BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

235 related articles for article (PubMed ID: 9473470)

  • 1. Retroviral coexpression of thymidylate synthase and dihydrofolate reductase confers fluoropyrimidine and antifolate resistance.
    Fantz CR; Shaw D; Moore JG; Spencer HT
    Biochem Biophys Res Commun; 1998 Feb; 243(1):6-12. PubMed ID: 9473470
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Protection of hematopoietic stem cells from pemetrexed toxicity by retroviral gene transfer with a mutant dihydrofolate reductase-mutant thymidylate synthase fusion gene.
    Capiaux GM; Budak-Alpdogan T; Alpdogan O; Bornmann W; Takebe N; Banerjee D; Maley F; Bertino JR
    Cancer Gene Ther; 2004 Dec; 11(12):767-73. PubMed ID: 15359285
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Engineered resistance to camptothecin and antifolates by retroviral coexpression of tyrosyl DNA phosphodiesterase-I and thymidylate synthase.
    Nivens MC; Felder T; Galloway AH; Pena MM; Pouliot JJ; Spencer HT
    Cancer Chemother Pharmacol; 2004 Feb; 53(2):107-15. PubMed ID: 14605862
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Retroviral vectors containing a variant dihydrofolate reductase gene for drug protection and in vivo selection of hematopoietic cells.
    Allay JA; Galipeau J; Blakley RL; Sorrentino BP
    Stem Cells; 1998; 16 Suppl 1():223-33. PubMed ID: 11012166
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Increased resistance to nitrogen mustards and antifolates following in vitro selection of murine fibroblasts and primary hematopoietic cells transduced with a bicistronic retroviral vector expressing the rat glutathione S-transferase A3 and a mutant dihydrofolate reductase.
    Belzile JP; Karatzas A; Shiu HY; Létourneau S; Palerme JS; Cournoyer D
    Cancer Gene Ther; 2003 Aug; 10(8):637-46. PubMed ID: 12872145
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Protection of CCRF-CEM human lymphoid cells from antifolates by retroviral gene transfer of variants of murine dihydrofolate reductase.
    Mareya SM; Sorrentino BP; Blakley RL
    Cancer Gene Ther; 1998; 5(4):225-35. PubMed ID: 9694074
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254.
    Fantz C; Shaw D; Jennings W; Forsthoefel A; Kitchens M; Phan J; Minor W; Lebioda L; Berger FG; Spencer HT
    Mol Pharmacol; 2000 Feb; 57(2):359-66. PubMed ID: 10648646
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies.
    Jackman AL; Alison DL; Calvert AH; Harrap KR
    Cancer Res; 1986 Jun; 46(6):2810-5. PubMed ID: 2938731
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Retroviral transduction of a mutant dihydrofolate reductase-thymidylate synthase fusion gene into murine marrow cells confers resistance to both methotrexate and 5-fluorouracil.
    Capiaux GM; Budak-Alpdogan T; Takebe N; Mayer-Kuckuk P; Banerjee D; Maley F; Bertino JR
    Hum Gene Ther; 2003 Mar; 14(5):435-46. PubMed ID: 12691609
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Comparison of methotrexate resistance conferred by a mutated dihydrofolate reductase (DHFR) cDNA in two different retroviral vectors.
    Takebe N; Nakahara S; Zhao SC; Adhikari D; Ural AU; Iwamoto M; Banerjee D; Bertino JR
    Cancer Gene Ther; 2000 Jun; 7(6):910-9. PubMed ID: 10880023
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate.
    Senkovich O; Schormann N; Chattopadhyay D
    Acta Crystallogr D Biol Crystallogr; 2009 Jul; 65(Pt 7):704-16. PubMed ID: 19564691
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Heterologous expression and characterization of the bifunctional dihydrofolate reductase-thymidylate synthase enzyme of Toxoplasma gondii.
    Trujillo M; Donald RG; Roos DS; Greene PJ; Santi DV
    Biochemistry; 1996 May; 35(20):6366-74. PubMed ID: 8639582
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Selective expression of methotrexate-resistant dihydrofolate reductase (DHFR) activity in mice transduced with DHFR retrovirus and administered methotrexate.
    Vinh DB; McIvor RS
    J Pharmacol Exp Ther; 1993 Nov; 267(2):989-96. PubMed ID: 8246174
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A naturally occurring tyrosine to histidine replacement at residue 33 of human thymidylate synthase confers resistance to 5-fluoro-2'-deoxyuridine in mammalian and bacterial cells.
    Barbour KW; Hoganson DK; Berger SH; Berger FG
    Mol Pharmacol; 1992 Aug; 42(2):242-8. PubMed ID: 1355260
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Retroviral expression of Escherichia coli thymidylate synthase cDNA confers high-level antifolate resistance to hematopoietic cells.
    Shaw D; Berger FG; Spencer HT
    Hum Gene Ther; 2001 Jan; 12(1):51-9. PubMed ID: 11177542
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Generation of dual resistance to 4-hydroperoxycyclophosphamide and methotrexate by retroviral transfer of the human aldehyde dehydrogenase class 1 gene and a mutated dihydrofolate reductase gene.
    Takebe N; Zhao SC; Adhikari D; Mineishi S; Sadelain M; Hilton J; Colvin M; Banerjee D; Bertino JR
    Mol Ther; 2001 Jan; 3(1):88-96. PubMed ID: 11162315
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Drug-resistant dihydrofolate reductases: generation, expression and therapeutic application.
    McIvor RS
    Bone Marrow Transplant; 1996 Dec; 18 Suppl 3():S50-4. PubMed ID: 8971409
    [TBL] [Abstract][Full Text] [Related]  

  • 18. In vitro mutations in dihydrofolate reductase that confer resistance to methotrexate: potential for clinical application.
    Blakley RL; Sorrentino BP
    Hum Mutat; 1998; 11(4):259-63. PubMed ID: 9554740
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Methotrexate selection of long-term culture initiating cells following transduction of CD34(+) cells with a retrovirus containing a mutated human dihydrofolate reductase gene.
    Takebe N; Xu LC; MacKenzie KL; Bertino JR; Moore MA
    Cancer Gene Ther; 2002 Mar; 9(3):308-20. PubMed ID: 11896448
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells.
    Berger SH; Jenh CH; Johnson LF; Berger FG
    Mol Pharmacol; 1985 Nov; 28(5):461-7. PubMed ID: 2932632
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.