pathway for 2-[2-(2,6-dichlorophenyl)aminophenyl]ethanoic acid (diclofenac) initiated by cytochrome P450-mediated oxidative decarboxylation.
Grillo MP; Ma J; Teffera Y; Waldon DJ
Drug Metab Dispos; 2008 Sep; 36(9):1740-4. PubMed ID: 18541695
[TBL] [Abstract][Full Text] [Related]
36. Cytochrome P-450-dependent bioactivation of 1,1-dichloroethylene to a reactive epoxide in human lung and liver microsomes.
Dowsley TF; Reid K; Petsikas D; Ulreich JB; Fisher RL; Forkert PG
J Pharmacol Exp Ther; 1999 May; 289(2):641-8. PubMed ID: 10215634
[TBL] [Abstract][Full Text] [Related]
37. Covalent binding of metabolites of 4-ipomeanol to rabbit pulmonary and hepatic microsomal proteins and to the enzymes of the pulmonary cytochrome P-450-dependent monooxygenase system.
Slaughter SR; Statham CN; Philpot RM; Boyd MR
J Pharmacol Exp Ther; 1983 Jan; 224(1):252-7. PubMed ID: 6848746
[TBL] [Abstract][Full Text] [Related]
38. Hydroxylation of 5,5-diphenylhydantoin (phenytoin) by dog liver microsomes.
Butler TC; Dudley KH; Mitchell GN; Johnson D
Arch Int Pharmacodyn Ther; 1977 Jul; 228(1):4-9. PubMed ID: 21639
[TBL] [Abstract][Full Text] [Related]
39. In vitro bioactivation of phenytoin to a reactive free radical intermediate by prostaglandin synthetase, horseradish peroxidase, and thyroid peroxidase.
Kubow S; Wells PG
Mol Pharmacol; 1989 Apr; 35(4):504-11. PubMed ID: 2539558
[TBL] [Abstract][Full Text] [Related]
40. Metabolism and bioactivation of clozapine by human liver in vitro.
Pirmohamed M; Williams D; Madden S; Templeton E; Park BK
J Pharmacol Exp Ther; 1995 Mar; 272(3):984-90. PubMed ID: 7891353
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
