201 related articles for article (PubMed ID: 9524556)
1. Synthesis, topoisomerase I inhibitory activity and in vitro cytotoxicity of camptothecin derivatives bearing five-membered heterocycle containing 10-substituents.
Zhao R; Guan LL; Oreski B; Lown JW
Anticancer Drug Des; 1998 Mar; 13(2):145-57. PubMed ID: 9524556
[TBL] [Abstract][Full Text] [Related]
2. Camptothecin and minor-groove binder hybrid molecules: synthesis, inhibition of topoisomerase I, and anticancer cytotoxicity in vitro.
Zhao R; al-Said NH; Sternbach DL; Lown JW
J Med Chem; 1997 Jan; 40(2):216-25. PubMed ID: 9003520
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and antitumor activity of the hexacyclic camptothecin derivatives.
Gao H; Zhang X; Chen Y; Shen H; Pang T; Sun J; Xu C; Ding J; Li C; Lu W
Bioorg Med Chem Lett; 2005 Jul; 15(13):3233-6. PubMed ID: 15913996
[TBL] [Abstract][Full Text] [Related]
4. Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle.
Moreau P; Anizon F; Sancelme M; Prudhomme M; Bailly C; Carrasco C; Ollier M; Sevère D; Riou JF; Fabbro D; Meyer T; Aubertin AM
J Med Chem; 1998 May; 41(10):1631-40. PubMed ID: 9572888
[TBL] [Abstract][Full Text] [Related]
5. Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.
Jaxel C; Kohn KW; Wani MC; Wall ME; Pommier Y
Cancer Res; 1989 Mar; 49(6):1465-9. PubMed ID: 2538227
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and cytotoxic activity of substituted 7-aryliminomethyl derivatives of camptothecin.
Dallavalle S; Merlini L; Morini G; Musso L; Penco S; Beretta GL; Tinelli S; Zunino F
Eur J Med Chem; 2004 Jun; 39(6):507-13. PubMed ID: 15183909
[TBL] [Abstract][Full Text] [Related]
7. Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.
Fox BM; Xiao X; Antony S; Kohlhagen G; Pommier Y; Staker BL; Stewart L; Cushman M
J Med Chem; 2003 Jul; 46(15):3275-82. PubMed ID: 12852757
[TBL] [Abstract][Full Text] [Related]
8. Novel stable camptothecin derivatives replacing the E-ring lactone by a ketone function are potent inhibitors of topoisomerase I and promising antitumor drugs.
Lansiaux A; Léonce S; Kraus-Berthier L; Bal-Mahieu C; Mazinghien R; Didier S; David-Cordonnier MH; Hautefaye P; Lavielle G; Bailly C; Hickman JA; Pierré A
Mol Pharmacol; 2007 Aug; 72(2):311-9. PubMed ID: 17494837
[TBL] [Abstract][Full Text] [Related]
9. DNA cleavage by topoisomerase I in the presence of indolocarbazole derivatives of rebeccamycin.
Bailly C; Riou JF; Colson P; Houssier C; Rodrigues-Pereira E; Prudhomme M
Biochemistry; 1997 Apr; 36(13):3917-29. PubMed ID: 9092822
[TBL] [Abstract][Full Text] [Related]
10. Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors.
Morrell A; Antony S; Kohlhagen G; Pommier Y; Cushman M
Bioorg Med Chem Lett; 2004 Jul; 14(14):3659-63. PubMed ID: 15203138
[TBL] [Abstract][Full Text] [Related]
11. Molecular modeling studies of the DNA-topoisomerase I ternary cleavable complex with camptothecin.
Fan Y; Weinstein JN; Kohn KW; Shi LM; Pommier Y
J Med Chem; 1998 Jun; 41(13):2216-26. PubMed ID: 9632354
[TBL] [Abstract][Full Text] [Related]
12. Antitumor agents. Part 230: C4'-esters of GL-331 as cytotoxic agents and DNA topoisomerase II inhibitors.
Han S; Xiao Z; Bastow KF; Lee KH
Bioorg Med Chem Lett; 2004 Jun; 14(11):2979-82. PubMed ID: 15125972
[TBL] [Abstract][Full Text] [Related]
13. Homocamptothecins: synthesis and antitumor activity of novel E-ring-modified camptothecin analogues.
Lavergne O; Lesueur-Ginot L; Pla Rodas F; Kasprzyk PG; Pommier J; Demarquay D; Prévost G; Ulibarri G; Rolland A; Schiano-Liberatore AM; Harnett J; Pons D; Camara J; Bigg DC
J Med Chem; 1998 Dec; 41(27):5410-9. PubMed ID: 9876111
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and anticancer activity of simplified indenoisoquinoline topoisomerase I inhibitors lacking substituents on the aromatic rings.
Nagarajan M; Morrell A; Fort BC; Meckley MR; Antony S; Kohlhagen G; Pommier Y; Cushman M
J Med Chem; 2004 Nov; 47(23):5651-61. PubMed ID: 15509164
[TBL] [Abstract][Full Text] [Related]
15. Total and semisynthesis and in vitro studies of both enantiomers of 20-fluorocamptothecin.
Tangirala RS; Dixon R; Yang D; Ambrus A; Antony S; Agama K; Pommier Y; Curran DP
Bioorg Med Chem Lett; 2005 Nov; 15(21):4736-40. PubMed ID: 16140529
[TBL] [Abstract][Full Text] [Related]
16. Water soluble inhibitors of topoisomerase I: quaternary salt derivatives of camptothecin.
Lackey K; Sternbach DD; Croom DK; Emerson DL; Evans MG; Leitner PL; Luzzio MJ; McIntyre G; Vuong A; Yates J; Besterman JM
J Med Chem; 1996 Feb; 39(3):713-9. PubMed ID: 8576914
[TBL] [Abstract][Full Text] [Related]
17. Differential cytotoxic pathways of topoisomerase I and II anticancer agents after overexpression of the E2F-1/DP-1 transcription factor complex.
Hofland K; Petersen BO; Falck J; Helin K; Jensen PB; Sehested M
Clin Cancer Res; 2000 Apr; 6(4):1488-97. PubMed ID: 10778981
[TBL] [Abstract][Full Text] [Related]
18. Inhibition of eukaryotic DNA topoisomerase I and II activities by indoloquinolinedione derivatives.
Riou JF; Helissey P; Grondard L; Giorgi-Renault S
Mol Pharmacol; 1991 Nov; 40(5):699-706. PubMed ID: 1658605
[TBL] [Abstract][Full Text] [Related]
19. Substitution at the F-ring N-imide of the indolocarbazole antitumor drug NB-506 increases the cytotoxicity, DNA binding, and topoisomerase I inhibition activities.
Bailly C; Qu X; Chaires JB; Colson P; Houssier C; Ohkubo M; Nishimura S; Yoshinari T
J Med Chem; 1999 Jul; 42(15):2927-35. PubMed ID: 10425102
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and cytotoxic activity of a new series of topoisomerase I inhibitors.
Dallavalle S; Gattinoni S; Mazzini S; Scaglioni L; Merlini L; Tinelli S; Beretta GL; Zunino F
Bioorg Med Chem Lett; 2008 Feb; 18(4):1484-9. PubMed ID: 18248813
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]