These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

162 related articles for article (PubMed ID: 9341205)

  • 1. New inhibitors of thrombin and other trypsin-like proteases: hydrogen bonding of an aromatic cyano group with a backbone amide of the P1 binding site replaces binding of a basic side chain.
    Lee SL; Alexander RS; Smallwood A; Trievel R; Mersinger L; Weber PC; Kettner C
    Biochemistry; 1997 Oct; 36(43):13180-6. PubMed ID: 9341205
    [TBL] [Abstract][Full Text] [Related]  

  • 2. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
    Costanzo MJ; Almond HR; Hecker LR; Schott MR; Yabut SC; Zhang HC; Andrade-Gordon P; Corcoran TW; Giardino EC; Kauffman JA; Lewis JM; de Garavilla L; Haertlein BJ; Maryanoff BE
    J Med Chem; 2005 Mar; 48(6):1984-2008. PubMed ID: 15771442
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-based understanding of ligand affinity using human thrombin as a model system.
    Nienaber VL; Mersinger LJ; Kettner CA
    Biochemistry; 1996 Jul; 35(30):9690-9. PubMed ID: 8703940
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Urethanyl-3-amidinophenylalanine derivatives as inhibitors of factor Xa. X-ray crystal structure of a trypsin/inhibitor complex and modeling studies.
    Sperl S; Bergner A; Stürzebecher J; Magdolen V; Bode W; Moroder L
    Biol Chem; 2000 Apr; 381(4):321-9. PubMed ID: 10839461
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
    Katz BA; Elrod K; Luong C; Rice MJ; Mackman RL; Sprengeler PA; Spencer J; Hataye J; Janc J; Link J; Litvak J; Rai R; Rice K; Sideris S; Verner E; Young W
    J Mol Biol; 2001 Apr; 307(5):1451-86. PubMed ID: 11292354
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Molecular design and characterization of an alpha-thrombin inhibitor containing a novel P1 moiety.
    Malikayil JA; Burkhart JP; Schreuder HA; Broersma RJ; Tardif C; Kutcher LW; Mehdi S; Schatzman GL; Neises B; Peet NP
    Biochemistry; 1997 Feb; 36(5):1034-40. PubMed ID: 9033393
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Selection of S18326 as a new potent and selective boronic acid direct thrombin inhibitor.
    Rupin A; Mennecier P; Lila C; de Nanteuil G; Verbeuren TJ
    Thromb Haemost; 1997 Oct; 78(4):1221-7. PubMed ID: 9364988
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Peptidyl beta-homo-aspartals (3-amino-4-carboxybutyraldehydes): new specific inhibitors of caspases.
    Bajusz S; Fauszt I; Németh K; Barabás E; Juhász A; Patthy M; Bauer PI
    Biopolymers; 1999; 51(1):109-18. PubMed ID: 10380358
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures.
    Slon-Usakiewicz JJ; Sivaraman J; Li Y; Cygler M; Konishi Y
    Biochemistry; 2000 Mar; 39(9):2384-91. PubMed ID: 10694407
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes.
    Krishnan R; Zhang E; Hakansson K; Arni RK; Tulinsky A; Lim-Wilby MS; Levy OE; Semple JE; Brunck TK
    Biochemistry; 1998 Sep; 37(35):12094-103. PubMed ID: 9724521
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The crystal structures of human alpha-thrombin complexed with active site-directed diamino benzo[b]thiophene derivatives: a binding mode for a structurally novel class of inhibitors.
    Chirgadze NY; Sall DJ; Briggs SL; Clawson DK; Zhang M; Smith GF; Schevitz RW
    Protein Sci; 2000 Jan; 9(1):29-36. PubMed ID: 10739244
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Kinetic properties of the binding of alpha-lytic protease to peptide boronic acids.
    Kettner CA; Bone R; Agard DA; Bachovchin WW
    Biochemistry; 1988 Oct; 27(20):7682-8. PubMed ID: 3207699
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Novel non-covalent azaphenylalanine thrombin inhibitors with an aminomethyl or amino group at the P1 position.
    Obreza A; Stegnar M; Urleb U
    Pharmazie; 2004 Sep; 59(9):659-67. PubMed ID: 15497744
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The selective inhibition of thrombin by peptides of boroarginine.
    Kettner C; Mersinger L; Knabb R
    J Biol Chem; 1990 Oct; 265(30):18289-97. PubMed ID: 2211702
    [TBL] [Abstract][Full Text] [Related]  

  • 15. High-resolution structures of three new trypsin-squash-inhibitor complexes: a detailed comparison with other trypsins and their complexes.
    Helland R; Berglund GI; Otlewski J; Apostoluk W; Andersen OA; Willassen NP; Smalås AO
    Acta Crystallogr D Biol Crystallogr; 1999 Jan; 55(Pt 1):139-48. PubMed ID: 10089404
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The methyl group of N(alpha)(Me)Arg-containing peptides disturbs the active-site geometry of thrombin, impairing efficient cleavage.
    Friedrich R; Steinmetzer T; Huber R; Stürzebecher J; Bode W
    J Mol Biol; 2002 Mar; 316(4):869-74. PubMed ID: 11884127
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The 2.2 A crystal structure of human chymase in complex with succinyl-Ala-Ala-Pro-Phe-chloromethylketone: structural explanation for its dipeptidyl carboxypeptidase specificity.
    Pereira PJ; Wang ZM; Rubin H; Huber R; Bode W; Schechter NM; Strobl S
    J Mol Biol; 1999 Feb; 286(1):163-73. PubMed ID: 9931257
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide.
    Skordalakes E; Elgendy S; Goodwin CA; Green D; Scully MF; Kakkar VV; Freyssinet JM; Dodson G; Deadman JJ
    Biochemistry; 1998 Oct; 37(41):14420-7. PubMed ID: 9772168
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Novel non-covalent thrombin inhibitors incorporating P(1) 4,5,6,7-tetrahydrobenzothiazole arginine side chain mimetics.
    Marinko P; Krbavcic A; Mlinsek G; Solmajer T; Bakija AT; Stegnar M; Stojan J; Kikelj D
    Eur J Med Chem; 2004 Mar; 39(3):257-65. PubMed ID: 15051174
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition.
    Dullweber F; Stubbs MT; Musil D; Stürzebecher J; Klebe G
    J Mol Biol; 2001 Oct; 313(3):593-614. PubMed ID: 11676542
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.