145 related articles for article (PubMed ID: 9485372)
1. Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family.
Grunberg J; Walter J; Loetscher H; Deuschle U; Jacobsen H; Haass C
Biochemistry; 1998 Feb; 37(8):2263-70. PubMed ID: 9485372
[TBL] [Abstract][Full Text] [Related]
2. Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms.
Walter J; Grünberg J; Schindzielorz A; Haass C
Biochemistry; 1998 Apr; 37(17):5961-7. PubMed ID: 9558331
[TBL] [Abstract][Full Text] [Related]
3. Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.
Podlisny MB; Citron M; Amarante P; Sherrington R; Xia W; Zhang J; Diehl T; Levesque G; Fraser P; Haass C; Koo EH; Seubert P; St George-Hyslop P; Teplow DB; Selkoe DJ
Neurobiol Dis; 1997; 3(4):325-37. PubMed ID: 9173929
[TBL] [Abstract][Full Text] [Related]
4. Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments.
Prokop S; Haass C; Steiner H
J Neurochem; 2005 Jul; 94(1):57-62. PubMed ID: 15953349
[TBL] [Abstract][Full Text] [Related]
5. Alzheimer's disease associated presenilin 1 interacts with HC5 and ZETA, subunits of the catalytic 20S proteasome.
Van Gassen G; De Jonghe C; Pype S; Van Criekinge W; Julliams A; Vanderhoeven I; Woodrow S; Beyaert R; Huylebroeck D; Van Broeckhoven C
Neurobiol Dis; 1999 Oct; 6(5):376-91. PubMed ID: 10527805
[TBL] [Abstract][Full Text] [Related]
6. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
Wiley JC; Hudson M; Kanning KC; Schecterson LC; Bothwell M
J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
[TBL] [Abstract][Full Text] [Related]
7. Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?
Knappenberger KS; Tian G; Ye X; Sobotka-Briner C; Ghanekar SV; Greenberg BD; Scott CW
Biochemistry; 2004 May; 43(20):6208-18. PubMed ID: 15147205
[TBL] [Abstract][Full Text] [Related]
8. Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.
Réchards M; Xia W; Oorschot V; van Dijk S; Annaert W; Selkoe DJ; Klumperman J
Traffic; 2006 Mar; 7(3):354-64. PubMed ID: 16497228
[TBL] [Abstract][Full Text] [Related]
9. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex.
Capell A; Grünberg J; Pesold B; Diehlmann A; Citron M; Nixon R; Beyreuther K; Selkoe DJ; Haass C
J Biol Chem; 1998 Feb; 273(6):3205-11. PubMed ID: 9452432
[TBL] [Abstract][Full Text] [Related]
10. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Wolfe MS; Xia W; Ostaszewski BL; Diehl TS; Kimberly WT; Selkoe DJ
Nature; 1999 Apr; 398(6727):513-7. PubMed ID: 10206644
[TBL] [Abstract][Full Text] [Related]
11. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
Walker ES; Martinez M; Brunkan AL; Goate A
J Neurochem; 2005 Jan; 92(2):294-301. PubMed ID: 15663477
[TBL] [Abstract][Full Text] [Related]
12. Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.
Walter J; Grünberg J; Capell A; Pesold B; Schindzielorz A; Citron M; Mendla K; George-Hyslop PS; Multhaup G; Selkoe DJ; Haass C
Proc Natl Acad Sci U S A; 1997 May; 94(10):5349-54. PubMed ID: 9144240
[TBL] [Abstract][Full Text] [Related]
13. Carboxyl-terminal fragments of presenilin-1 are closely related to cytoskeletal abnormalities in Alzheimer's brains.
Tomidokoro Y; Ishiguro K; Igeta Y; Matsubara E; Kanai M; Shizuka M; Kawarabayashi T; Harigaya Y; Kawakatsu S; Ii K; Ikeda M; St George-Hyslop PH; Hirai S; Okamoto K; Shoji M
Biochem Biophys Res Commun; 1999 Mar; 256(3):512-8. PubMed ID: 10080929
[TBL] [Abstract][Full Text] [Related]
14. Presenilins upregulate functional K+ channel currents in mammalian cells.
Malin SA; Guo WX; Jafari G; Goate AM; Nerbonne JM
Neurobiol Dis; 1998 Apr; 4(6):398-409. PubMed ID: 9666479
[TBL] [Abstract][Full Text] [Related]
15. Presenilins and Alzheimer's disease: the role of A beta 42.
Eckman CB
J Neural Transm Suppl; 1998; 53():181-4. PubMed ID: 9700656
[TBL] [Abstract][Full Text] [Related]
16. C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.
Wang J; Beher D; Nyborg AC; Shearman MS; Golde TE; Goate A
J Neurochem; 2006 Jan; 96(1):218-27. PubMed ID: 16305624
[TBL] [Abstract][Full Text] [Related]
17. Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.
Citron M; Eckman CB; Diehl TS; Corcoran C; Ostaszewski BL; Xia W; Levesque G; St George Hyslop P; Younkin SG; Selkoe DJ
Neurobiol Dis; 1998 Aug; 5(2):107-16. PubMed ID: 9746908
[TBL] [Abstract][Full Text] [Related]
18. Amino- and carboxyl-terminal mutants of presenilin 1 cause neuronal cell death through distinct toxic mechanisms: Study of 27 different presenilin 1 mutants.
Hashimoto Y; Tsukamoto E; Niikura T; Yamagishi Y; Ishizaka M; Aiso S; Takashima A; Nishimoto I
J Neurosci Res; 2004 Feb; 75(3):417-28. PubMed ID: 14743455
[TBL] [Abstract][Full Text] [Related]
19. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
Xia W; Ostaszewski BL; Kimberly WT; Rahmati T; Moore CL; Wolfe MS; Selkoe DJ
Neurobiol Dis; 2000 Dec; 7(6 Pt B):673-81. PubMed ID: 11114265
[TBL] [Abstract][Full Text] [Related]
20. Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation.
Steiner H; Capell A; Pesold B; Citron M; Kloetzel PM; Selkoe DJ; Romig H; Mendla K; Haass C
J Biol Chem; 1998 Nov; 273(48):32322-31. PubMed ID: 9822712
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]