BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

231 related articles for article (PubMed ID: 9484499)

  • 1. Novel non-peptide fibrinogen receptor antagonists. 1. Synthesis and glycoprotein IIb-IIIa antagonistic activities of 1,3,4-trisubstituted 2-oxopiperazine derivatives incorporating side-chain functions of the RGDF peptide.
    Sugihara H; Fukushi H; Miyawaki T; Imai Y; Terashita Z; Kawamura M; Fujisawa Y; Kita S
    J Med Chem; 1998 Feb; 41(4):489-502. PubMed ID: 9484499
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Novel non-peptide GPIIb/IIIa antagonists: synthesis and biological activities of 2-[4-[2-(4-amidinobenzoylamino)-2-(substituted)acetyl]-3-(2-methoxy-2-oxoethyl)-2-oxopiperazinyl] acetic acids.
    Kitamura S; Fukushi H; Miyawaki T; Kawamura M; Terashita Z; Sugihara H; Naka T
    Chem Pharm Bull (Tokyo); 2001 Mar; 49(3):258-67. PubMed ID: 11253914
    [TBL] [Abstract][Full Text] [Related]  

  • 3. New platelet fibrinogen receptor glycoprotein IIb-IIIa antagonists: orally active series of N-alkylated amidines with a 6,6-bicyclic template.
    Okumura K; Shimazaki T; Aoki Y; Yamashita H; Tanaka E; Banba S; Yazawa K; Kibayashi K; Banno H
    J Med Chem; 1998 Oct; 41(21):4036-52. PubMed ID: 9767641
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Potent dibasic GPIIb/IIIa antagonists with reduced prolongation of bleeding time: synthesis and pharmacological evaluation of 2-oxopiperazine derivatives.
    Kitamura S; Fukushi H; Miyawaki T; Kawamura M; Konishi N; Terashita Z; Naka T
    J Med Chem; 2001 Jul; 44(15):2438-50. PubMed ID: 11448226
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Antagonism of the GPIIb/IIIa receptor with the nonpeptidic molecule BIBU52: inhibition of platelet aggregation in vitro and antithrombotic efficacy in vivo.
    Guth BD; Seewaldt-Becker E; Himmelsbach F; Weisenberger H; Müller TH
    J Cardiovasc Pharmacol; 1997 Aug; 30(2):261-72. PubMed ID: 9269956
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Antithrombotic effects of TAK-029, a novel GPIIb/IIIa antagonist, in guinea pigs: comparative studies with ticlopidine, clopidogrel, aspirin, prostaglandin E1 and argatroban.
    Kawamura M; Imura Y; Moriya N; Kita S; Fukushi H; Sugihara H; Nishikawa K; Terashita Z
    J Pharmacol Exp Ther; 1996 Apr; 277(1):502-10. PubMed ID: 8613960
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Pharmacological properties of YM-57029, a novel platelet glycoprotein IIb/IIIa antagonist.
    Moritani Y; Sato K; Shigenaga T; Hisamichi N; Ichihara M; Akamatsu S; Suzuki Ki; Nii T; Kaku S; Kawasaki T; Matsumoto Y; Inagaki O; Tomioka K; Yanagisawa I
    Eur J Pharmacol; 2002 Mar; 439(1-3):43-52. PubMed ID: 11937091
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Derivatives of tetrahydroisoquinoline: synthesis and initial evaluation of novel non-peptide antagonists of the alpha(IIb)beta(3)-integrin.
    Krysko AA; Krysko OL; Kabanova TA; Andronati SA; Kabanov VM
    Bioorg Med Chem Lett; 2010 Aug; 20(15):4444-6. PubMed ID: 20598885
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of an orally active non-peptide fibrinogen receptor antagonist based on the hydantoin scaffold.
    Stilz HU; Guba W; Jablonka B; Just M; Klingler O; König W; Wehner V; Zoller G
    J Med Chem; 2001 Apr; 44(8):1158-76. PubMed ID: 11312916
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery and structure--activity relationship studies of a novel and specific peptide motif, Pro-X-X-X-Asp-X, as a platelet fibrinogen receptor antagonist.
    Hayashi Y; Katada J; Sato Y; Igarashi K; Takiguchi Y; Harada T; Muramatsu M; Yasuda E; Uno I
    Bioorg Med Chem; 1998 Mar; 6(3):355-64. PubMed ID: 9568289
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Low molecular weight, non-peptide fibrinogen receptor antagonists.
    Alig L; Edenhofer A; Hadváry P; Hürzeler M; Knopp D; Müller M; Steiner B; Trzeciak A; Weller T
    J Med Chem; 1992 Nov; 35(23):4393-407. PubMed ID: 1447740
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design and synthesis of a series of indole glycoprotein IIb/IIIa inhibitors.
    Grumel V; Mérour JY; Lesur B; Giboulot T; Frydman A; Guillaumet G
    Eur J Med Chem; 2002 Jan; 37(1):45-62. PubMed ID: 11841874
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Preparation and pharmacological evaluation of novel glycoprotein (Gp) IIb/IIIa antagonists. 1. The selection of naphthalene derivatives.
    Ono S; Inoue Y; Yoshida T; Ashimori A; Kosaka K; Imada T; Fukaya C; Nakamura N
    Chem Pharm Bull (Tokyo); 1999 Dec; 47(12):1685-93. PubMed ID: 10748713
    [TBL] [Abstract][Full Text] [Related]  

  • 14. New orally active non-peptide fibrinogen receptor (GpIIb-IIIa) antagonists: identification of ethyl 3-[N-[4-[4-[amino[(ethoxycarbonyl) imino]methyl]phenyl]-1,3-thiazol-2-yl]-N-[1-[(ethoxycarbonyl)methyl]pip erid -4-yl]amino]propionate (SR 121787) as a potent and long-acting antithrombotic agent.
    Badorc A; Bordes MF; de Cointet P; Savi P; Bernat A; Lalé A; Petitou M; Maffrand JP; Herbert JM
    J Med Chem; 1997 Oct; 40(21):3393-401. PubMed ID: 9341914
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Peptidomimetics - antagonists of the fibrinogen receptors: molecular design, structures, properties and therapeutic applications.
    Andronati SA; Karaseva TL; Krysko AA
    Curr Med Chem; 2004 May; 11(9):1183-211. PubMed ID: 15134514
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Novel nonpeptide antiplatelet glycoprotein IIb/IIIa receptor antagonist, DMP754: receptor binding affinity and specificity.
    Mousa SA; Forsythe M; Lorelli W; Bozarth J; Xue CB; Wityak J; Sielecki TM; Olson RE; DeGrado W; Kapil R; Hussain M; Wexler R; Thoolen MJ; Reilly TM
    Coron Artery Dis; 1996 Oct; 7(10):767-74. PubMed ID: 8970768
    [TBL] [Abstract][Full Text] [Related]  

  • 17. GPIIb/IIIa integrin antagonists with the new conformational restriction unit, trisubstituted beta-amino acid derivatives, and a substituted benzamidine structure.
    Hayashi Y; Katada J; Harada T; Tachiki A; Iijima K; Takiguchi Y; Muramatsu M; Miyazaki H; Asari T; Okazaki T; Sato Y; Yasuda E; Yano M; Uno I; Ojima I
    J Med Chem; 1998 Jun; 41(13):2345-60. PubMed ID: 9632368
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Comparative efficacy of fibrinogen and platelet supplementation on the in vitro reversibility of competitive glycoprotein IIb/IIIa (alphaIIb/beta3) receptor-directed platelet inhibition.
    Li YF; Spencer FA; Becker RC
    Am Heart J; 2001 Aug; 142(2):204-10. PubMed ID: 11479455
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Platelet aggregation and fibrinogen binding in human, rhesus monkey, guinea-pig, hamster and rat blood: activation by ADP and a thrombin receptor peptide and inhibition by glycoprotein IIb/IIIa antagonists.
    Cook NS; Zerwes HG; Tapparelli C; Powling M; Singh J; Metternich R; Hagenbach A
    Thromb Haemost; 1993 Sep; 70(3):531-9. PubMed ID: 8259560
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Arginyl-glycyl-aspartyl (RGD) epitope of human apolipoprotein (a) inhibits platelet aggregation by antagonizing the IIb subunit of the fibrinogen (GPIIb/IIIa) receptor.
    Barre DE
    Thromb Res; 2007; 119(5):601-7. PubMed ID: 16860375
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.