194 related articles for article (PubMed ID: 9434286)
1. Acyloxymethyl as a drug protecting group: Part 4. The hydrolysis of tertiary amidomethyl ester prodrugs of carboxylic acid agents.
Iley J; Moreira R; Calheiros T; Mendes E
Pharm Res; 1997 Nov; 14(11):1634-9. PubMed ID: 9434286
[TBL] [Abstract][Full Text] [Related]
2. Cleavage of tertiary amidomethyl ester prodrugs of carboxylic acids by rat liver homogenates.
Iley J; Mendes E; Moreira R; Souza S
Eur J Pharm Sci; 1999 Dec; 9(2):201-5. PubMed ID: 10620732
[TBL] [Abstract][Full Text] [Related]
3. Acyloxymethyl as a drug protecting group. Part 3. Tertiary O-amidomethyl esters of penicillin G: chemical hydrolysis and anti-bacterial activity.
Moreira R; Calheiros T; Cabrita J; Mendes E; Pimentel M; Iley J
Pharm Res; 1996 Jan; 13(1):70-5. PubMed ID: 8668682
[TBL] [Abstract][Full Text] [Related]
4. Acyloxymethyl as a drug protecting group. Part 7: Tertiary sulfonamidomethyl ester prodrugs of benzylpenicillin: chemical hydrolysis and anti-bacterial activity.
Iley J; Barroso H; Moreira R; Lopes F; Calheiros T
Bioorg Med Chem; 2000 Jul; 8(7):1629-36. PubMed ID: 10976510
[TBL] [Abstract][Full Text] [Related]
5. Pharmacokinetic studies of naproxen amides of some amino acid esters with promising colorectal cancer chemopreventive activity.
Aboul-Fadl T; Al-Hamad SS; Fouad EA
Bioorg Chem; 2018 Feb; 76():370-379. PubMed ID: 29241109
[TBL] [Abstract][Full Text] [Related]
6. Aminocarbonyloxymethyl ester prodrugs of flufenamic acid and diclofenac: suppressing the rearrangement pathway in aqueous media.
Ribeiro L; Silva N; Iley J; Rautio J; Järvinen T; Mota-Filipe H; Moreira R; Mendes E
Arch Pharm (Weinheim); 2007 Jan; 340(1):32-40. PubMed ID: 17206608
[TBL] [Abstract][Full Text] [Related]
7. Glycolamide esters as biolabile prodrugs of carboxylic acid agents: synthesis, stability, bioconversion, and physicochemical properties.
Nielsen NM; Bundgaard H
J Pharm Sci; 1988 Apr; 77(4):285-98. PubMed ID: 3379586
[TBL] [Abstract][Full Text] [Related]
8. Synthesis, stability and in vitro dermal evaluation of aminocarbonyloxymethyl esters as prodrugs of carboxylic acid agents.
Mendes E; Furtado T; Neres J; Iley J; Jarvinen T; Rautio J; Moreira R
Bioorg Med Chem; 2002 Mar; 10(3):809-16. PubMed ID: 11814870
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and in vitro investigations of nalidixic acid amides of amino acid esters as prodrugs.
Aboul-Fadl T; Fouad EA
Pharmazie; 1996 Jan; 51(1):30-3. PubMed ID: 8999431
[TBL] [Abstract][Full Text] [Related]
10. Bioreversible derivatives of phenol. 2. Reactivity of carbonate esters with fatty acid-like structures towards hydrolysis in aqueous solutions.
Østergaard J; Larsen C
Molecules; 2007 Oct; 12(10):2396-412. PubMed ID: 17978765
[TBL] [Abstract][Full Text] [Related]
11. Prodrugs of vitamin E. 1. Preparation and enzymatic hydrolysis of aminoalkanecarboxylic acid esters of d-alpha-tocopherol.
Takata J; Karube Y; Nagata Y; Matsushima Y
J Pharm Sci; 1995 Jan; 84(1):96-100. PubMed ID: 7714753
[TBL] [Abstract][Full Text] [Related]
12. Synthesis, chemical and enzymatic hydrolysis, and bioavailability evaluation in rabbits of metronidazole amino acid ester prodrugs with enhanced water solubility.
Mahfouz NM; Hassan MA
J Pharm Pharmacol; 2001 Jun; 53(6):841-8. PubMed ID: 11428660
[TBL] [Abstract][Full Text] [Related]
13. Chlorzoxazone esters of some non-steroidal anti-inflammatory (NSAI) carboxylic acids as mutual prodrugs: design, synthesis, pharmacological investigations and docking studies.
Abdel-Azeem AZ; Abdel-Hafez AA; El-Karamany GS; Farag HH
Bioorg Med Chem; 2009 May; 17(10):3665-70. PubMed ID: 19398345
[TBL] [Abstract][Full Text] [Related]
14. Triazene drug metabolites. Part 17: Synthesis and plasma hydrolysis of acyloxymethyl carbamate derivatives of antitumour triazenes.
Carvalho E; Francisco AP; Iley J; Rosa E
Bioorg Med Chem; 2000 Jul; 8(7):1719-25. PubMed ID: 10976519
[TBL] [Abstract][Full Text] [Related]
15. Chemical and enzymatic stability of amino acid prodrugs containing methoxy, ethoxy and propylene glycol linkers.
Gupta D; Gupta SV; Lee KD; Amidon GL
Mol Pharm; 2009; 6(5):1604-11. PubMed ID: 19566080
[TBL] [Abstract][Full Text] [Related]
16. Acyloxymethyl as a drug protecting group. Part 6: N-acyloxymethyl- and N-[(aminocarbonyloxy)methyl]sulfonamides as prodrugs of agents containing a secondary sulfonamide group.
Lopes F; Moreira R; Iley J
Bioorg Med Chem; 2000 Apr; 8(4):707-16. PubMed ID: 10819159
[TBL] [Abstract][Full Text] [Related]
17. Capture hydrolysis signals in the microsomal stability assay: molecular mechanisms of the alkyl ester drug and prodrug metabolism.
Sun H
Bioorg Med Chem Lett; 2012 Jan; 22(2):989-95. PubMed ID: 22197392
[TBL] [Abstract][Full Text] [Related]
18. The hydrolysis kinetics of monobasic and dibasic aminoalkyl esters of ketorolac.
Qandil AM; Jamhawi NM; Tashtoush BM; Al-Ajlouni AM; Idkaidek NM; Obaidat AA
Drug Dev Ind Pharm; 2013 Sep; 39(9):1346-56. PubMed ID: 22995063
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and Biological Evaluation of Mutual Prodrugs of Carboxylic Group Containing Some Non-Steroidal Anti-Inflammatory Drugs and Propyphenazone.
Paliwal M; Sucheta ; Ruchita ; Jain S; Monika ; Himanshu
Curr Drug Deliv; 2017; 14(8):1213-1224. PubMed ID: 28201966
[TBL] [Abstract][Full Text] [Related]
20. Specificity of a prodrug-activating enzyme hVACVase: the leaving group effect.
Sun J; Dahan A; Walls ZF; Lai L; Lee KD; Amidon GL
Mol Pharm; 2010 Dec; 7(6):2362-8. PubMed ID: 21028903
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]