185 related articles for article (PubMed ID: 9523310)
1. Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers.
Annaert P; Gosselin G; Pompon A; Benzaria S; Valette G; Imbach JL; Naesens L; Hatse S; de Clercq E; Van den Mooter G; Kinget R; Augustijns P
Pharm Res; 1998 Feb; 15(2):239-45. PubMed ID: 9523310
[TBL] [Abstract][Full Text] [Related]
2. Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2).
Annaert P; Kinget R; Naesens L; de Clercq E; Augustijns P
Pharm Res; 1997 Apr; 14(4):492-6. PubMed ID: 9144737
[TBL] [Abstract][Full Text] [Related]
3. Carrier mechanisms involved in the transepithelial transport of bis(POM)-PMEA and its metabolites across Caco-2 monolayers.
Annaert P; Van Gelder J; Naesens L; De Clercq E; Van den Mooter G; Kinget R; Augustijns P
Pharm Res; 1998 Aug; 15(8):1168-73. PubMed ID: 9706045
[TBL] [Abstract][Full Text] [Related]
4. Synthesis, in vitro antiviral evaluation, and stability studies of bis(S-acyl-2-thioethyl) ester derivatives of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) as potential PMEA prodrugs with improved oral bioavailability.
Benzaria S; Pélicano H; Johnson R; Maury G; Imbach JL; Aubertin AM; Obert G; Gosselin G
J Med Chem; 1996 Dec; 39(25):4958-65. PubMed ID: 8960556
[TBL] [Abstract][Full Text] [Related]
5. Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine.
Naesens L; Balzarini J; Bischofberger N; De Clercq E
Antimicrob Agents Chemother; 1996 Jan; 40(1):22-8. PubMed ID: 8787873
[TBL] [Abstract][Full Text] [Related]
6. In vitro, ex vivo, and in situ intestinal absorption characteristics of the antiviral ester prodrug adefovir dipivoxil.
Annaert P; Tukker JJ; van Gelder J; Naesens L; de Clercq E; van Den Mooter G; Kinget R; Augustijns P
J Pharm Sci; 2000 Aug; 89(8):1054-62. PubMed ID: 10906729
[TBL] [Abstract][Full Text] [Related]
7. Synthesis, oral bioavailability determination, and in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).
Starrett JE; Tortolani DR; Russell J; Hitchcock MJ; Whiterock V; Martin JC; Mansuri MM
J Med Chem; 1994 Jun; 37(12):1857-64. PubMed ID: 8021925
[TBL] [Abstract][Full Text] [Related]
8. Pharmacokinetics and metabolism of selected prodrugs of PMEA in rats.
Shaw JP; Louie MS; Krishnamurthy VV; Arimilli MN; Jones RJ; Bidgood AM; Lee WA; Cundy KC
Drug Metab Dispos; 1997 Mar; 25(3):362-6. PubMed ID: 9172955
[TBL] [Abstract][Full Text] [Related]
9. Enhanced 9-(2-phosphonylmethoxyethyl)adenine secretion by a specific, indomethacin-sensitive efflux pump in a mutant 9-(2-phosphonylmethoxyethyl)adenine-resistant human erythroleukemia K562 cell line.
Hatse S; De Clercq E; Balzarini J
Mol Pharmacol; 1998 Nov; 54(5):907-17. PubMed ID: 9804626
[TBL] [Abstract][Full Text] [Related]
10. Oral bioavailability of the antiretroviral agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) from three formulations of the prodrug bis(pivaloyloxymethyl)-PMEA in fasted male cynomolgus monkeys.
Cundy KC; Fishback JA; Shaw JP; Lee ML; Soike KF; Visor GC; Lee WA
Pharm Res; 1994 Jun; 11(6):839-43. PubMed ID: 7937523
[TBL] [Abstract][Full Text] [Related]
11. Inhibition of intestinal metabolism of the antiviral ester prodrug bis(POC)-PMPA by nature-identical fruit extracts as a strategy to enhance its oral absorption: an in vitro study.
Van Gelder J; Annaert P; Naesens L; De Clercq E; Van den Mooter G; Kinget R; Augustijns P
Pharm Res; 1999 Jul; 16(7):1035-40. PubMed ID: 10450927
[TBL] [Abstract][Full Text] [Related]
12. Metabolism and pharmacokinetics of novel oral prodrugs of 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in dogs.
Shaw JP; Sueoko CM; Oliyai R; Lee WA; Arimilli MN; Kim CU; Cundy KC
Pharm Res; 1997 Dec; 14(12):1824-9. PubMed ID: 9453075
[TBL] [Abstract][Full Text] [Related]
13. Novel hepatotrophic prodrugs of the antiviral nucleoside 9-(2-phosphonylmethoxyethyl)adenine with improved pharmacokinetics and antiviral activity.
Biessen EA; Valentijn AR; De Vrueh RL; Van De Bilt E; Sliedregt LA; Prince P; Bijsterbosch MK; Van Boom JH; Van Der Marel GA; Abrahams PJ; Van Berkel TJ
FASEB J; 2000 Sep; 14(12):1784-92. PubMed ID: 10973928
[TBL] [Abstract][Full Text] [Related]
14. Ester prodrugs of acyclic nucleoside thiophosphonates compared to phosphonates: synthesis, antiviral activity and decomposition study.
Roux L; Priet S; Payrot N; Weck C; Fournier M; Zoulim F; Balzarini J; Canard B; Alvarez K
Eur J Med Chem; 2013 May; 63():869-81. PubMed ID: 23603046
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and in vivo evaluation of prodrugs of 9-[2-(phosphonomethoxy)ethoxy]adenine.
Serafinowska HT; Ashton RJ; Bailey S; Harnden MR; Jackson SM; Sutton D
J Med Chem; 1995 Apr; 38(8):1372-9. PubMed ID: 7731022
[TBL] [Abstract][Full Text] [Related]
16. Cytotoxicity of pivoxil esters of antiviral acyclic nucleoside phosphonates: adefovir dipivoxil versus adefovir.
Zídek Z; Kmonícková E; Holý A
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub; 2005 Dec; 149(2):315-9. PubMed ID: 16601779
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine.
Starrett JE; Tortolani DR; Hitchcock MJ; Martin JC; Mansuri MM
Antiviral Res; 1992 Sep; 19(3):267-73. PubMed ID: 1332606
[TBL] [Abstract][Full Text] [Related]
18. Pharmacokinetic and antiretroviral activity in mice of oral [P(1),P(2)-bis[2-(adenin-9-yl)ethoxymethyl]phosphonate], a prodrug of 9-(2-phosphonylmethoxyethyl)adenine.
Rossi L; Dominici S; Serafini S; Casabianca A; Cerasi A; Chiarantini L; Celeste AG; Cappellacci L; Franchetti P; Grifantini M; Magnani M
J Antimicrob Chemother; 2002 Sep; 50(3):365-74. PubMed ID: 12205061
[TBL] [Abstract][Full Text] [Related]
19. Carrier-mediated delivery of 9-(2-phosphonylmethoxyethyl)adenine to parenchymal liver cells: a novel therapeutic approach for hepatitis B.
de Vrueh RL; Rump ET; van De Bilt E; van Veghel R; Balzarini J; Biessen EA; van Berkel TJ; Bijsterbosch MK
Antimicrob Agents Chemother; 2000 Mar; 44(3):477-83. PubMed ID: 10681306
[TBL] [Abstract][Full Text] [Related]
20. Metabolism and in vitro antiretroviral activities of bis(pivaloyloxymethyl) prodrugs of acyclic nucleoside phosphonates.
Srinivas RV; Robbins BL; Connelly MC; Gong YF; Bischofberger N; Fridland A
Antimicrob Agents Chemother; 1993 Oct; 37(10):2247-50. PubMed ID: 8257154
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]