391 related articles for article (PubMed ID: 9554874)
1. Synthesis and biological activities of tricyclic conformationally restricted tetrahydropyrido annulated furo[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases.
Gangjee A; Elzein E; Queener SF; McGuire JJ
J Med Chem; 1998 Apr; 41(9):1409-16. PubMed ID: 9554874
[TBL] [Abstract][Full Text] [Related]
2. 2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases.
Gangjee A; Vasudevan A; Queener SF; Kisliuk RL
J Med Chem; 1996 Mar; 39(7):1438-46. PubMed ID: 8691474
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents.
Gangjee A; Adair OO; Queener SF
J Med Chem; 2003 Nov; 46(23):5074-82. PubMed ID: 14584957
[TBL] [Abstract][Full Text] [Related]
4. New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity.
Rosowsky A; Forsch RA; Sibley CH; Inderlied CB; Queener SF
J Med Chem; 2004 Mar; 47(6):1475-86. PubMed ID: 14998335
[TBL] [Abstract][Full Text] [Related]
5. Selective Pneumocystis carinii dihydrofolate reductase inhibitors: design, synthesis, and biological evaluation of new 2,4-diamino-5-substituted-furo[2,3-d]pyrimidines.
Gangjee A; Guo X; Queener SF; Cody V; Galitsky N; Luft JR; Pangborn W
J Med Chem; 1998 Apr; 41(8):1263-71. PubMed ID: 9548816
[TBL] [Abstract][Full Text] [Related]
6. Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents.
Gangjee A; Vidwans AP; Vasudevan A; Queener SF; Kisliuk RL; Cody V; Li R; Galitsky N; Luft JR; Pangborn W
J Med Chem; 1998 Aug; 41(18):3426-34. PubMed ID: 9719595
[TBL] [Abstract][Full Text] [Related]
7. Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase inhibitors and antitumor agents: synthesis and biological activities of 2,4-diamino-5-methyl-6-[(monosubstituted anilino)methyl] pyrido[2,3-d]pyrimidines.
Gangjee A; Adair O; Queener SF
J Med Chem; 1999 Jul; 42(13):2447-55. PubMed ID: 10395486
[TBL] [Abstract][Full Text] [Related]
8. Synthesis and biological activities of conformationally restricted, tricyclic nonclassical antifolates as inhibitors of dihydrofolate reductases.
Gangjee A; Shi J; Queener SF
J Med Chem; 1997 Jun; 40(12):1930-6. PubMed ID: 9191971
[TBL] [Abstract][Full Text] [Related]
9. Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.
Robson C; Meek MA; Grunwaldt JD; Lambert PA; Queener SF; Schmidt D; Griffin RJ
J Med Chem; 1997 Sep; 40(19):3040-8. PubMed ID: 9301666
[TBL] [Abstract][Full Text] [Related]
10. Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three major opportunistic pathogens of AIDS.
Rosowsky A; Forsch RA; Queener SF
J Med Chem; 2003 Apr; 46(9):1726-36. PubMed ID: 12699390
[TBL] [Abstract][Full Text] [Related]
11. 2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors.
Gangjee A; Jain HD; Phan J; Guo X; Queener SF; Kisliuk RL
Bioorg Med Chem; 2010 Jan; 18(2):953-61. PubMed ID: 20056546
[TBL] [Abstract][Full Text] [Related]
12. Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents.
Gangjee A; Lin X; Kisliuk RL; McGuire JJ
J Med Chem; 2005 Nov; 48(23):7215-22. PubMed ID: 16279780
[TBL] [Abstract][Full Text] [Related]
13. 6-Substituted 2,4-diaminopyrido[3,2-d]pyrimidine analogues of piritrexim as inhibitors of dihydrofolate reductase from rat liver, Pneumocystis carinii, and Toxoplasma gondii and as antitumor agents.
Gangjee A; Zhu Y; Queener SF
J Med Chem; 1998 Nov; 41(23):4533-41. PubMed ID: 9804692
[TBL] [Abstract][Full Text] [Related]
14. Design, synthesis, and antifolate activity of new analogues of piritrexim and other diaminopyrimidine dihydrofolate reductase inhibitors with omega-carboxyalkoxy or omega-carboxy-1-alkynyl substitution in the side chain.
Chan DC; Fu H; Forsch RA; Queener SF; Rosowsky A
J Med Chem; 2005 Jun; 48(13):4420-31. PubMed ID: 15974594
[TBL] [Abstract][Full Text] [Related]
15. Effect of N9-methylation and bridge atom variation on the activity of 5-substituted 2,4-diaminopyrrolo[2,3-d]pyrimidines against dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii.
Gangjee A; Mavandadi F; Queener SF
J Med Chem; 1997 Mar; 40(7):1173-7. PubMed ID: 9089339
[TBL] [Abstract][Full Text] [Related]
16. Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver, Pneumocystis carinii, and Toxoplasma gondii.
Gangjee A; Zhu Y; Queener SF; Francom P; Broom AD
J Med Chem; 1996 Apr; 39(9):1836-45. PubMed ID: 8627607
[TBL] [Abstract][Full Text] [Related]
17. Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reductases and as potential antipneumocystis, antitoxoplasma, and antitumor agents.
Gangjee A; Shi J; Queener SF; Barrows LR; Kisliuk RL
J Med Chem; 1993 Oct; 36(22):3437-43. PubMed ID: 8230134
[TBL] [Abstract][Full Text] [Related]
18. Conformationally restricted analogues of trimethoprim: 2,6-diamino-8-substituted purines as potential dihydrofolate reductase inhibitors from Pneumocystis carinii and Toxoplasma gondii.
Gangjee A; Vasudevan A; Queener SF
J Med Chem; 1997 Sep; 40(19):3032-9. PubMed ID: 9301665
[TBL] [Abstract][Full Text] [Related]
19. Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductases by 2,4-diamino-5-[2-methoxy-5-(omega-carboxyalkyloxy)benzyl]pyrimidines: marked improvement in potency relative to trimethoprim and species selectivity relative to piritrexim.
Rosowsky A; Forsch RA; Queener SF
J Med Chem; 2002 Jan; 45(1):233-41. PubMed ID: 11754594
[TBL] [Abstract][Full Text] [Related]
20. Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent.
Gangjee A; Yu J; McGuire JJ; Cody V; Galitsky N; Kisliuk RL; Queener SF
J Med Chem; 2000 Oct; 43(21):3837-51. PubMed ID: 11052789
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]