These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

168 related articles for article (PubMed ID: 9312066)

  • 1. Neuronal expression of beta-amyloid precursor protein Alzheimer mutations causes intracellular accumulation of a C-terminal fragment containing both the amyloid beta and cytoplasmic domains.
    McPhie DL; Lee RK; Eckman CB; Olstein DH; Durham SP; Yager D; Younkin SG; Wurtman RJ; Neve RL
    J Biol Chem; 1997 Oct; 272(40):24743-6. PubMed ID: 9312066
    [TBL] [Abstract][Full Text] [Related]  

  • 2. beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations.
    McPhie DL; Golde T; Eckman CB; Yager D; Brant JB; Neve RL
    Brain Res Mol Brain Res; 2001 Dec; 97(1):103-13. PubMed ID: 11744168
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence.
    De Strooper B; Simons M; Multhaup G; Van Leuven F; Beyreuther K; Dotti CG
    EMBO J; 1995 Oct; 14(20):4932-8. PubMed ID: 7588622
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Enhanced BK-induced calcium responsiveness in PC12 cells expressing the C100 fragment of the amyloid precursor protein.
    Pascale A; Bhagavan S; Nelson TJ; Neve RL; McPhie DL; Etcheberrigaray R
    Brain Res Mol Brain Res; 1999 Oct; 72(2):205-13. PubMed ID: 10529479
    [TBL] [Abstract][Full Text] [Related]  

  • 5. APP processing induced by herpes simplex virus type 1 (HSV-1) yields several APP fragments in human and rat neuronal cells.
    De Chiara G; Marcocci ME; Civitelli L; Argnani R; Piacentini R; Ripoli C; Manservigi R; Grassi C; Garaci E; Palamara AT
    PLoS One; 2010 Nov; 5(11):e13989. PubMed ID: 21085580
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells.
    Wiltfang J; Esselmann H; Cupers P; Neumann M; Kretzschmar H; Beyermann M; Schleuder D; Jahn H; Rüther E; Kornhuber J; Annaert W; De Strooper B; Saftig P
    J Biol Chem; 2001 Nov; 276(46):42645-57. PubMed ID: 11526104
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Secretion and intracellular generation of truncated Abeta in beta-site amyloid-beta precursor protein-cleaving enzyme expressing human neurons.
    Lee EB; Skovronsky DM; Abtahian F; Doms RW; Lee VM
    J Biol Chem; 2003 Feb; 278(7):4458-66. PubMed ID: 12480937
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.
    Siman R; Reaume AG; Savage MJ; Trusko S; Lin YG; Scott RW; Flood DG
    J Neurosci; 2000 Dec; 20(23):8717-26. PubMed ID: 11102478
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein.
    Haass C; Capell A; Citron M; Teplow DB; Selkoe DJ
    J Biol Chem; 1995 Mar; 270(11):6186-92. PubMed ID: 7890753
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.
    Iwata H; Tomita T; Maruyama K; Iwatsubo T
    J Biol Chem; 2001 Jun; 276(24):21678-85. PubMed ID: 11283011
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Expression of potentially amyloidogenic derivatives of the Alzheimer amyloid precursor protein in cultured 293 cells.
    Johnstone EM; Oltersdorf T; Bales KR; Chaney MO; Santerre RF; Little SP
    Neurosci Lett; 1994 Oct; 180(2):151-4. PubMed ID: 7700569
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain.
    Furukawa K; Sopher BL; Rydel RE; Begley JG; Pham DG; Martin GM; Fox M; Mattson MP
    J Neurochem; 1996 Nov; 67(5):1882-96. PubMed ID: 8863493
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants.
    Gorman PM; Kim S; Guo M; Melnyk RA; McLaurin J; Fraser PE; Bowie JU; Chakrabartty A
    BMC Neurosci; 2008 Jan; 9():17. PubMed ID: 18234110
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein.
    Nunan J; Williamson NA; Hill AF; Sernee MF; Masters CL; Small DH
    J Neurosci Res; 2003 Nov; 74(3):378-85. PubMed ID: 14598314
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Evaluation of the Expression of Amyloid Precursor Protein and the Ratio of Secreted Amyloid Beta 42 to Amyloid Beta 40 in SH-SY5Y Cells Stably Transfected with Wild-Type, Single-Mutant and Double-Mutant Forms of the APP Gene for the Study of Alzheimer's Disease Pathology.
    Pahrudin Arrozi A; Shukri SNS; Wan Ngah WZ; Mohd Yusof YA; Ahmad Damanhuri MH; Makpol S
    Appl Biochem Biotechnol; 2017 Nov; 183(3):853-866. PubMed ID: 28417423
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Astrocytes down-regulate neuronal beta-amyloid precursor protein expression and modify its processing in an apolipoprotein E isoform-specific manner.
    Vincent B; Smith JD
    Eur J Neurosci; 2001 Jul; 14(2):256-66. PubMed ID: 11553277
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(beta)42 from isolated intact nerve terminals.
    Kim SH; Fraser PE; Westaway D; St George-Hyslop PH; Ehrlich ME; Gandy S
    J Neurosci; 2010 Mar; 30(11):3870-5. PubMed ID: 20237257
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The amyloid beta protein precursor mutations linked to familial Alzheimer's disease alter processing in a way that fosters amyloid deposition.
    Younkin SG
    Tohoku J Exp Med; 1994 Nov; 174(3):217-23. PubMed ID: 7761987
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo.
    Gandy S; Zhang YW; Ikin A; Schmidt SD; Bogush A; Levy E; Sheffield R; Nixon RA; Liao FF; Mathews PM; Xu H; Ehrlich ME
    J Neurochem; 2007 Aug; 102(3):619-26. PubMed ID: 17630980
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.
    Shi XP; Tugusheva K; Bruce JE; Lucka A; Chen-Dodson E; Hu B; Wu GX; Price E; Register RB; Lineberger J; Miller R; Tang MJ; Espeseth A; Kahana J; Wolfe A; Crouthamel MC; Sankaranarayanan S; Simon A; Chen L; Lai MT; Pietrak B; DiMuzio J; Li Y; Xu M; Huang Q; Garsky V; Sardana MK; Hazuda DJ
    J Alzheimers Dis; 2005 Apr; 7(2):139-48; discussion 173-80. PubMed ID: 15851852
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.