90 related articles for article (PubMed ID: 9548808)
1. Synthesis and DNA reactivity of alpha-hydroxylated metabolites of nonsteroidal antiestrogens.
Hardcastle IR; Horton MN; Osborne MR; Hewer A; Jarman M; Phillips DH
Chem Res Toxicol; 1998 Apr; 11(4):369-74. PubMed ID: 9548808
[TBL] [Abstract][Full Text] [Related]
2. Oxo substituents markedly alter the phase II metabolism of alpha-hydroxybutenylbenzenes: models probing the bioactivation mechanisms of tamoxifen.
Ramakrishna KV; Fan PW; Boyer CS; Dalvie D; Bolton JL
Chem Res Toxicol; 1997 Aug; 10(8):887-94. PubMed ID: 9282838
[TBL] [Abstract][Full Text] [Related]
3. Idoxifene derivatives are less reactive to DNA than tamoxifen derivatives, both chemically and in human and rat liver cells.
Osborne MR; Hewer A; Davis W; Strain AJ; Keogh A; Hardcastle IR; Phillips DH
Carcinogenesis; 1999 Feb; 20(2):293-7. PubMed ID: 10069467
[TBL] [Abstract][Full Text] [Related]
4. 4-Hydroxytamoxifen gives DNA adducts by chemical activation, but not in rat liver cells.
Osborne MR; Davis W; Hewer AJ; Hardcastle IR; Phillips DH
Chem Res Toxicol; 1999 Feb; 12(2):151-8. PubMed ID: 10027792
[TBL] [Abstract][Full Text] [Related]
5. Conformational studies and electronic structures of tamoxifen and toremifene and their allylic carbocations proposed as reactive intermediates leading to DNA adduct formation.
Kuramochi H
J Med Chem; 1996 Jul; 39(15):2877-86. PubMed ID: 8709121
[TBL] [Abstract][Full Text] [Related]
6. Stereoselective metabolic activation of alpha-hydroxy-N-desmethyltamoxifen: the R-isomer forms more DNA adducts in rat liver cells.
Osborne MR; Hewer A; Phillips DH
Chem Res Toxicol; 2004 May; 17(5):697-701. PubMed ID: 15144227
[TBL] [Abstract][Full Text] [Related]
7. Identification of tamoxifen-DNA adducts formed by alpha-sulfate tamoxifen and alpha-acetoxytamoxifen.
Dasaradhi L; Shibutani S
Chem Res Toxicol; 1997 Feb; 10(2):189-96. PubMed ID: 9049430
[TBL] [Abstract][Full Text] [Related]
8. Determination of tamoxifen--DNA adducts in leukocytes from breast cancer patients treated with tamoxifen.
Umemoto A; Monden Y; Lin CX; Abdul-Momen M; Ueyama Y; Komaki K; Laxmi YR; Shibutani S
Chem Res Toxicol; 2004 Dec; 17(12):1577-83. PubMed ID: 15606132
[TBL] [Abstract][Full Text] [Related]
9. Synthesis, biochemical properties and molecular modelling studies of organometallic specific estrogen receptor modulators (SERMs), the ferrocifens and hydroxyferrocifens: evidence for an antiproliferative effect of hydroxyferrocifens on both hormone-dependent and hormone-independent breast cancer cell lines.
Top S; Vessières A; Leclercq G; Quivy J; Tang J; Vaissermann J; Huché M; Jaouen G
Chemistry; 2003 Nov; 9(21):5223-36. PubMed ID: 14613131
[TBL] [Abstract][Full Text] [Related]
10. Organ specificity of DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen in the rat: implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessment.
Phillips DH; Hewer A; Osborne MR; Cole KJ; Churchill C; Arlt VM
Mutagenesis; 2005 Jul; 20(4):297-303. PubMed ID: 15928012
[TBL] [Abstract][Full Text] [Related]
11. Lack of genotoxicity of tamoxifen in human endometrium.
Carmichael PL; Ugwumadu AH; Neven P; Hewer AJ; Poon GK; Phillips DH
Cancer Res; 1996 Apr; 56(7):1475-9. PubMed ID: 8603387
[TBL] [Abstract][Full Text] [Related]
12. Tamoxifen-DNA adducts formed by alpha-acetoxytamoxifen N-oxide.
Umemoto A; Monden Y; Komaki K; Suwa M; Kanno Y; Suzuki M; Lin CX; Ueyama Y; Momen MA; Ravindernath A; Shibutani S
Chem Res Toxicol; 1999 Nov; 12(11):1083-9. PubMed ID: 10563834
[TBL] [Abstract][Full Text] [Related]
13. Quantification of tamoxifen DNA adducts using on-line sample preparation and HPLC-electrospray ionization tandem mass spectrometry.
Gamboa da Costa G; Marques MM; Beland FA; Freeman JP; Churchwell MI; Doerge DR
Chem Res Toxicol; 2003 Mar; 16(3):357-66. PubMed ID: 12641436
[TBL] [Abstract][Full Text] [Related]
14. Determination of DNA damage in F344 rats induced by geometric isomers of tamoxifen and analogues.
Brown K; Brown JE; Martin EA; Smith LL; White IN
Chem Res Toxicol; 1998 May; 11(5):527-34. PubMed ID: 9585484
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and investigation of alpha-hydroxy-N,N-didesmethyltamoxifen as a proximate carcinogen in the metabolic activation of tamoxifen.
Gamboa da Costa G; Marques MM; Freeman JP; Beland FA
Chem Res Toxicol; 2003 Sep; 16(9):1090-8. PubMed ID: 12971796
[TBL] [Abstract][Full Text] [Related]
16. Tamoxifen metabolism in rat liver microsomes: identification of a dimeric metabolite derived from free radical intermediates by liquid chromatography/mass spectrometry.
Jones RM; Yuan ZX; Lim CK
Rapid Commun Mass Spectrom; 1999; 13(4):211-5. PubMed ID: 10097399
[TBL] [Abstract][Full Text] [Related]
17. Formation of tamoxifen-DNA adducts in human endometrial explants exposed to alpha-hydroxytamoxifen.
Kim SY; Suzuki N; Laxmi YR; McGarrigle BP; Olson JR; Sharma M; Sharma M; Shibutani S
Chem Res Toxicol; 2005 May; 18(5):889-95. PubMed ID: 15892583
[TBL] [Abstract][Full Text] [Related]
18. Resolution of alpha-hydroxytamoxifen; R-isomer forms more DNA adducts in rat liver cells.
Osborne MR; Hewer A; Phillips DH
Chem Res Toxicol; 2001 Jul; 14(7):888-93. PubMed ID: 11453736
[TBL] [Abstract][Full Text] [Related]
19. Effect of N,N-didesmethyltamoxifen upon DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen.
Gamboa da Costa G; Marques MM; Fu X; Churchwell MI; Wang YP; Doerge DR; Beland FA
Cancer Lett; 2007 Nov; 257(2):191-8. PubMed ID: 17765393
[TBL] [Abstract][Full Text] [Related]
20. alpha-Hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity in rat hepatocytes.
Phillips DH; Carmichael PL; Hewer A; Cole KJ; Poon GK
Cancer Res; 1994 Nov; 54(21):5518-22. PubMed ID: 7923188
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
