194 related articles for article (PubMed ID: 9415318)
1. Varicella-zoster virus thymidine kinase gene and antiherpetic pyrimidine nucleoside analogues in a combined gene/chemotherapy treatment for cancer.
Degrève B; Andrei G; Izquierdo M; Piette J; Morin K; Knaus EE; Wiebe LI; Basrah I; Walker RT; De Clercq E; Balzarini J
Gene Ther; 1997 Oct; 4(10):1107-14. PubMed ID: 9415318
[TBL] [Abstract][Full Text] [Related]
2. Comparative cytostatic activity of different antiherpetic drugs against herpes simplex virus thymidine kinase gene-transfected tumor cells.
Balzarini J; Bohman C; Walker RT; de Clercq E
Mol Pharmacol; 1994 Jun; 45(6):1253-8. PubMed ID: 8022417
[TBL] [Abstract][Full Text] [Related]
3. Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase.
Grignet-Debrus C; Cool V; Baudson N; Degrève B; Balzarini J; De Leval L; Debrus S; Velu T; Calberg-Bacq CM
Cancer Gene Ther; 2000 Feb; 7(2):215-23. PubMed ID: 10770629
[TBL] [Abstract][Full Text] [Related]
4. Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene.
Balzarini J; De Clercq E; Verbruggen A; Ayusawa D; Shimizu K; Seno T
Mol Pharmacol; 1987 Sep; 32(3):410-6. PubMed ID: 2823092
[TBL] [Abstract][Full Text] [Related]
5. Novel (E)-5-(2-iodovinyl)-2'-deoxyuridine derivatives as potential cytostatic agents against herpes simplex virus thymidine kinase gene transfected tumors.
Balzarini J; Morin KW; Knaus EE; Wiebe LI; De Clercq E
Gene Ther; 1995 Jul; 2(5):317-22. PubMed ID: 7671107
[TBL] [Abstract][Full Text] [Related]
6. Highly selective cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine derivatives for murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 thymidine kinase gene.
Balzarini J; De Clercq E; Verbruggen A; Ayusawa D; Seno T
Mol Pharmacol; 1985 Dec; 28(6):581-7. PubMed ID: 3001499
[TBL] [Abstract][Full Text] [Related]
7. Bystander effect of purine nucleoside analogues in HSV-1 tk suicide gene therapy is superior to that of pyrimidine nucleoside analogues.
Degrève B; De Clercq E; Balzarini J
Gene Ther; 1999 Feb; 6(2):162-70. PubMed ID: 10435100
[TBL] [Abstract][Full Text] [Related]
8. Selection of HSV-1 TK gene-transfected murine mammary carcinoma cells resistant to (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and ganciclovir (GCV).
Degrève B; De Clercq E; Balzarini J
Gene Ther; 2000 Sep; 7(18):1543-52. PubMed ID: 11021592
[TBL] [Abstract][Full Text] [Related]
9. Increased sensitivity of thymidine kinase-deficient (TK-) tumor cell lines to the cell growth inhibitory effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and related compounds.
Balzarini J; De Clercq E; Verbruggen A; Crumpacker C; Ayusawa D; Seno T
Anticancer Res; 1986; 6(5):1077-84. PubMed ID: 2432829
[TBL] [Abstract][Full Text] [Related]
10. Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells.
Balzarini J; Degrève B; Andrei G; Neyts J; Sandvold M; Myhren F; de Clercq E
Gene Ther; 1998 Mar; 5(3):419-26. PubMed ID: 9614564
[TBL] [Abstract][Full Text] [Related]
11. 5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.
Cristofoli WA; Wiebe LI; De Clercq E; Andrei G; Snoeck R; Balzarini J; Knaus EE
J Med Chem; 2007 Jun; 50(12):2851-7. PubMed ID: 17518459
[TBL] [Abstract][Full Text] [Related]
12. The role of cellular- and prodrug-associated factors in the bystander effect induced by the Varicella zoster and Herpes simplex viral thymidine kinases in suicide gene therapy.
Grignet-Debrus C; Cool V; Baudson N; Velu T; Calberg-Bacq CM
Cancer Gene Ther; 2000 Nov; 7(11):1456-68. PubMed ID: 11129288
[TBL] [Abstract][Full Text] [Related]
13. Potential of Varicella zoster virus thymidine kinase as a suicide gene in breast cancer cells.
Grignet-Debrus C; Calberg-Bacq CM
Gene Ther; 1997 Jun; 4(6):560-9. PubMed ID: 9231072
[TBL] [Abstract][Full Text] [Related]
14. Mutations distal to the substrate site can affect varicella zoster virus thymidine kinase activity: implications for drug design.
El Omari K; Liekens S; Bird LE; Balzarini J; Stammers DK
Mol Pharmacol; 2006 Jun; 69(6):1891-6. PubMed ID: 16556772
[TBL] [Abstract][Full Text] [Related]
15. (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU).
De Clercq E
Med Res Rev; 2005 Jan; 25(1):1-20. PubMed ID: 15389733
[TBL] [Abstract][Full Text] [Related]
16. Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
Russ P; Schelling P; Scapozza L; Folkers G; Clercq ED; Marquez VE
J Med Chem; 2003 Nov; 46(23):5045-54. PubMed ID: 14584954
[TBL] [Abstract][Full Text] [Related]
17. Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2.
Balzarini J; Bohman C; De Clercq E
J Biol Chem; 1993 Mar; 268(9):6332-7. PubMed ID: 8384209
[TBL] [Abstract][Full Text] [Related]
18. Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase.
Degrève B; Esnouf R; De Clercq E; Balzarini J
Mol Pharmacol; 2001 Feb; 59(2):285-93. PubMed ID: 11160865
[TBL] [Abstract][Full Text] [Related]
19. Comparative inhibition of DNA polymerases from varicella zoster virus (TK+ and TK-) strains by (E)-5-(2-bromovinyl)-2'-deoxyuridine 5'-triphosphate.
Yokota T; Konno K; Shigeta S; De Clercq E
Mol Pharmacol; 1984 Sep; 26(2):376-80. PubMed ID: 6090888
[TBL] [Abstract][Full Text] [Related]
20. (E)-5-(2-bromovinyl)-2'-deoxyuridine potentiates ganciclovir-mediated cytotoxicity on herpes simplex virus-thymidine kinase--expressing cells.
Hamel W; Zirkel D; Mehdorn HM; Westphal M; Israel MA
Cancer Gene Ther; 2001 May; 8(5):388-96. PubMed ID: 11477459
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
