153 related articles for article (PubMed ID: 9337081)
1. Measurement of deoxyuridine triphosphate and thymidine triphosphate in the extracts of thymidylate synthase-inhibited cells using a modified DNA polymerase assay.
Horowitz RW; Zhang H; Schwartz EL; Ladner RD; Wadler S
Biochem Pharmacol; 1997 Sep; 54(5):635-8. PubMed ID: 9337081
[TBL] [Abstract][Full Text] [Related]
2. Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells.
Aherne GW; Hardcastle A; Raynaud F; Jackman AL
Biochem Pharmacol; 1996 May; 51(10):1293-301. PubMed ID: 8787544
[TBL] [Abstract][Full Text] [Related]
3. Mechanisms of resistance to N-[5-[N-(3,4-dihydro-2-methyl-4- oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line.
Lu K; Yin MB; McGuire JJ; Bonmassar E; Rustum YM
Biochem Pharmacol; 1995 Jul; 50(3):391-8. PubMed ID: 7646540
[TBL] [Abstract][Full Text] [Related]
4. The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition.
Webley SD; Welsh SJ; Jackman AL; Aherne GW
Br J Cancer; 2001 Aug; 85(3):446-52. PubMed ID: 11487279
[TBL] [Abstract][Full Text] [Related]
5. Expression of uracil DNA glycosylase (UDG) does not affect cellular sensitivity to thymidylate synthase (TS) inhibition.
Welsh SJ; Hobbs S; Aherne GW
Eur J Cancer; 2003 Feb; 39(3):378-87. PubMed ID: 12565992
[TBL] [Abstract][Full Text] [Related]
6. Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.
Jackman AL; Kelland LR; Kimbell R; Brown M; Gibson W; Aherne GW; Hardcastle A; Boyle FT
Br J Cancer; 1995 May; 71(5):914-24. PubMed ID: 7537518
[TBL] [Abstract][Full Text] [Related]
7. Mechanism of cell death following thymidylate synthase inhibition: 2'-deoxyuridine-5'-triphosphate accumulation, DNA damage, and growth inhibition following exposure to CB3717 and dipyridamole.
Curtin NJ; Harris AL; Aherne GW
Cancer Res; 1991 May; 51(9):2346-52. PubMed ID: 2015598
[TBL] [Abstract][Full Text] [Related]
8. Effects of thymidylate synthase inhibition on thymidine kinase activity and nucleoside transporter expression.
Pressacco J; Mitrovski B; Erlichman C; Hedley DW
Cancer Res; 1995 Apr; 55(7):1505-8. PubMed ID: 7882359
[TBL] [Abstract][Full Text] [Related]
9. The quantitation by radioimmunoassay of 2'-deoxyuridine 5'-triphosphate in extracts of thymidylate synthase-inhibited cells.
Piall EM; Curtin NJ; Aherne GW; Harris AL; Marks V
Anal Biochem; 1989 Mar; 177(2):347-52. PubMed ID: 2729554
[TBL] [Abstract][Full Text] [Related]
10. Prodrugs of thymidylate synthase inhibitors: potential for antibody directed enzyme prodrug therapy (ADEPT).
Springer CJ; Bavetsias V; Jackman AL; Boyle FT; Marshall D; Pedley RB; Bisset GM
Anticancer Drug Des; 1996 Dec; 11(8):625-36. PubMed ID: 9022750
[TBL] [Abstract][Full Text] [Related]
11. DNA damage and p53 induction do not cause ZD1694-induced cell cycle arrest in human colon carcinoma cells.
Matsui SI; Arredondo MA; Wrzosek C; Rustum YM
Cancer Res; 1996 Oct; 56(20):4715-23. PubMed ID: 8840989
[TBL] [Abstract][Full Text] [Related]
12. Molecular characterisation of two cell lines selected for resistance to the folate-based thymidylate synthase inhibitor, ZD1694.
Freemantle SJ; Jackman AL; Kelland LR; Calvert AH; Lunec J
Br J Cancer; 1995 May; 71(5):925-30. PubMed ID: 7537519
[TBL] [Abstract][Full Text] [Related]
13. Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA.
Grogan BC; Parker JB; Guminski AF; Stivers JT
Biochemistry; 2011 Feb; 50(5):618-27. PubMed ID: 21222484
[TBL] [Abstract][Full Text] [Related]
14. Contrasting patterns of DNA fragmentation induced by thymidylate synthase inhibitors, ZD1694 and AG-331.
Panadero A; Yin MB; Voigt W; Rustum YM
Oncol Res; 1995; 7(2):73-81. PubMed ID: 7579730
[TBL] [Abstract][Full Text] [Related]
15. p53 and WAF1 are induced and Rb protein is hypophosphorylated during cell growth inhibition by the thymidylate synthase inhibitor ZD1694 (Tomudex).
Yin MB; Voigt W; Panadero A; Vanhoefer U; Frank C; Pajovic S; Azizkhan J; Rustum YM
Mol Pharmacol; 1997 Apr; 51(4):630-6. PubMed ID: 9106628
[TBL] [Abstract][Full Text] [Related]
16. Effect of adding the topoisomerase I poison 7-ethyl-10-hydroxycamptothecin (SN-38) to 5-fluorouracil and folinic acid in HCT-8 cells: elevated dTTP pools and enhanced cytotoxicity.
Mullany S; Svingen PA; Kaufmann SH; Erlichman C
Cancer Chemother Pharmacol; 1998; 42(5):391-9. PubMed ID: 9771954
[TBL] [Abstract][Full Text] [Related]
17. Cytotoxic and biochemical implications of combining AZT and AG-331.
Pressacco J; Mitrovski B; Erlichman C
Cancer Chemother Pharmacol; 1995; 35(5):387-90. PubMed ID: 7850919
[TBL] [Abstract][Full Text] [Related]
18. ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.
Jackman AL; Taylor GA; Gibson W; Kimbell R; Brown M; Calvert AH; Judson IR; Hughes LR
Cancer Res; 1991 Oct; 51(20):5579-86. PubMed ID: 1913676
[TBL] [Abstract][Full Text] [Related]
19. Resistance to fluorodeoxyuridine-induced DNA damage and cytotoxicity correlates with an elevation of deoxyuridine triphosphatase activity and failure to accumulate deoxyuridine triphosphate.
Canman CE; Lawrence TS; Shewach DS; Tang HY; Maybaum J
Cancer Res; 1993 Nov; 53(21):5219-24. PubMed ID: 8221659
[TBL] [Abstract][Full Text] [Related]
20. Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331.
Webley SD; Hardcastle A; Ladner RD; Jackman AL; Aherne GW
Br J Cancer; 2000 Sep; 83(6):792-9. PubMed ID: 10952785
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
