These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
145 related articles for article (PubMed ID: 9456306)
1. Microsomal formation of a pyrrolic alcohol glutathione conjugate of clivorine. Firm evidence for the formation of a pyrrolic metabolite of an otonecine-type pyrrolizidine alkaloid. Lin G; Cui YY; Hawes EM Drug Metab Dispos; 1998 Feb; 26(2):181-4. PubMed ID: 9456306 [TBL] [Abstract][Full Text] [Related]
2. Characterization of rat liver microsomal metabolites of clivorine, an hepatotoxic otonecine-type pyrrolizidine alkaloid. Lin G; Cui YY; Hawes EM Drug Metab Dispos; 2000 Dec; 28(12):1475-83. PubMed ID: 11095586 [TBL] [Abstract][Full Text] [Related]
3. 9-Glutathionyl-6,7-dihydro-1-hydroxymethyl-5H-pyrrolizine Is the Major Pyrrolic Glutathione Conjugate of Retronecine-Type Pyrrolizidine Alkaloids in Liver Microsomes and in Rats. Chen M; Li L; Zhong D; Shen S; Zheng J; Chen X Chem Res Toxicol; 2016 Feb; 29(2):180-9. PubMed ID: 26761523 [TBL] [Abstract][Full Text] [Related]
4. Microsomal formation of a pyrrolic alcohol glutathione conjugate of the pyrrolizidine alkaloid senecionine. Reed RL; Miranda CL; Kedzierski B; Henderson MC; Buhler DR Xenobiotica; 1992 Nov; 22(11):1321-7. PubMed ID: 1492424 [TBL] [Abstract][Full Text] [Related]
5. Metabolic formation of DHP-derived DNA adducts from a representative otonecine type pyrrolizidine alkaloid clivorine and the extract of Ligularia hodgsonnii hook. Xia Q; Chou MW; Lin G; Fu PP Chem Res Toxicol; 2004 May; 17(5):702-8. PubMed ID: 15144228 [TBL] [Abstract][Full Text] [Related]
6. Species differences in the in vitro metabolic activation of the hepatotoxic pyrrolizidine alkaloid clivorine. Lin G; Cui YY; Liu XQ; Wang ZT Chem Res Toxicol; 2002 Nov; 15(11):1421-8. PubMed ID: 12437333 [TBL] [Abstract][Full Text] [Related]
7. New glutathione conjugate of pyrrolizidine alkaloids produced by human cytosolic enzyme-dependent reactions in vitro. Muluneh F; Häkkinen MR; El-Dairi R; Pasanen M; Juvonen RO Rapid Commun Mass Spectrom; 2018 Aug; 32(16):1344-1352. PubMed ID: 29788543 [TBL] [Abstract][Full Text] [Related]
8. Comparison of metabolism-mediated effects of pyrrolizidine alkaloids in a HepG2/C3A cell-S9 co-incubation system and quantification of their glutathione conjugates. Tamta H; Pawar RS; Wamer WG; Grundel E; Krynitsky AJ; Rader JI Xenobiotica; 2012 Oct; 42(10):1038-48. PubMed ID: 22519982 [TBL] [Abstract][Full Text] [Related]
9. Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine. Xia Q; Yan J; Chou MW; Fu PP Toxicol Lett; 2008 May; 178(2):77-82. PubMed ID: 18395999 [TBL] [Abstract][Full Text] [Related]
10. Pyrrolizidine Alkaloid Secondary Pyrrolic Metabolites Construct Multiple Activation Pathways Leading to DNA Adduct Formation and Potential Liver Tumor Initiation. Xia Q; He X; Ma L; Chen S; Fu PP Chem Res Toxicol; 2018 Jul; 31(7):619-628. PubMed ID: 29855181 [TBL] [Abstract][Full Text] [Related]
11. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Wang YP; Yan J; Fu PP; Chou MW Toxicol Lett; 2005 Mar; 155(3):411-20. PubMed ID: 15649625 [TBL] [Abstract][Full Text] [Related]
12. Gender differences in microsomal metabolic activation of hepatotoxic clivorine in rat. Lin G; Cui YY; Liu XQ Chem Res Toxicol; 2003 Jun; 16(6):768-74. PubMed ID: 12807360 [TBL] [Abstract][Full Text] [Related]
13. Lack of metabolic activation and predominant formation of an excreted metabolite of nontoxic platynecine-type pyrrolizidine alkaloids. Ruan J; Liao C; Ye Y; Lin G Chem Res Toxicol; 2014 Jan; 27(1):7-16. PubMed ID: 24308637 [TBL] [Abstract][Full Text] [Related]
14. Effects of glutathione and cysteine on pyrrolizidine alkaloid-induced hepatotoxicity and DNA adduct formation in rat primary hepatocytes. He X; Xia Q; Shi Q; Fu PP J Environ Sci Health C Toxicol Carcinog; 2020; 38(2):109-123. PubMed ID: 32500832 [TBL] [Abstract][Full Text] [Related]
15. Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, lasiocarpine. Xia Q; Chou MW; Edgar JA; Doerge DR; Fu PP Cancer Lett; 2006 Jan; 231(1):138-45. PubMed ID: 16356839 [TBL] [Abstract][Full Text] [Related]
16. Deacetylclivorine: a gender-selective metabolite of clivorine formed in female Sprague-Dawley rat liver microsomes. Lin G; Tang J; Liu XQ; Jiang Y; Zheng J Drug Metab Dispos; 2007 Apr; 35(4):607-13. PubMed ID: 17237157 [TBL] [Abstract][Full Text] [Related]
17. The comparative metabolism of the four pyrrolizidine alkaloids, seneciphylline, retrorsine, monocrotaline, and trichodesmine in the isolated, perfused rat liver. Yan CC; Cooper RA; Huxtable RJ Toxicol Appl Pharmacol; 1995 Aug; 133(2):277-84. PubMed ID: 7645024 [TBL] [Abstract][Full Text] [Related]
18. Pyrrolizidine alkaloid-derived DNA adducts as a common biological biomarker of pyrrolizidine alkaloid-induced tumorigenicity. Xia Q; Zhao Y; Von Tungeln LS; Doerge DR; Lin G; Cai L; Fu PP Chem Res Toxicol; 2013 Sep; 26(9):1384-96. PubMed ID: 23937665 [TBL] [Abstract][Full Text] [Related]
19. Pyrrolic and N-oxide metabolites formed from pyrrolizidine alkaloids by hepatic microsomes in vitro: relevance to in vivo hepatotoxicity. Mattocks AR; Bird I Chem Biol Interact; 1983 Feb; 43(2):209-22. PubMed ID: 6825198 [TBL] [Abstract][Full Text] [Related]
20. Comparative Study of Hepatotoxicity of Pyrrolizidine Alkaloids Retrorsine and Monocrotaline. Yang X; Li W; Sun Y; Guo X; Huang W; Peng Y; Zheng J Chem Res Toxicol; 2017 Feb; 30(2):532-539. PubMed ID: 28095673 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]