303 related articles for article (PubMed ID: 9484239)
1. Alzheimer's amyloid precursor protein alpha-secretase is inhibited by hydroxamic acid-based zinc metalloprotease inhibitors: similarities to the angiotensin converting enzyme secretase.
Parvathy S; Hussain I; Karran EH; Turner AJ; Hooper NM
Biochemistry; 1998 Feb; 37(6):1680-5. PubMed ID: 9484239
[TBL] [Abstract][Full Text] [Related]
2. Angiotensin-converting enzyme secretase is inhibited by zinc metalloprotease inhibitors and requires its substrate to be inserted in a lipid bilayer.
Parvathy S; Oppong SY; Karran EH; Buckle DR; Turner AJ; Hooper NM
Biochem J; 1997 Oct; 327 ( Pt 1)(Pt 1):37-43. PubMed ID: 9355732
[TBL] [Abstract][Full Text] [Related]
3. Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells.
Parvathy S; Hussain I; Karran EH; Turner AJ; Hooper NM
Biochemistry; 1999 Jul; 38(30):9728-34. PubMed ID: 10423252
[TBL] [Abstract][Full Text] [Related]
4. Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells.
Peng Y; Jiang L; Lee DY; Schachter SC; Ma Z; Lemere CA
J Neurosci Res; 2006 Sep; 84(4):903-11. PubMed ID: 16862548
[TBL] [Abstract][Full Text] [Related]
5. Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding.
Parvathy S; Ehrlich M; Pedrini S; Diaz N; Refolo L; Buxbaum JD; Bogush A; Petanceska S; Gandy S
J Neurochem; 2004 Aug; 90(4):1005-10. PubMed ID: 15287907
[TBL] [Abstract][Full Text] [Related]
6. The role of proteolysis in Alzheimer's disease.
Hooper NM; Trew AJ; Parkin ET; Turner AJ
Adv Exp Med Biol; 2000; 477():379-90. PubMed ID: 10849764
[TBL] [Abstract][Full Text] [Related]
7. APPepsilon, the epsilon-secretase-derived N-terminal product of the beta-amyloid precursor protein, behaves as a type I protein and undergoes alpha-, beta-, and gamma-secretase cleavages.
Lefranc-Jullien S; Sunyach C; Checler F
J Neurochem; 2006 May; 97(3):807-17. PubMed ID: 16524370
[TBL] [Abstract][Full Text] [Related]
8. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
Wiley JC; Hudson M; Kanning KC; Schecterson LC; Bothwell M
J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
[TBL] [Abstract][Full Text] [Related]
9. Processing of the Alzheimer's disease amyloid precursor protein in Pichia pastoris: immunodetection of alpha-, beta-, and gamma-secretase products.
Le Brocque D; Henry A; Cappai R; Li QX; Tanner JE; Galatis D; Gray C; Holmes S; Underwood JR; Beyreuther K; Masters CL; Evin G
Biochemistry; 1998 Oct; 37(42):14958-65. PubMed ID: 9778373
[TBL] [Abstract][Full Text] [Related]
10. In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc.
Hoke DE; Tan JL; Ilaya NT; Culvenor JG; Smith SJ; White AR; Masters CL; Evin GM
FEBS J; 2005 Nov; 272(21):5544-57. PubMed ID: 16262694
[TBL] [Abstract][Full Text] [Related]
11. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
Yan R; Bienkowski MJ; Shuck ME; Miao H; Tory MC; Pauley AM; Brashier JR; Stratman NC; Mathews WR; Buhl AE; Carter DB; Tomasselli AG; Parodi LA; Heinrikson RL; Gurney ME
Nature; 1999 Dec; 402(6761):533-7. PubMed ID: 10591213
[TBL] [Abstract][Full Text] [Related]
12. Proprotein convertase activity contributes to the processing of the Alzheimer's beta-amyloid precursor protein in human cells: evidence for a role of the prohormone convertase PC7 in the constitutive alpha-secretase pathway.
Lopez-Perez E; Seidah NG; Checler F
J Neurochem; 1999 Nov; 73(5):2056-62. PubMed ID: 10537065
[TBL] [Abstract][Full Text] [Related]
13. gamma-Secretase as a target for drug intervention in Alzheimer's disease.
Harrison T; Churcher I; Beher D
Curr Opin Drug Discov Devel; 2004 Sep; 7(5):709-19. PubMed ID: 15503873
[TBL] [Abstract][Full Text] [Related]
14. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
Vingtdeux V; Hamdane M; Gompel M; Bégard S; Drobecq H; Ghestem A; Grosjean ME; Kostanjevecki V; Grognet P; Vanmechelen E; Buée L; Delacourte A; Sergeant N
Neurobiol Dis; 2005 Nov; 20(2):625-37. PubMed ID: 15936948
[TBL] [Abstract][Full Text] [Related]
15. Purification and cloning of amyloid precursor protein beta-secretase from human brain.
Sinha S; Anderson JP; Barbour R; Basi GS; Caccavello R; Davis D; Doan M; Dovey HF; Frigon N; Hong J; Jacobson-Croak K; Jewett N; Keim P; Knops J; Lieberburg I; Power M; Tan H; Tatsuno G; Tung J; Schenk D; Seubert P; Suomensaari SM; Wang S; Walker D; Zhao J; McConlogue L; John V
Nature; 1999 Dec; 402(6761):537-40. PubMed ID: 10591214
[TBL] [Abstract][Full Text] [Related]
16. [Effect of an inhibitor of alpha-secretase metabolizing amyloid precursor protein on memory in rats].
Dubrovskaia NM; Nalivaeva NN; Turner AJ; Zhuravin IA
Zh Vyssh Nerv Deiat Im I P Pavlova; 2005; 55(6):725-8. PubMed ID: 16396478
[TBL] [Abstract][Full Text] [Related]
17. The secretases that cleave angiotensin converting enzyme and the amyloid precursor protein are distinct from tumour necrosis factor-alpha convertase.
Parvathy S; Karran EH; Turner AJ; Hooper NM
FEBS Lett; 1998 Jul; 431(1):63-5. PubMed ID: 9684866
[TBL] [Abstract][Full Text] [Related]
18. Secretase inhibitors for Alzheimer's disease: challenges of a promiscuous protease.
Pollack SJ; Lewis H
Curr Opin Investig Drugs; 2005 Jan; 6(1):35-47. PubMed ID: 15675602
[TBL] [Abstract][Full Text] [Related]
19. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
Li YM; Xu M; Lai MT; Huang Q; Castro JL; DiMuzio-Mower J; Harrison T; Lellis C; Nadin A; Neduvelil JG; Register RB; Sardana MK; Shearman MS; Smith AL; Shi XP; Yin KC; Shafer JA; Gardell SJ
Nature; 2000 Jun; 405(6787):689-94. PubMed ID: 10864326
[TBL] [Abstract][Full Text] [Related]
20. Modulation of neurosteroid production in human neuroblastoma cells by Alzheimer's disease key proteins.
Schaeffer V; Patte-Mensah C; Eckert A; Mensah-Nyagan AG
J Neurobiol; 2006 Jul; 66(8):868-81. PubMed ID: 16673391
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]