BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

108 related articles for article (PubMed ID: 9474242)

  • 1. Antineoplastic agents 360. Synthesis and cancer cell growth inhibitory studies of dolastatin 15 structural modifications.
    Pettit GR; Flahive EJ; Boyd MR; Bai R; Hamel E; Pettit RK; Schmidt JM
    Anticancer Drug Des; 1998 Jan; 13(1):47-66. PubMed ID: 9474242
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Antineoplastic agents 337. Synthesis of dolastatin 10 structural modifications.
    Pettit GR; Srirangam JK; Barkoczy J; Williams MD; Durkin KP; Boyd MR; Bai R; Hamel E; Schmidt JM; Chapuis JC
    Anticancer Drug Des; 1995 Oct; 10(7):529-44. PubMed ID: 7495477
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Antineoplastic agents 365. Dolastatin 10 SAR probes.
    Pettit GR; Srirangam JK; Barkoczy J; Williams MD; Boyd MR; Hamel E; Pettit RK; Hogan F; Bai R; Chapuis JC; McAllister SC; Schmidt JM
    Anticancer Drug Des; 1998 Jun; 13(4):243-77. PubMed ID: 9627667
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Differential effects of active isomers, segments, and analogs of dolastatin 10 on ligand interactions with tubulin. Correlation with cytotoxicity.
    Bai R; Roach MC; Jayaram SK; Barkoczy J; Pettit GR; Ludueña RF; Hamel E
    Biochem Pharmacol; 1993 Apr; 45(7):1503-15. PubMed ID: 8471072
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules.
    Bai R; Friedman SJ; Pettit GR; Hamel E
    Biochem Pharmacol; 1992 Jun; 43(12):2637-45. PubMed ID: 1632820
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure-activity studies with chiral isomers and with segments of the antimitotic marine peptide dolastatin 10.
    Bai RL; Pettit GR; Hamel E
    Biochem Pharmacol; 1990 Oct; 40(8):1859-64. PubMed ID: 2242019
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain.
    Bai R; Pettit GR; Hamel E
    Biochem Pharmacol; 1990 Jun; 39(12):1941-9. PubMed ID: 2353935
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and biological activity of chimeric structures derived from the cytotoxic natural compounds dolastatin 10 and dolastatin 15.
    Poncet J; Busquet M; Roux F; Pierré A; Atassi G; Jouin P
    J Med Chem; 1998 Apr; 41(9):1524-30. PubMed ID: 9554885
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and X-ray crystal structure of the dolabellaauricularia peptide dolastatin 18.
    Pettit GR; Hogan F; Herald DL
    J Org Chem; 2004 Jun; 69(12):4019-22. PubMed ID: 15176826
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Interaction of marine toxin dolastatin 10 with porcine brain tubulin: competitive inhibition of rhizoxin and phomopsin A binding.
    Li Y; Kobayashi H; Hashimoto Y; Shirai R; Hirata A; Hayashi K; Hamada Y; Shioiri T; Iwasaki S
    Chem Biol Interact; 1994 Dec; 93(3):175-83. PubMed ID: 7923438
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Antitumour evaluation of dolastatins 10 and 15 and their measurement in plasma by radioimmunoassay.
    Aherne GW; Hardcastle A; Valenti M; Bryant A; Rogers P; Pettit GR; Srirangam JK; Kelland LR
    Cancer Chemother Pharmacol; 1996; 38(3):225-32. PubMed ID: 8646796
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Diazonamide A and a synthetic structural analog: disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin.
    Cruz-Monserrate Z; Vervoort HC; Bai R; Newman DJ; Howell SB; Los G; Mullaney JT; Williams MD; Pettit GR; Fenical W; Hamel E
    Mol Pharmacol; 2003 Jun; 63(6):1273-80. PubMed ID: 12761336
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis of Dolastatin 15 mimetic peptoids.
    Schmitt J; Bernd M; Kutscher B; Kessler H
    Bioorg Med Chem Lett; 1998 Feb; 8(4):385-8. PubMed ID: 9871690
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and cytostatic properties of structure-simplified analogs of dolastatin 15.
    Hu MK; Huang WS
    J Pept Res; 1999 Dec; 54(6):460-7. PubMed ID: 10604591
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Successful treatment of human chronic lymphocytic leukemia xenografts with combination biological agents auristatin PE and bryostatin 1.
    Mohammad RM; Varterasian ML; Almatchy VP; Hannoudi GN; Pettit GR; Al-Katib A
    Clin Cancer Res; 1998 May; 4(5):1337-43. PubMed ID: 9607595
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain.
    Bai R; Taylor GF; Cichacz ZA; Herald CL; Kepler JA; Pettit GR; Hamel E
    Biochemistry; 1995 Aug; 34(30):9714-21. PubMed ID: 7626642
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Treatment of human prostate cancer cells with dolastatin 10, a peptide isolated from a marine shell-less mollusc.
    Turner T; Jackson WH; Pettit GR; Wells A; Kraft AS
    Prostate; 1998 Feb; 34(3):175-81. PubMed ID: 9492845
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The dolastatins, a family of promising antineoplastic agents.
    Poncet J
    Curr Pharm Des; 1999 Mar; 5(3):139-62. PubMed ID: 10066887
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The molecular pharmacology of symplostatin 1: a new antimitotic dolastatin 10 analog.
    Mooberry SL; Leal RM; Tinley TL; Luesch H; Moore RE; Corbett TH
    Int J Cancer; 2003 Apr; 104(4):512-21. PubMed ID: 12584751
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Dolastatin 11, a marine depsipeptide, arrests cells at cytokinesis and induces hyperpolymerization of purified actin.
    Bai R; Verdier-Pinard P; Gangwar S; Stessman CC; McClure KJ; Sausville EA; Pettit GR; Bates RB; Hamel E
    Mol Pharmacol; 2001 Mar; 59(3):462-9. PubMed ID: 11179440
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.