BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

264 related articles for article (PubMed ID: 9473295)

  • 21. Enzymatic determinants of the substrate specificity of CYP2C9: role of B'-C loop residues in providing the pi-stacking anchor site for warfarin binding.
    Haining RL; Jones JP; Henne KR; Fisher MB; Koop DR; Trager WF; Rettie AE
    Biochemistry; 1999 Mar; 38(11):3285-92. PubMed ID: 10079071
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Structural determinants of progesterone hydroxylation by cytochrome P450 2B5: the role of nonsubstrate recognition site residues.
    He YQ; Harlow GR; Szklarz GD; Halpert JR
    Arch Biochem Biophys; 1998 Feb; 350(2):333-9. PubMed ID: 9473309
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues.
    He YQ; Szklarz GD; Halpert JR
    Arch Biochem Biophys; 1996 Nov; 335(1):152-60. PubMed ID: 8914846
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Filling a hole in cytochrome P450 BM3 improves substrate binding and catalytic efficiency.
    Huang WC; Westlake AC; Maréchal JD; Joyce MG; Moody PC; Roberts GC
    J Mol Biol; 2007 Oct; 373(3):633-51. PubMed ID: 17868686
    [TBL] [Abstract][Full Text] [Related]  

  • 25. A conserved proline-rich sequence between the N-terminal signal-anchor and catalytic domains is required for assembly of functional cytochrome P450 2C2.
    Chen CD; Doray B; Kemper B
    Arch Biochem Biophys; 1998 Feb; 350(2):233-8. PubMed ID: 9473296
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes.
    Yamazaki H; Shaw PM; Guengerich FP; Shimada T
    Chem Res Toxicol; 1998 Jun; 11(6):659-65. PubMed ID: 9625734
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics.
    Harlow GR; Halpert JR
    Proc Natl Acad Sci U S A; 1998 Jun; 95(12):6636-41. PubMed ID: 9618464
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms.
    Haining RL; Hunter AP; Veronese ME; Trager WF; Rettie AE
    Arch Biochem Biophys; 1996 Sep; 333(2):447-58. PubMed ID: 8809086
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Threonine-205 in the F helix of p450 2B1 contributes to androgen 16 beta-hydroxylation activity and mechanism-based inactivation.
    Lin HL; Zhang H; Waskell L; Hollenberg PF
    J Pharmacol Exp Ther; 2003 Aug; 306(2):744-51. PubMed ID: 12721329
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Metabolic activation of diclofenac by human cytochrome P450 3A4: role of 5-hydroxydiclofenac.
    Shen S; Marchick MR; Davis MR; Doss GA; Pohl LR
    Chem Res Toxicol; 1999 Feb; 12(2):214-22. PubMed ID: 10027801
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4.
    Szklarz GD; He YQ; Kedzie KM; Halpert JR; Burnett VL
    Arch Biochem Biophys; 1996 Mar; 327(2):308-18. PubMed ID: 8619620
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Site-directed mutagenesis of residues in a conserved region of bovine aspartyl (asparaginyl) beta-hydroxylase: evidence that histidine 675 has a role in binding Fe2+.
    McGinnis K; Ku GM; VanDusen WJ; Fu J; Garsky V; Stern AM; Friedman PA
    Biochemistry; 1996 Apr; 35(13):3957-62. PubMed ID: 8672427
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Homology modeling and substrate binding study of human CYP4A11 enzyme.
    Chang YT; Loew GH
    Proteins; 1999 Feb; 34(3):403-15. PubMed ID: 10024026
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Molecular basis of P450 inhibition and activation: implications for drug development and drug therapy.
    Szklarz GD; Halpert JR
    Drug Metab Dispos; 1998 Dec; 26(12):1179-84. PubMed ID: 9860924
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Site-directed mutagenesis of putative substrate recognition sites in cytochrome P450 2B11: importance of amino acid residues 114, 290, and 363 for substrate specificity.
    Hasler JA; Harlow GR; Szklarz GD; John GH; Kedzie KM; Burnett VL; He YA; Kaminsky LS; Halpert JR
    Mol Pharmacol; 1994 Aug; 46(2):338-45. PubMed ID: 8078495
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Roles of human hepatic cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac.
    Tang W; Stearns RA; Wang RW; Chiu SH; Baillie TA
    Chem Res Toxicol; 1999 Feb; 12(2):192-9. PubMed ID: 10027798
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Alterations of the regiospecificity of progesterone metabolism by the mutagenesis of two key amino acid residues in rabbit cytochrome P450 2C3v.
    Richardson TH; Johnson EF
    J Biol Chem; 1994 Sep; 269(39):23937-43. PubMed ID: 7929041
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by alpha-naphthoflavone.
    Schwab GE; Raucy JL; Johnson EF
    Mol Pharmacol; 1988 May; 33(5):493-9. PubMed ID: 3367901
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Molecular recognition in (+)-alpha-pinene oxidation by cytochrome P450cam.
    Bell SG; Chen X; Sowden RJ; Xu F; Williams JN; Wong LL; Rao Z
    J Am Chem Soc; 2003 Jan; 125(3):705-14. PubMed ID: 12526670
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Role of residues 363 and 206 in conversion of cytochrome P450 2B1 from a steroid 16-hydroxylase to a 15 alpha-hydroxylase.
    Luo Z; He YA; Halpert JR
    Arch Biochem Biophys; 1994 Feb; 309(1):52-7. PubMed ID: 8117113
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 14.