240 related articles for article (PubMed ID: 9379353)
1. Relationships between the hepatic intrinsic clearance or blood cell-plasma partition coefficient in the rabbit and the lipophilicity of basic drugs.
Ishizaki J; Yokogawa K; Nakashima E; Ichimura F
J Pharm Pharmacol; 1997 Aug; 49(8):768-72. PubMed ID: 9379353
[TBL] [Abstract][Full Text] [Related]
2. Prediction of changes in the clinical pharmacokinetics of basic drugs on the basis of octanol-water partition coefficients.
Ishizaki J; Yokogawa K; Nakashima E; Ichimura F
J Pharm Pharmacol; 1997 Aug; 49(8):762-7. PubMed ID: 9379352
[TBL] [Abstract][Full Text] [Related]
3. Relationships in the structure-tissue distribution of basic drugs in the rabbit.
Yokogawa K; Nakashima E; Ishizaki J; Maeda H; Nagano T; Ichimura F
Pharm Res; 1990 Jul; 7(7):691-6. PubMed ID: 2395795
[TBL] [Abstract][Full Text] [Related]
4. Lipophilic and electrostatic forces encoded in IAM-HPLC indexes of basic drugs: their role in membrane partition and their relationships with BBB passage data.
Grumetto L; Carpentiero C; Barbato F
Eur J Pharm Sci; 2012 Apr; 45(5):685-92. PubMed ID: 22306648
[TBL] [Abstract][Full Text] [Related]
5.
Li X; Jusko WJ
Drug Metab Dispos; 2022 Oct; ():. PubMed ID: 36195337
[TBL] [Abstract][Full Text] [Related]
6. A Machine Learning Framework to Improve Rat Clearance Predictions and Inform Physiologically Based Pharmacokinetic Modeling.
Andrews-Morger A; Reutlinger M; Parrott N; Olivares-Morales A
Mol Pharm; 2023 Oct; 20(10):5052-5065. PubMed ID: 37713584
[TBL] [Abstract][Full Text] [Related]
7. Rapid method for the estimation of octanol/water partition coefficient (log P(oct)) from gradient RP-HPLC retention and a hydrogen bond acidity term (zetaalpha(2)(H)).
Valko K; My Du C; Bevan C; Reynolds DP; Abraham MH
Curr Med Chem; 2001 Jul; 8(9):1137-46. PubMed ID: 11472245
[TBL] [Abstract][Full Text] [Related]
8. Prediction of adipose tissue: plasma partition coefficients for structurally unrelated drugs.
Poulin P; Schoenlein K; Theil FP
J Pharm Sci; 2001 Apr; 90(4):436-47. PubMed ID: 11170034
[TBL] [Abstract][Full Text] [Related]
9. A priori prediction of tissue:plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery.
Poulin P; Theil FP
J Pharm Sci; 2000 Jan; 89(1):16-35. PubMed ID: 10664535
[TBL] [Abstract][Full Text] [Related]
10. Direct Comparison of Total Clearance Prediction: Computational Machine Learning Model versus Bottom-Up Approach Using In Vitro Assay.
Kosugi Y; Hosea N
Mol Pharm; 2020 Jul; 17(7):2299-2309. PubMed ID: 32478525
[TBL] [Abstract][Full Text] [Related]
11. Influence of lipophilicity and lysosomal accumulation on tissue distribution kinetics of basic drugs: a physiologically based pharmacokinetic model.
Yokogawa K; Ishizaki J; Ohkuma S; Miyamoto K
Methods Find Exp Clin Pharmacol; 2002 Mar; 24(2):81-93. PubMed ID: 12040887
[TBL] [Abstract][Full Text] [Related]
12. Relationship between polysorbate 80 solubilization descriptors and octanol-water partition coefficients of drugs.
Alvarez-Núñez FA; Yalkowsky SH
Int J Pharm; 2000 May; 200(2):217-22. PubMed ID: 10867251
[TBL] [Abstract][Full Text] [Related]
13. Modulation of the partition coefficient between octanol and buffer at pH 7.4 and pKa to achieve the optimum balance of blood clearance and volume of distribution for a series of tetrahydropyran histamine type 3 receptor antagonists.
Hay T; Jones R; Beaumont K; Kemp M
Drug Metab Dispos; 2009 Sep; 37(9):1864-70. PubMed ID: 19546239
[TBL] [Abstract][Full Text] [Related]
14. Lipophilic and polar interaction forces between acidic drugs and membrane phospholipids encoded in IAM-HPLC indexes: their role in membrane partition and relationships with BBB permeation data.
Grumetto L; Carpentiero C; Di Vaio P; Frecentese F; Barbato F
J Pharm Biomed Anal; 2013 Mar; 75():165-72. PubMed ID: 23261809
[TBL] [Abstract][Full Text] [Related]
15. Estimation of the ethanol/water solubility profile from the octanol/water partition coefficient.
Machatha SG; Yalkowsky SH
Int J Pharm; 2004 Nov; 286(1-2):111-5. PubMed ID: 15501007
[TBL] [Abstract][Full Text] [Related]
16. Intrinsic Clearance Assay Incubational Binding: A Method Comparison.
Chen S; Prieto Garcia L; Bergström F; Nordell P; Grime K
Drug Metab Dispos; 2017 Apr; 45(4):342-345. PubMed ID: 28122786
[TBL] [Abstract][Full Text] [Related]
17. Recent methodologies for the estimation of n-octanol/water partition coefficients and their use in the prediction of membrane transport properties of drugs.
Klopman G; Zhu H
Mini Rev Med Chem; 2005 Feb; 5(2):127-33. PubMed ID: 15720283
[TBL] [Abstract][Full Text] [Related]
18. Partition and distribution coefficients of solutes and drugs in brush border membrane vesicles.
Alcorn CJ; Simpson RJ; Leahy DE; Peters TJ
Biochem Pharmacol; 1993 May; 45(9):1775-82. PubMed ID: 8494536
[TBL] [Abstract][Full Text] [Related]
19. Determination of conformer-specific partition coefficients in octanol/water systems.
Kraszni M; Bányai I; Noszál B
J Med Chem; 2003 May; 46(11):2241-5. PubMed ID: 12747795
[TBL] [Abstract][Full Text] [Related]
20. Electrochemical determination of partition coefficients of drugs.
Kontturi K; Murtomäki L
J Pharm Sci; 1992 Oct; 81(10):970-5. PubMed ID: 1432622
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
