206 related articles for article (PubMed ID: 9307289)
1. Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function.
Shao RG; Cao CX; Shimizu T; O'Connor PM; Kohn KW; Pommier Y
Cancer Res; 1997 Sep; 57(18):4029-35. PubMed ID: 9307289
[TBL] [Abstract][Full Text] [Related]
2. UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.
Wang Q; Fan S; Eastman A; Worland PJ; Sausville EA; O'Connor PM
J Natl Cancer Inst; 1996 Jul; 88(14):956-65. PubMed ID: 8667426
[TBL] [Abstract][Full Text] [Related]
3. Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic catastrophe.
Tse AN; Schwartz GK
Cancer Res; 2004 Sep; 64(18):6635-44. PubMed ID: 15374978
[TBL] [Abstract][Full Text] [Related]
4. Enhancement of camptothecin-induced cytotoxicity with UCN-01 in breast cancer cells: abrogation of S/G(2) arrest.
Jones CB; Clements MK; Wasi S; Daoud SS
Cancer Chemother Pharmacol; 2000; 45(3):252-8. PubMed ID: 10663644
[TBL] [Abstract][Full Text] [Related]
5. Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells.
Shao RG; Cao CX; Pommier Y
Acta Pharmacol Sin; 2004 Jun; 25(6):756-62. PubMed ID: 15169628
[TBL] [Abstract][Full Text] [Related]
6. Implications of p53 in growth arrest and apoptosis on combined treatment of human Mammary epithelial cells with topotecan and UCN-01.
Redkar A; Mixter P; Daoud SS
J Exp Ther Oncol; 2004 Oct; 4(3):213-22. PubMed ID: 15724841
[TBL] [Abstract][Full Text] [Related]
7. 7-Hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53.
Shao RG; Shimizu T; Pommier Y
Exp Cell Res; 1997 Aug; 234(2):388-97. PubMed ID: 9260909
[TBL] [Abstract][Full Text] [Related]
8. Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor.
Bunch RT; Eastman A
Clin Cancer Res; 1996 May; 2(5):791-7. PubMed ID: 9816232
[TBL] [Abstract][Full Text] [Related]
9. UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G(2) checkpoint abrogation.
Sugiyama K; Shimizu M; Akiyama T; Tamaoki T; Yamaguchi K; Takahashi R; Eastman A; Akinaga S
Int J Cancer; 2000 Mar; 85(5):703-9. PubMed ID: 10699952
[TBL] [Abstract][Full Text] [Related]
10. 7-Hydroxystaurosporine (UCN-01) causes redistribution of proliferating cell nuclear antigen and abrogates cisplatin-induced S-phase arrest in Chinese hamster ovary cells.
Bunch RT; Eastman A
Cell Growth Differ; 1997 Jul; 8(7):779-88. PubMed ID: 9218872
[TBL] [Abstract][Full Text] [Related]
11. Inactivation of p53 increases the cytotoxicity of camptothecin in human colon HCT116 and breast MCF-7 cancer cells.
Gupta M; Fan S; Zhan Q; Kohn KW; O'Connor PM; Pommier Y
Clin Cancer Res; 1997 Sep; 3(9):1653-60. PubMed ID: 9815856
[TBL] [Abstract][Full Text] [Related]
12. UCN-01 and camptothecin induce DNA double-strand breaks in p53 mutant tumor cells, but not in normal or p53 negative epithelial cells.
Jones CB; Clements MK; Redkar A; Daoud SS
Int J Oncol; 2000 Nov; 17(5):1043-51. PubMed ID: 11029511
[TBL] [Abstract][Full Text] [Related]
13. Correlations between S and G2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells.
Goldwasser F; Shimizu T; Jackman J; Hoki Y; O'Connor PM; Kohn KW; Pommier Y
Cancer Res; 1996 Oct; 56(19):4430-7. PubMed ID: 8813137
[TBL] [Abstract][Full Text] [Related]
14. Cell cycle-dependent potentiation of cisplatin by UCN-01 in non-small-cell lung carcinoma.
Mack PC; Gandara DR; Lau AH; Lara PN; Edelman MJ; Gumerlock PH
Cancer Chemother Pharmacol; 2003 Apr; 51(4):337-48. PubMed ID: 12721762
[TBL] [Abstract][Full Text] [Related]
15. A novel indolocarbazole, ICP-1, abrogates DNA damage-induced cell cycle arrest and enhances cytotoxicity: similarities and differences to the cell cycle checkpoint abrogator UCN-01.
Eastman A; Kohn EA; Brown MK; Rathman J; Livingstone M; Blank DH; Gribble GW
Mol Cancer Ther; 2002 Oct; 1(12):1067-78. PubMed ID: 12481430
[TBL] [Abstract][Full Text] [Related]
16. Distinct roles for p53 transactivation and repression in preventing UCN-01-mediated abrogation of DNA damage-induced arrest at S and G2 cell cycle checkpoints.
Levesque AA; Kohn EA; Bresnick E; Eastman A
Oncogene; 2005 May; 24(23):3786-96. PubMed ID: 15782134
[TBL] [Abstract][Full Text] [Related]
17. Abrogation of the S phase DNA damage checkpoint results in S phase progression or premature mitosis depending on the concentration of 7-hydroxystaurosporine and the kinetics of Cdc25C activation.
Kohn EA; Ruth ND; Brown MK; Livingstone M; Eastman A
J Biol Chem; 2002 Jul; 277(29):26553-64. PubMed ID: 11953432
[TBL] [Abstract][Full Text] [Related]
18. Defective p53 signaling in p53 wild-type tumors attenuates p21waf1 induction and cyclin B repression rendering them sensitive to Chk1 inhibitors that abrogate DNA damage-induced S and G2 arrest.
Levesque AA; Fanous AA; Poh A; Eastman A
Mol Cancer Ther; 2008 Feb; 7(2):252-62. PubMed ID: 18281511
[TBL] [Abstract][Full Text] [Related]
19. G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells.
Akiyama T; Yoshida T; Tsujita T; Shimizu M; Mizukami T; Okabe M; Akinaga S
Cancer Res; 1997 Apr; 57(8):1495-501. PubMed ID: 9108451
[TBL] [Abstract][Full Text] [Related]
20. p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.
Furuta T; Hayward RL; Meng LH; Takemura H; Aune GJ; Bonner WM; Aladjem MI; Kohn KW; Pommier Y
Oncogene; 2006 May; 25(20):2839-49. PubMed ID: 16407843
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
