BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

988 related articles for article (PubMed ID: 9434879)

  • 1. Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models.
    Kaina B; Ziouta A; Ochs K; Coquerelle T
    Mutat Res; 1997 Nov; 381(2):227-41. PubMed ID: 9434879
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Induction of c-fos, c-jun, junB and junD mRNA and AP-1 by alkylating mutagens in cells deficient and proficient for the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) and its relationship to cell death, mutation induction and chromosomal instability.
    Dosch J; Kaina B
    Oncogene; 1996 Nov; 13(9):1927-35. PubMed ID: 8934539
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: a long road traveled and still a far way to go.
    Kaina B
    Cytogenet Genome Res; 2004; 104(1-4):77-86. PubMed ID: 15162018
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs.
    Roos WP; Nikolova T; Quiros S; Naumann SC; Kiedron O; Zdzienicka MZ; Kaina B
    DNA Repair (Amst); 2009 Jan; 8(1):72-86. PubMed ID: 18840549
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Transfection and expression of human O6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents.
    Kaina B; Fritz G; Mitra S; Coquerelle T
    Carcinogenesis; 1991 Oct; 12(10):1857-67. PubMed ID: 1657427
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Contribution of O6-alkylguanine and N-alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: new insights gained from studies of genetically engineered mammalian cell lines.
    Kaina B; Fritz G; Coquerelle T
    Environ Mol Mutagen; 1993; 22(4):283-92. PubMed ID: 8223512
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Processing of O6-methylguanine into DNA double-strand breaks requires two rounds of replication whereas apoptosis is also induced in subsequent cell cycles.
    Quiros S; Roos WP; Kaina B
    Cell Cycle; 2010 Jan; 9(1):168-78. PubMed ID: 20016283
    [TBL] [Abstract][Full Text] [Related]  

  • 8. BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis.
    Kaina B; Ochs K; Grösch S; Fritz G; Lips J; Tomicic M; Dunkern T; Christmann M
    Prog Nucleic Acid Res Mol Biol; 2001; 68():41-54. PubMed ID: 11554312
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cytotoxicity, mutations and SCEs induced by methylating agents are reduced in CHO cells expressing an active mammalian O6-methylguanine-DNA methyltransferase gene.
    Bignami M; Terlizzese M; Zijno A; Calcagnile A; Frosina G; Abbondandolo A; Dogliotti E
    Carcinogenesis; 1987 Oct; 8(10):1417-21. PubMed ID: 3115613
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Loss of ATM sensitizes against O6-methylguanine triggered apoptosis, SCEs and chromosomal aberrations.
    Debiak M; Nikolova T; Kaina B
    DNA Repair (Amst); 2004 Apr; 3(4):359-68. PubMed ID: 15010311
    [TBL] [Abstract][Full Text] [Related]  

  • 11. On the quantitative relationship between O6-methylguanine residues in genomic DNA and production of sister-chromatid exchanges, mutations and lethal events in a Mer- human tumor cell line.
    Rasouli-Nia A; Sibghat-Ullah ; Mirzayans R; Paterson MC; Day RS
    Mutat Res; 1994 Mar; 314(2):99-113. PubMed ID: 7510369
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Repair of O(6)-methylguanine is not affected by thymine base pairing and the presence of MMR proteins.
    Lips J; Kaina B
    Mutat Res; 2001 Nov; 487(1-2):59-66. PubMed ID: 11595409
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Strand- and sequence-specific attenuation of N-methyl-N'-nitro-N-nitrosoguanidine-induced G.C to A.T transitions by expression of human 6-methylguanine-DNA methyltransferase in Chinese hamster ovary cells.
    Yang JL; Hsieh FP; Lee PC; Tseng HJ
    Cancer Res; 1994 Jul; 54(14):3857-63. PubMed ID: 8033107
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The bacterial alkyltransferase-like (eATL) protein protects mammalian cells against methylating agent-induced toxicity.
    Tomaszowski KH; Aasland D; Margison GP; Williams E; Pinder SI; Modesti M; Fuchs RP; Kaina B
    DNA Repair (Amst); 2015 Apr; 28():14-20. PubMed ID: 25703834
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inducibility of the DNA repair gene encoding O6-methylguanine-DNA methyltransferase in mammalian cells by DNA-damaging treatments.
    Fritz G; Tano K; Mitra S; Kaina B
    Mol Cell Biol; 1991 Sep; 11(9):4660-8. PubMed ID: 1875945
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Comparison of repair of O6-methylguanine produced by N-methyl-N'-nitro-N-nitrosoguanidine in mouse and human cells.
    Yagi T; Yarosh DB; Day RS
    Carcinogenesis; 1984 May; 5(5):593-600. PubMed ID: 6722979
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1.
    Roos W; Baumgartner M; Kaina B
    Oncogene; 2004 Jan; 23(2):359-67. PubMed ID: 14724564
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Critical steps in alkylation-induced aberration formation.
    Kaina B
    Mutat Res; 1998 Aug; 404(1-2):119-24. PubMed ID: 9729324
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The induction of SCE and chromosomal aberrations with relation to specific base methylation of DNA in Chinese hamster cells by N-methyl-N-nitrosourea and dimethyl sulphate.
    Connell JR; Medcalf AS
    Carcinogenesis; 1982; 3(4):385-90. PubMed ID: 7094205
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Dependency of the yield of sister-chromatid exchanges induced by alkylating agents on fixation time. Possible involvement of secondary lesions in sister-chromatid exchange induction.
    Kaina B; Aurich O
    Mutat Res; 1985 May; 149(3):451-61. PubMed ID: 3990696
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 50.