545 related articles for article (PubMed ID: 9434860)
1. Oxidative damage in chemical teratogenesis.
Wells PG; Kim PM; Laposa RR; Nicol CJ; Parman T; Winn LM
Mutat Res; 1997 Dec; 396(1-2):65-78. PubMed ID: 9434860
[TBL] [Abstract][Full Text] [Related]
2. DNA oxidation as a potential molecular mechanism mediating drug-induced birth defects: phenytoin and structurally related teratogens initiate the formation of 8-hydroxy-2'-deoxyguanosine in vitro and in vivo in murine maternal hepatic and embryonic tissues.
Liu L; Wells PG
Free Radic Biol Med; 1995 Nov; 19(5):639-48. PubMed ID: 8529923
[TBL] [Abstract][Full Text] [Related]
3. Evidence for embryonic prostaglandin H synthase-catalyzed bioactivation and reactive oxygen species-mediated oxidation of cellular macromolecules in phenytoin and benzo[a]pyrene teratogenesis.
Winn LM; Wells PG
Free Radic Biol Med; 1997; 22(4):607-21. PubMed ID: 9013124
[TBL] [Abstract][Full Text] [Related]
4. Molecular and biochemical mechanisms in teratogenesis involving reactive oxygen species.
Wells PG; Bhuller Y; Chen CS; Jeng W; Kasapinovic S; Kennedy JC; Kim PM; Laposa RR; McCallum GP; Nicol CJ; Parman T; Wiley MJ; Wong AW
Toxicol Appl Pharmacol; 2005 Sep; 207(2 Suppl):354-66. PubMed ID: 16081118
[TBL] [Abstract][Full Text] [Related]
5. In vivo phenytoin-initiated oxidative damage to proteins and lipids in murine maternal hepatic and embryonic tissue organelles: potential molecular targets of chemical teratogenesis.
Liu L; Wells PG
Toxicol Appl Pharmacol; 1994 Apr; 125(2):247-55. PubMed ID: 8171432
[TBL] [Abstract][Full Text] [Related]
6. Potential molecular targets mediating chemical teratogenesis: in vitro peroxidase-catalyzed phenytoin metabolism and oxidative damage to proteins and lipids in murine maternal hepatic microsomes and embryonic 9000g supernatant.
Liu L; Wells PG
Toxicol Appl Pharmacol; 1995 Sep; 134(1):71-80. PubMed ID: 7676459
[TBL] [Abstract][Full Text] [Related]
7. Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity.
Parman T; Wiley MJ; Wells PG
Nat Med; 1999 May; 5(5):582-5. PubMed ID: 10229238
[TBL] [Abstract][Full Text] [Related]
8. UDP-glucuronosyltransferase-mediated protection against in vitro DNA oxidation and micronucleus formation initiated by phenytoin and its embryotoxic metabolite 5-(p-hydroxyphenyl)-5-phenylhydantoin.
Kim PM; Winn LM; Parman T; Wells PG
J Pharmacol Exp Ther; 1997 Jan; 280(1):200-9. PubMed ID: 8996197
[TBL] [Abstract][Full Text] [Related]
9. Biochemical toxicology of chemical teratogenesis.
Wells PG; Winn LM
Crit Rev Biochem Mol Biol; 1996 Feb; 31(1):1-40. PubMed ID: 8744954
[TBL] [Abstract][Full Text] [Related]
10. Oxidative stress in developmental origins of disease: teratogenesis, neurodevelopmental deficits, and cancer.
Wells PG; McCallum GP; Chen CS; Henderson JT; Lee CJ; Perstin J; Preston TJ; Wiley MJ; Wong AW
Toxicol Sci; 2009 Mar; 108(1):4-18. PubMed ID: 19126598
[TBL] [Abstract][Full Text] [Related]
11. Oxidative DNA damage and repair in teratogenesis and neurodevelopmental deficits.
Wells PG; McCallum GP; Lam KC; Henderson JT; Ondovcik SL
Birth Defects Res C Embryo Today; 2010 Jun; 90(2):103-9. PubMed ID: 20544694
[TBL] [Abstract][Full Text] [Related]
12. Phenytoin-initiated DNA oxidation in murine embryo culture, and embryo protection by the antioxidative enzymes superoxide dismutase and catalase: evidence for reactive oxygen species-mediated DNA oxidation in the molecular mechanism of phenytoin teratogenicity.
Winn LM; Wells PG
Mol Pharmacol; 1995 Jul; 48(1):112-20. PubMed ID: 7623765
[TBL] [Abstract][Full Text] [Related]
13. Genoprotection by UDP-glucuronosyltransferases in peroxidase-dependent, reactive oxygen species-mediated micronucleus initiation by the carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene.
Kim PM; Wells PG
Cancer Res; 1996 Apr; 56(7):1526-32. PubMed ID: 8603397
[TBL] [Abstract][Full Text] [Related]
14. Embryopathic effects of thalidomide and its hydrolysis products in rabbit embryo culture: evidence for a prostaglandin H synthase (PHS)-dependent, reactive oxygen species (ROS)-mediated mechanism.
Lee CJ; Gonçalves LL; Wells PG
FASEB J; 2011 Jul; 25(7):2468-83. PubMed ID: 21502285
[TBL] [Abstract][Full Text] [Related]
15. Maternal administration of superoxide dismutase and catalase in phenytoin teratogenicity.
Winn LM; Wells PG
Free Radic Biol Med; 1999 Feb; 26(3-4):266-74. PubMed ID: 9895216
[TBL] [Abstract][Full Text] [Related]
16. Free radical intermediates of phenytoin and related teratogens. Prostaglandin H synthase-catalyzed bioactivation, electron paramagnetic resonance spectrometry, and photochemical product analysis.
Parman T; Chen G; Wells PG
J Biol Chem; 1998 Sep; 273(39):25079-88. PubMed ID: 9737965
[TBL] [Abstract][Full Text] [Related]
17. Modulation of phenytoin teratogenicity and embryonic covalent binding by acetylsalicylic acid, caffeic acid, and alpha-phenyl-N-t-butylnitrone: implications for bioactivation by prostaglandin synthetase.
Wells PG; Zubovits JT; Wong ST; Molinari LM; Ali S
Toxicol Appl Pharmacol; 1989 Feb; 97(2):192-202. PubMed ID: 2493687
[TBL] [Abstract][Full Text] [Related]
18. Receptor- and reactive intermediate-mediated mechanisms of teratogenesis.
Wells PG; Lee CJ; McCallum GP; Perstin J; Harper PA
Handb Exp Pharmacol; 2010; (196):131-62. PubMed ID: 20020262
[TBL] [Abstract][Full Text] [Related]
19. Phenytoin covalent binding and embryopathy in mouse embryos co-cultured with maternal hepatocytes from mouse, rat, and rabbit.
Ozolins TR; Wiley MJ; Wells PG
Biochem Pharmacol; 1995 Nov; 50(11):1831-40. PubMed ID: 8615862
[TBL] [Abstract][Full Text] [Related]
20. Inhibition of trimethadione and dimethadione teratogenicity by the cyclooxygenase inhibitor acetylsalicylic acid: a unifying hypothesis for the teratologic effects of hydantoin anticonvulsants and structurally related compounds.
Wells PG; Nagai MK; Greco GS
Toxicol Appl Pharmacol; 1989 Mar; 97(3):406-14. PubMed ID: 2609340
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]