BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

199 related articles for article (PubMed ID: 9337850)

  • 1. Human phosphodiesterase 4A: characterization of full-length and truncated enzymes expressed in COS cells.
    Owens RJ; Catterall C; Batty D; Jappy J; Russell A; Smith B; O'Connell J; Perry MJ
    Biochem J; 1997 Aug; 326 ( Pt 1)(Pt 1):53-60. PubMed ID: 9337850
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Detailed characterization of a purified type 4 phosphodiesterase, HSPDE4B2B: differentiation of high- and low-affinity (R)-rolipram binding.
    Rocque WJ; Holmes WD; Patel IR; Dougherty RW; Ittoop O; Overton L; Hoffman CR; Wisely GB; Willard DH; Luther MA
    Protein Expr Purif; 1997 Mar; 9(2):191-202. PubMed ID: 9056484
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of inhibitor binding sites of the cAMP-specific phosphodiesterase 4.
    Richter W; Unciuleac L; Hermsdorf T; Kronbach T; Dettmer D
    Cell Signal; 2001 Apr; 13(4):287-97. PubMed ID: 11306246
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mapping the functional domains of human recombinant phosphodiesterase 4A: structural requirements for catalytic activity and rolipram binding.
    Jacobitz S; McLaughlin MM; Livi GP; Burman M; Torphy TJ
    Mol Pharmacol; 1996 Oct; 50(4):891-9. PubMed ID: 8863835
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.
    Huston E; Lumb S; Russell A; Catterall C; Ross AH; Steele MR; Bolger GB; Perry MJ; Owens RJ; Houslay MD
    Biochem J; 1997 Dec; 328 ( Pt 2)(Pt 2):549-58. PubMed ID: 9371714
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family.
    McPhee I; Pooley L; Lobban M; Bolger G; Houslay MD
    Biochem J; 1995 Sep; 310 ( Pt 3)(Pt 3):965-74. PubMed ID: 7575434
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Comparison of recombinant human PDE4 isoforms: interaction with substrate and inhibitors.
    Saldou N; Obernolte R; Huber A; Baecker PA; Wilhelm R; Alvarez R; Li B; Xia L; Callan O; Su C; Jarnagin K; Shelton ER
    Cell Signal; 1998 Jun; 10(6):427-40. PubMed ID: 9720765
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Characterization of CHO-K1 cells stably expressing PDE-IV enzymes. Whole-cell cAMP determinations vs broken-cell enzymatic assays.
    Pon DJ; Plant M; Tkach J; Boulet L; Muise E; Allen RA; Rodger IW
    Cell Biochem Biophys; 1998; 29(1-2):159-78. PubMed ID: 9631244
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of substrate specificity determinants in human cAMP-specific phosphodiesterase 4A by single-point mutagenesis.
    Richter W; Unciuleac L; Hermsdorf T; Kronbach T; Dettmer D
    Cell Signal; 2001 Mar; 13(3):159-67. PubMed ID: 11282454
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The oligomerization state determines regulatory properties and inhibitor sensitivity of type 4 cAMP-specific phosphodiesterases.
    Richter W; Conti M
    J Biol Chem; 2004 Jul; 279(29):30338-48. PubMed ID: 15131123
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Coexpression of human cAMP-specific phosphodiesterase activity and high affinity rolipram binding in yeast.
    Torphy TJ; Stadel JM; Burman M; Cieslinski LB; McLaughlin MM; White JR; Livi GP
    J Biol Chem; 1992 Jan; 267(3):1798-804. PubMed ID: 1309798
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2.
    Sullivan M; Rena G; Begg F; Gordon L; Olsen AS; Houslay MD
    Biochem J; 1998 Aug; 333 ( Pt 3)(Pt 3):693-703. PubMed ID: 9677330
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Association with the SRC family tyrosyl kinase LYN triggers a conformational change in the catalytic region of human cAMP-specific phosphodiesterase HSPDE4A4B. Consequences for rolipram inhibition.
    McPhee I; Yarwood SJ; Scotland G; Huston E; Beard MB; Ross AH; Houslay ES; Houslay MD
    J Biol Chem; 1999 Apr; 274(17):11796-810. PubMed ID: 10206997
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram.
    Shakur Y; Pryde JG; Houslay MD
    Biochem J; 1993 Jun; 292 ( Pt 3)(Pt 3):677-86. PubMed ID: 7686364
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA.
    McLaughlin MM; Cieslinski LB; Burman M; Torphy TJ; Livi GP
    J Biol Chem; 1993 Mar; 268(9):6470-6. PubMed ID: 8384210
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Characterization of the rolipram-sensitive, cyclic AMP-specific phosphodiesterases: identification and differential expression of immunologically distinct forms in the rat brain.
    Iona S; Cuomo M; Bushnik T; Naro F; Sette C; Hess M; Shelton ER; Conti M
    Mol Pharmacol; 1998 Jan; 53(1):23-32. PubMed ID: 9443929
    [TBL] [Abstract][Full Text] [Related]  

  • 17. CDP840: a novel inhibitor of PDE-4.
    Perry MJ; O'Connell J; Walker C; Crabbe T; Baldock D; Russell A; Lumb S; Huang Z; Howat D; Allen R; Merriman M; Walls J; Daniel T; Hughes B; Laliberte F; Higgs GA; Owens RJ
    Cell Biochem Biophys; 1998; 29(1-2):113-32. PubMed ID: 9631241
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene.
    Johnston LA; Erdogan S; Cheung YF; Sullivan M; Barber R; Lynch MJ; Baillie GS; Van Heeke G; Adams DR; Huston E; Houslay MD
    Biochem J; 2004 Jun; 380(Pt 2):371-84. PubMed ID: 15025561
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram.
    Huston E; Pooley L; Julien P; Scotland G; McPhee I; Sullivan M; Bolger G; Houslay MD
    J Biol Chem; 1996 Dec; 271(49):31334-44. PubMed ID: 8940140
    [TBL] [Abstract][Full Text] [Related]  

  • 20. cAMP-specific phosphodiesterase HSPDE4D3 mutants which mimic activation and changes in rolipram inhibition triggered by protein kinase A phosphorylation of Ser-54: generation of a molecular model.
    Hoffmann R; Wilkinson IR; McCallum JF; Engels P; Houslay MD
    Biochem J; 1998 Jul; 333 ( Pt 1)(Pt 1):139-49. PubMed ID: 9639573
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.