114 related articles for article (PubMed ID: 9438027)
1. Conformationally constrained analogues of the muscarinic agonist 3-(4-(methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyr idine. Synthesis, receptor affinity, and antinociceptive activity.
Sauerberg P; Olesen PH; Sheardown MJ; Rimvall K; Thøgersen H; Shannon HE; Sawyer BD; Ward JS; Bymaster FP; DeLapp NW; Calligaro DO; Swedberg MD
J Med Chem; 1998 Jan; 41(1):109-16. PubMed ID: 9438027
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and biological characterization of 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as muscarinic agonists for the treatment of neurological disorders.
Cao Y; Zhang M; Wu C; Lee S; Wroblewski ME; Whipple T; Nagy PI; Takács-Novák K; Balázs A; Torös S; Messer WS
J Med Chem; 2003 Sep; 46(20):4273-86. PubMed ID: 13678406
[TBL] [Abstract][Full Text] [Related]
3. 1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.0(2,6)]heptanes as new potent muscarinic M1 agonists: structure-activity relationship for 3-aryl-2-propyn-1-yloxy and 3-aryl-2-propyn-1-ylthio derivatives.
Jeppesen L; Olesen PH; Hansen L; Sheardown MJ; Thomsen C; Rasmussen T; Jensen AF; Christensen MS; Rimvall K; Ward JS; Whitesitt C; Calligaro DO; Bymaster FP; Delapp NW; Felder CC; Shannon HE; Sauerberg P
J Med Chem; 1999 Jun; 42(11):1999-2006. PubMed ID: 10354408
[TBL] [Abstract][Full Text] [Related]
4. M1 receptor agonist activity is not a requirement for muscarinic antinociception.
Sheardown MJ; Shannon HE; Swedberg MD; Suzdak PD; Bymaster FP; Olesen PH; Mitch CH; Ward JS; Sauerberg P
J Pharmacol Exp Ther; 1997 May; 281(2):868-75. PubMed ID: 9152396
[TBL] [Abstract][Full Text] [Related]
5. Design and synthesis of novel derivatives of the muscarinic agonist tetra(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether (CDD-0304): effects of structural modifications on the binding and activity at muscarinic receptor subtypes and chimeras.
Tejada FR; Nagy PI; Xu M; Wu C; Katz T; Dorsey J; Rieman M; Lawlor E; Warrier M; Messer WS
J Med Chem; 2006 Dec; 49(25):7518-31. PubMed ID: 17149881
[TBL] [Abstract][Full Text] [Related]
6. Muscarinic agonists with antipsychotic-like activity: structure-activity relationships of 1,2,5-thiadiazole analogues with functional dopamine antagonist activity.
Sauerberg P; Jeppesen L; Olesen PH; Rasmussen T; Swedberg MD; Sheardown MJ; Fink-Jensen A; Thomsen C; Thøgersen H; Rimvall K; Ward JS; Calligaro DO; DeLapp NW; Bymaster FP; Shannon HE
J Med Chem; 1998 Oct; 41(22):4378-84. PubMed ID: 9784113
[TBL] [Abstract][Full Text] [Related]
7. Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines .
Sauerberg P; Olesen PH; Nielsen S; Treppendahl S; Sheardown MJ; Honoré T; Mitch CH; Ward JS; Pike AJ; Bymaster FP
J Med Chem; 1992 Jun; 35(12):2274-83. PubMed ID: 1613751
[TBL] [Abstract][Full Text] [Related]
8. Muscarinic agonists as analgesics. Antinociceptive activity versus M1 activity: SAR of alkylthio-TZTP's and related 1,2,5-thiadiazole analogs.
Sauerberg P; Olesen PH; Sheardown MJ; Suzdak PD; Shannon HE; Bymaster FP; Calligaro DO; Mitch CH; Ward JS; Swedberg MD
Life Sci; 1995; 56(11-12):807-14. PubMed ID: 10188779
[TBL] [Abstract][Full Text] [Related]
9. Functional effects of the muscarinic receptor agonist, xanomeline, at 5-HT1 and 5-HT2 receptors.
Watson J; Brough S; Coldwell MC; Gager T; Ho M; Hunter AJ; Jerman J; Middlemiss DN; Riley GJ; Brown AM
Br J Pharmacol; 1998 Dec; 125(7):1413-20. PubMed ID: 9884068
[TBL] [Abstract][Full Text] [Related]
10. 6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors.
Pei XF; Gupta TH; Badio B; Padgett WL; Daly JW
J Med Chem; 1998 Jun; 41(12):2047-55. PubMed ID: 9622546
[TBL] [Abstract][Full Text] [Related]
11. Synthesis of 5-(4-alkylsulfanyl-[1, 2, 5]thiadiazol-3-yl)-3-methyl-1, 2, 3, 4-tetrahydropyrimidine oxalate salts and their evaluation as muscarinic receptor agonists.
Jung MH; Park JG; Park WK
Arch Pharm (Weinheim); 2003 Jul; 336(4-5):230-5. PubMed ID: 12916057
[TBL] [Abstract][Full Text] [Related]
12. 1,2,5-Thiadiazole analogues of aceclidine as potent m1 muscarinic agonists.
Ward JS; Merritt L; Calligaro DO; Bymaster FP; Shannon HE; Mitch CH; Whitesitt C; Brunsting D; Sheardown MJ; Olesen PH; Swedberg MD; Jeppesen L; Sauerberg P
J Med Chem; 1998 Jan; 41(3):379-92. PubMed ID: 9464368
[TBL] [Abstract][Full Text] [Related]
13. Synthesis and evaluation of xanomeline analogs--probing the wash-resistant phenomenon at the M1 muscarinic acetylcholine receptor.
Kane BE; Grant MK; El-Fakahany EE; Ferguson DM
Bioorg Med Chem; 2008 Feb; 16(3):1376-92. PubMed ID: 17977730
[TBL] [Abstract][Full Text] [Related]
14. Differences in kinetics of xanomeline binding and selectivity of activation of G proteins at M(1) and M(2) muscarinic acetylcholine receptors.
Jakubík J; El-Fakahany EE; Dolezal V
Mol Pharmacol; 2006 Aug; 70(2):656-66. PubMed ID: 16675658
[TBL] [Abstract][Full Text] [Related]
15. 6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors.
Daly JW; Gupta TH; Padgett WL; Pei XF
J Med Chem; 2000 Jun; 43(13):2514-22. PubMed ID: 10891110
[TBL] [Abstract][Full Text] [Related]
16. Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic m1 receptor activation.
Sauerberg P; Jeppesen L; Olesen PH; Sheardown MJ; Fink-Jensen A; Rasmussen T; Rimvall K; Shannon HE; Bymaster FP; DeLapp NW; Calligaro DO; Ward JS; Whitesitt CA; Thomsen C
Bioorg Med Chem Lett; 1998 Oct; 8(20):2897-902. PubMed ID: 9873644
[TBL] [Abstract][Full Text] [Related]
17. Design, synthesis, and biological characterization of bivalent 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as selective muscarinic agonists.
Rajeswaran WG; Cao Y; Huang XP; Wroblewski ME; Colclough T; Lee S; Liu F; Nagy PI; Ellis J; Levine BA; Nocka KH; Messer WS
J Med Chem; 2001 Dec; 44(26):4563-76. PubMed ID: 11741475
[TBL] [Abstract][Full Text] [Related]
18. Discovery of a highly potent, functionally-selective muscarinic M1 agonist, WAY-132983 using rational drug design and receptor modelling.
Sabb AL; Husbands GM; Tokolics J; Stein RP; Tasse RP; Boast CA; Moyer JA; Abou-Gharbia M
Bioorg Med Chem Lett; 1999 Jul; 9(14):1895-900. PubMed ID: 10450949
[TBL] [Abstract][Full Text] [Related]
19. Wash-resistantly bound xanomeline inhibits acetylcholine release by persistent activation of presynaptic M(2) and M(4) muscarinic receptors in rat brain.
Machová E; Jakubík J; El-Fakahany EE; Dolezal V
J Pharmacol Exp Ther; 2007 Jul; 322(1):316-23. PubMed ID: 17446301
[TBL] [Abstract][Full Text] [Related]
20. On the unique binding and activating properties of xanomeline at the M1 muscarinic acetylcholine receptor.
Christopoulos A; Pierce TL; Sorman JL; El-Fakahany EE
Mol Pharmacol; 1998 Jun; 53(6):1120-30. PubMed ID: 9614217
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
