These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

373 related articles for article (PubMed ID: 9492383)

  • 21. Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance.
    Brown HS; Griffin M; Houston JB
    Drug Metab Dispos; 2007 Feb; 35(2):293-301. PubMed ID: 17132764
    [TBL] [Abstract][Full Text] [Related]  

  • 22. In vitro hepatic microsomal metabolism of meloxicam in koalas (Phascolarctos cinereus), brushtail possums (Trichosurus vulpecula), ringtail possums (Pseudocheirus peregrinus), rats (Rattus norvegicus) and dogs (Canis lupus familiaris).
    Kimble B; Li KM; Valtchev P; Higgins DP; Krockenberger MB; Govendir M
    Comp Biochem Physiol C Toxicol Pharmacol; 2014 Apr; 161():7-14. PubMed ID: 24345479
    [TBL] [Abstract][Full Text] [Related]  

  • 23. In vitro metabolism of tirilazad mesylate in male and female rats. Contribution of cytochrome P4502C11 and delta 4-5 alpha-reductase.
    Wienkers LC; Steenwyk RC; Mizsak SA; Pearson PG
    Drug Metab Dispos; 1995 Mar; 23(3):383-92. PubMed ID: 7628305
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Kinetics of drug metabolism in rat liver slices. Rates of oxidation of ethoxycoumarin and tolbutamide, examples of high- and low-clearance compounds.
    Worboys PD; Bradbury A; Houston JB
    Drug Metab Dispos; 1995 Mar; 23(3):393-7. PubMed ID: 7628306
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Comparison of fresh and cryopreserved rat hepatocyte suspensions for the prediction of in vitro intrinsic clearance.
    Griffin SJ; Houston JB
    Drug Metab Dispos; 2004 May; 32(5):552-8. PubMed ID: 15100178
    [TBL] [Abstract][Full Text] [Related]  

  • 26. In Vitro-In Vivo Extrapolation and Scaling Factors for Clearance of Human and Preclinical Species with Liver Microsomes and Hepatocytes.
    Tess D; Chang GC; Keefer C; Carlo A; Jones R; Di L
    AAPS J; 2023 Apr; 25(3):40. PubMed ID: 37052732
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Induction of physical dependence by chronic alcohol treatment and enhancement of hepatic metabolism of 7-ethoxycoumarin and subsequent conjugation of its metabolite in perfused rat livers.
    Hong SS; Roh HK; Dong MS; Cha YN
    Arch Int Pharmacodyn Ther; 1987 Feb; 285(2):249-62. PubMed ID: 3579427
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Direct Comparison of Total Clearance Prediction: Computational Machine Learning Model versus Bottom-Up Approach Using In Vitro Assay.
    Kosugi Y; Hosea N
    Mol Pharm; 2020 Jul; 17(7):2299-2309. PubMed ID: 32478525
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: studies of digoxin metabolism in primary rat hepatocytes versus microsomes.
    Lam JL; Benet LZ
    Drug Metab Dispos; 2004 Nov; 32(11):1311-6. PubMed ID: 15483198
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Quantitative Prediction of Human Hepatic Clearance for P450 and Non-P450 Substrates from In Vivo Monkey Pharmacokinetics Study and In Vitro Metabolic Stability Tests Using Hepatocytes.
    Nishimuta H; Watanabe T; Bando K
    AAPS J; 2019 Jan; 21(2):20. PubMed ID: 30673906
    [TBL] [Abstract][Full Text] [Related]  

  • 31. The use of sandwich-cultured rat hepatocytes to determine the intrinsic clearance of compounds with different extraction ratios: 7-ethoxycoumarin and warfarin.
    Treijtel N; van Helvoort H; Barendregt A; Blaauboer BJ; van Eijkeren JC
    Drug Metab Dispos; 2005 Sep; 33(9):1325-32. PubMed ID: 15951450
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Rate-limiting steps in hepatic drug clearance: comparison of hepatocellular uptake and metabolism with microsomal metabolism of saquinavir, nelfinavir, and ritonavir.
    Parker AJ; Houston JB
    Drug Metab Dispos; 2008 Jul; 36(7):1375-84. PubMed ID: 18426953
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor.
    Lin JH; Chiba M; Balani SK; Chen IW; Kwei GY; Vastag KJ; Nishime JA
    Drug Metab Dispos; 1996 Oct; 24(10):1111-20. PubMed ID: 8894513
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Prediction of in vivo rat biliary drug clearance from an in vitro hepatocyte efflux model.
    Lundquist P; Lööf J; Fagerholm U; Sjögren I; Johansson J; Briem S; Hoogstraate J; Afzelius L; Andersson TB
    Drug Metab Dispos; 2014 Mar; 42(3):459-68. PubMed ID: 24396143
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Kinetics of metabolism of deltamethrin and
    Price RJ; Scott MP; Cantrill C; Higgins LG; Moreau M; Yoon M; Clewell HJ; Creek MR; Osimitz TG; Houston JB; Lake BG
    Xenobiotica; 2021 Jan; 51(1):40-50. PubMed ID: 32757971
    [TBL] [Abstract][Full Text] [Related]  

  • 36. An Investigation into the Prediction of in Vivo Clearance for a Range of Flavin-containing Monooxygenase Substrates.
    Jones BC; Srivastava A; Colclough N; Wilson J; Reddy VP; Amberntsson S; Li D
    Drug Metab Dispos; 2017 Oct; 45(10):1060-1067. PubMed ID: 28784689
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans.
    Naritomi Y; Terashita S; Kimura S; Suzuki A; Kagayama A; Sugiyama Y
    Drug Metab Dispos; 2001 Oct; 29(10):1316-24. PubMed ID: 11560875
    [TBL] [Abstract][Full Text] [Related]  

  • 38. In vitro metabolism of benzo[a]pyrene and dibenzo[def,p]chrysene in rodent and human hepatic microsomes.
    Crowell SR; Hanson-Drury S; Williams DE; Corley RA
    Toxicol Lett; 2014 Jul; 228(1):48-55. PubMed ID: 24769260
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction.
    de Graaf IA; de Kanter R; de Jager MH; Camacho R; Langenkamp E; van de Kerkhof EG; Groothuis GM
    Drug Metab Dispos; 2006 Apr; 34(4):591-9. PubMed ID: 16415126
    [TBL] [Abstract][Full Text] [Related]  

  • 40. First-in-Human Predictions of Hepatic Clearance for Drugs With the Well-Stirred Model: Comparative Assessment Between Models of Fraction Unbound Based Either on the Free Drug Hypothesis, Albumin-Facilitated Hepatic Uptake or Dynamic Binding Kinetics.
    Poulin P
    J Pharm Sci; 2024 Aug; 113(8):2641-2650. PubMed ID: 38796154
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 19.