These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

118 related articles for article (PubMed ID: 9421679)

  • 1. Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices.
    Houston JB; Carlile DJ
    Drug Metab Rev; 1997 Nov; 29(4):891-922. PubMed ID: 9421679
    [No Abstract]   [Full Text] [Related]  

  • 2. Kinetics of drug metabolism in rat liver slices: IV. Comparison of ethoxycoumarin clearance by liver slices, isolated hepatocytes, and hepatic microsomes from rats pretreated with known modifiers of cytochrome P-450 activity.
    Carlile DJ; Hakooz N; Houston JB
    Drug Metab Dispos; 1999 Apr; 27(4):526-32. PubMed ID: 10101148
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance.
    Fagerholm U
    J Pharm Pharmacol; 2007 Jun; 59(6):803-28. PubMed ID: 17637173
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Prediction of the hepatic and renal clearance of transporter substrates in rats using in vitro uptake experiments.
    Watanabe T; Maeda K; Kondo T; Nakayama H; Horita S; Kusuhara H; Sugiyama Y
    Drug Metab Dispos; 2009 Jul; 37(7):1471-9. PubMed ID: 19364828
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Prediction of human pharmacokinetics from preclinical information: comparative accuracy of quantitative prediction approaches.
    Hosea NA; Collard WT; Cole S; Maurer TS; Fang RX; Jones H; Kakar SM; Nakai Y; Smith BJ; Webster R; Beaumont K
    J Clin Pharmacol; 2009 May; 49(5):513-33. PubMed ID: 19299532
    [TBL] [Abstract][Full Text] [Related]  

  • 6. [Advances and related issues in the use of in vitro methods to predict metabolic clearance rate of new drugs].
    Zhang Q; Wang GJ
    Yao Xue Xue Bao; 2007 Oct; 42(10):1023-8. PubMed ID: 18229605
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Metabolite kinetics of ondansetron in rat. Comparison of hepatic microsomes, isolated hepatocytes and liver slices, with in vivo disposition.
    Worboys PD; Brennan B; Bradbury A; Houston JB
    Xenobiotica; 1996 Sep; 26(9):897-907. PubMed ID: 8893037
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes.
    Riley RJ; McGinnity DF; Austin RP
    Drug Metab Dispos; 2005 Sep; 33(9):1304-11. PubMed ID: 15932954
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: studies of digoxin metabolism in primary rat hepatocytes versus microsomes.
    Lam JL; Benet LZ
    Drug Metab Dispos; 2004 Nov; 32(11):1311-6. PubMed ID: 15483198
    [TBL] [Abstract][Full Text] [Related]  

  • 10. In vivo disposition of caffeine predicted from hepatic microsomal and hepatocyte data.
    Hayes KA; Brennan B; Chenery R; Houston JB
    Drug Metab Dispos; 1995 Mar; 23(3):349-53. PubMed ID: 7628300
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Prediction of human pharmacokinetics--improving microsome-based predictions of hepatic metabolic clearance.
    Fagerholm U
    J Pharm Pharmacol; 2007 Oct; 59(10):1427-31. PubMed ID: 17910819
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Sigmoidal kinetics of CYP3A substrates: an approach for scaling dextromethorphan metabolism in hepatic microsomes and isolated hepatocytes to predict in vivo clearance in rat.
    Witherow LE; Houston JB
    J Pharmacol Exp Ther; 1999 Jul; 290(1):58-65. PubMed ID: 10381760
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans.
    Naritomi Y; Terashita S; Kimura S; Suzuki A; Kagayama A; Sugiyama Y
    Drug Metab Dispos; 2001 Oct; 29(10):1316-24. PubMed ID: 11560875
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance.
    Brown HS; Griffin M; Houston JB
    Drug Metab Dispos; 2007 Feb; 35(2):293-301. PubMed ID: 17132764
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Pharmacokinetics and metabolism of a cysteinyl leukotriene-1 receptor antagonist from the heterocyclic chromanol series in rats: in vitro-in vivo correlation, gender-related differences, isoform identification, and comparison with metabolism in human hepatic tissue.
    Kuperman AV; Kalgutkar AS; Marfat A; Chambers RJ; Liston TE
    Drug Metab Dispos; 2001 Nov; 29(11):1403-9. PubMed ID: 11602515
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Kinetic determinants of hepatic clearance: plasma protein binding and hepatic uptake.
    Baker M; Parton T
    Xenobiotica; 2007; 37(10-11):1110-34. PubMed ID: 17968739
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Analysis of hepatic metabolism affecting pharmacokinetics of propranolol in humans.
    Kiriyama A; Honbo A; Iga K
    Int J Pharm; 2008 Feb; 349(1-2):53-60. PubMed ID: 17765415
    [TBL] [Abstract][Full Text] [Related]  

  • 18. First-principle, structure-based prediction of hepatic metabolic clearance values in human.
    Li H; Sun J; Sui X; Liu J; Yan Z; Liu X; Sun Y; He Z
    Eur J Med Chem; 2009 Apr; 44(4):1600-6. PubMed ID: 18768239
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The biotransformation of the ergot derivative CQA 206-291 in human, dog, and rat liver slice cultures and prediction of in vivo plasma clearance.
    Vickers AE; Connors S; Zollinger M; Biggi WA; Larrauri A; Vogelaar JP; Brendel K
    Drug Metab Dispos; 1993; 21(3):454-9. PubMed ID: 8100501
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Kinetics of drug metabolism in rat liver slices. III. Relationship between metabolic clearance and slice uptake rate.
    Worboys PD; Bradbury A; Houston JB
    Drug Metab Dispos; 1997 Apr; 25(4):460-7. PubMed ID: 9107546
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.