BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

664 related articles for article (PubMed ID: 9521675)

  • 1. Mutagenesis of 3 alpha-hydroxysteroid dehydrogenase reveals a "push-pull" mechanism for proton transfer in aldo-keto reductases.
    Schlegel BP; Jez JM; Penning TM
    Biochemistry; 1998 Mar; 37(10):3538-48. PubMed ID: 9521675
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Retention of NADPH-linked quinone reductase activity in an aldo-keto reductase following mutation of the catalytic tyrosine.
    Schlegel BP; Ratnam K; Penning TM
    Biochemistry; 1998 Aug; 37(31):11003-11. PubMed ID: 9692994
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure and function of 3 alpha-hydroxysteroid dehydrogenase.
    Penning TM; Bennett MJ; Smith-Hoog S; Schlegel BP; Jez JM; Lewis M
    Steroids; 1997 Jan; 62(1):101-11. PubMed ID: 9029723
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Engineering steroid 5 beta-reductase activity into rat liver 3 alpha-hydroxysteroid dehydrogenase.
    Jez JM; Penning TM
    Biochemistry; 1998 Jul; 37(27):9695-703. PubMed ID: 9657682
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The arginine 276 anchor for NADP(H) dictates fluorescence kinetic transients in 3 alpha-hydroxysteroid dehydrogenase, a representative aldo-keto reductase.
    Ratnam K; Ma H; Penning TM
    Biochemistry; 1999 Jun; 38(24):7856-64. PubMed ID: 10387026
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Molecular determinants of steroid recognition and catalysis in aldo-keto reductases. Lessons from 3alpha-hydroxysteroid dehydrogenase.
    Penning TM
    J Steroid Biochem Mol Biol; 1999; 69(1-6):211-25. PubMed ID: 10418995
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Alanine scanning mutagenesis of the testosterone binding site of rat 3 alpha-hydroxysteroid dehydrogenase demonstrates contact residues influence the rate-determining step.
    Heredia VV; Cooper WC; Kruger RG; Jin Y; Penning TM
    Biochemistry; 2004 May; 43(19):5832-41. PubMed ID: 15134457
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Overexpression and mutagenesis of the cDNA for rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase. Role of cysteines and tyrosines in catalysis.
    Pawlowski JE; Penning TM
    J Biol Chem; 1994 May; 269(18):13502-10. PubMed ID: 8175784
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Engineering steroid hormone specificity into aldo-keto reductases.
    Penning TM; Ma H; Jez JM
    Chem Biol Interact; 2001 Jan; 130-132(1-3):659-71. PubMed ID: 11306084
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones.
    Penning TM; Burczynski ME; Jez JM; Hung CF; Lin HK; Ma H; Moore M; Palackal N; Ratnam K
    Biochem J; 2000 Oct; 351(Pt 1):67-77. PubMed ID: 10998348
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Characterization of the substrate binding site in rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase. The roles of tryptophans in ligand binding and protein fluorescence.
    Jez JM; Schlegel BP; Penning TM
    J Biol Chem; 1996 Nov; 271(47):30190-8. PubMed ID: 8939970
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+.
    Bennett MJ; Schlegel BP; Jez JM; Penning TM; Lewis M
    Biochemistry; 1996 Aug; 35(33):10702-11. PubMed ID: 8718859
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Electrostatic stabilization in a pre-organized polar active site: the catalytic role of Lys-80 in Candida tenuis xylose reductase (AKR2B5) probed by site-directed mutagenesis and functional complementation studies.
    Kratzer R; Nidetzky B
    Biochem J; 2005 Jul; 389(Pt 2):507-15. PubMed ID: 15799715
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Effects of buried charged groups on cysteine thiol ionization and reactivity in Escherichia coli thioredoxin: structural and functional characterization of mutants of Asp 26 and Lys 57.
    Dyson HJ; Jeng MF; Tennant LL; Slaby I; Lindell M; Cui DS; Kuprin S; Holmgren A
    Biochemistry; 1997 Mar; 36(9):2622-36. PubMed ID: 9054569
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Dissection of the physiological interconversion of 5alpha-DHT and 3alpha-diol by rat 3alpha-HSD via transient kinetics shows that the chemical step is rate-determining: effect of mutating cofactor and substrate-binding pocket residues on catalysis.
    Heredia VV; Penning TM
    Biochemistry; 2004 Sep; 43(38):12028-37. PubMed ID: 15379543
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mutation of nicotinamide pocket residues in rat liver 3 alpha-hydroxysteroid dehydrogenase reveals different modes of cofactor binding.
    Ma H; Ratnam K; Penning TM
    Biochemistry; 2000 Jan; 39(1):102-9. PubMed ID: 10625484
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.
    Faucher F; Cantin L; Pereira de Jésus-Tran K; Lemieux M; Luu-The V; Labrie F; Breton R
    J Mol Biol; 2007 Jun; 369(2):525-40. PubMed ID: 17442338
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular distribution.
    Lin HK; Jez JM; Schlegel BP; Peehl DM; Pachter JA; Penning TM
    Mol Endocrinol; 1997 Dec; 11(13):1971-84. PubMed ID: 9415401
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure/function aspects of human 3beta-hydroxysteroid dehydrogenase.
    Thomas JL; Duax WL; Addlagatta A; Kacsoh B; Brandt SE; Norris WB
    Mol Cell Endocrinol; 2004 Feb; 215(1-2):73-82. PubMed ID: 15026177
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Serine 124 completes the Tyr, Lys and Ser triad responsible for the catalysis of human type 1 3beta-hydroxysteroid dehydrogenase.
    Thomas JL; Duax WL; Addlagatta A; Scaccia LA; Frizzell KA; Carloni SB
    J Mol Endocrinol; 2004 Aug; 33(1):253-61. PubMed ID: 15291757
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 34.