BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

149 related articles for article (PubMed ID: 9539132)

  • 1. An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.
    Davis JA; Naruse S; Chen H; Eckman C; Younkin S; Price DL; Borchelt DR; Sisodia SS; Wong PC
    Neuron; 1998 Mar; 20(3):603-9. PubMed ID: 9539132
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression.
    Qian S; Jiang P; Guan XM; Singh G; Trumbauer ME; Yu H; Chen HY; Van de Ploeg LH; Zheng H
    Neuron; 1998 Mar; 20(3):611-7. PubMed ID: 9539133
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons.
    Berezovska O; Frosch M; McLean P; Knowles R; Koo E; Kang D; Shen J; Lu FM; Lux SE; Tonegawa S; Hyman BT
    Brain Res Mol Brain Res; 1999 Jun; 69(2):273-80. PubMed ID: 10366748
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo.
    Borchelt DR; Thinakaran G; Eckman CB; Lee MK; Davenport F; Ratovitsky T; Prada CM; Kim G; Seekins S; Yager D; Slunt HH; Wang R; Seeger M; Levey AI; Gandy SE; Copeland NG; Jenkins NA; Price DL; Younkin SG; Sisodia SS
    Neuron; 1996 Nov; 17(5):1005-13. PubMed ID: 8938131
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.
    Borchelt DR; Ratovitski T; van Lare J; Lee MK; Gonzales V; Jenkins NA; Copeland NG; Price DL; Sisodia SS
    Neuron; 1997 Oct; 19(4):939-45. PubMed ID: 9354339
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Metabolism of presenilin 1: influence of presenilin 1 on amyloid precursor protein processing.
    Borchelt DR
    Neurobiol Aging; 1998; 19(1 Suppl):S15-8. PubMed ID: 9562461
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm.
    Wong PC; Zheng H; Chen H; Becher MW; Sirinathsinghji DJ; Trumbauer ME; Chen HY; Price DL; Van der Ploeg LH; Sisodia SS
    Nature; 1997 May; 387(6630):288-92. PubMed ID: 9153393
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Hyperaccumulation of FAD-linked presenilin 1 variants in vivo.
    Lee MK; Borchelt DR; Kim G; Thinakaran G; Slunt HH; Ratovitski T; Martin LJ; Kittur A; Gandy S; Levey AI; Jenkins N; Copeland N; Price DL; Sisodia SS
    Nat Med; 1997 Jul; 3(7):756-60. PubMed ID: 9212102
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.
    Cacquevel M; Aeschbach L; Houacine J; Fraering PC
    PLoS One; 2012; 7(4):e35133. PubMed ID: 22529981
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
    Mastrangelo P; Mathews PM; Chishti MA; Schmidt SD; Gu Y; Yang J; Mazzella MJ; Coomaraswamy J; Horne P; Strome B; Pelly H; Levesque G; Ebeling C; Jiang Y; Nixon RA; Rozmahel R; Fraser PE; St George-Hyslop P; Carlson GA; Westaway D
    Proc Natl Acad Sci U S A; 2005 Jun; 102(25):8972-7. PubMed ID: 15951428
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The presenilin 1 C92S mutation increases abeta 42 production.
    Lewis PA; Perez-Tur J; Golde TE; Hardy J
    Biochem Biophys Res Commun; 2000 Oct; 277(1):261-3. PubMed ID: 11027672
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Expression of a familial Alzheimer's disease-linked presenilin-1 variant enhances perforant pathway lesion-induced neuronal loss in the entorhinal cortex.
    Lazarov O; Peterson LD; Peterson DA; Sisodia SS
    J Neurosci; 2006 Jan; 26(2):429-34. PubMed ID: 16407539
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice.
    Wen PH; Hof PR; Chen X; Gluck K; Austin G; Younkin SG; Younkin LH; DeGasperi R; Gama Sosa MA; Robakis NK; Haroutunian V; Elder GA
    Exp Neurol; 2004 Aug; 188(2):224-37. PubMed ID: 15246822
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
    Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ
    Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Implications of presenilin 1 mutations in Alzheimer's disease.
    Komano H; Sudoh S; Kawamura Y; Wang R; Yanagisawa K
    Mech Ageing Dev; 1999 Mar; 107(3):281-98. PubMed ID: 10360683
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing.
    Baumeister R; Leimer U; Zweckbronner I; Jakubek C; Grünberg J; Haass C
    Genes Funct; 1997 Apr; 1(2):149-59. PubMed ID: 9680315
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Deficits in Enrichment-Dependent Neurogenesis and Enhanced Anxiety Behaviors Mediated by Expression of Alzheimer's Disease-Linked Ps1 Variants Are Rescued by Microglial Depletion.
    Ortega-Martinez S; Palla N; Zhang X; Lipman E; Sisodia SS
    J Neurosci; 2019 Aug; 39(34):6766-6780. PubMed ID: 31217332
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
    Walker ES; Martinez M; Brunkan AL; Goate A
    J Neurochem; 2005 Jan; 92(2):294-301. PubMed ID: 15663477
    [TBL] [Abstract][Full Text] [Related]  

  • 19. [Molecular cell biology of presenilins].
    Tomita T; Iwatsubo T
    Nihon Yakurigaku Zasshi; 1999 Dec; 114(6):337-46. PubMed ID: 10672594
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease.
    Murayama O; Tomita T; Nihonmatsu N; Murayama M; Sun X; Honda T; Iwatsubo T; Takashima A
    Neurosci Lett; 1999 Apr; 265(1):61-3. PubMed ID: 10327206
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.