These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
95 related articles for article (PubMed ID: 9572881)
1. Potent, selective, and orally bioavailable tricyclic pyridyl acetamide N-oxide inhibitors of farnesyl protein transferase with enhanced in vivo antitumor activity. Njoroge FG; Vibulbhan B; Pinto P; Bishop WR; Bryant MS; Nomeir AA; Lin C; Liu M; Doll RJ; Girijavallabhan V; Ganguly AK J Med Chem; 1998 May; 41(10):1561-7. PubMed ID: 9572881 [TBL] [Abstract][Full Text] [Related]
2. Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene )- piperidine inhibitors of farnesyl-protein transferase: design and synthesis of in vivo active antitumor compounds. Njoroge FG; Vibulbhan B; Rane DF; Bishop WR; Petrin J; Patton R; Bryant MS; Chen KJ; Nomeir AA; Lin CC; Liu M; King I; Chen J; Lee S; Yaremko B; Dell J; Lipari P; Malkowski M; Li Z; Catino J; Doll RJ; Girijavallabhan V; Ganguly AK J Med Chem; 1997 Dec; 40(26):4290-301. PubMed ID: 9435898 [TBL] [Abstract][Full Text] [Related]
3. Inhibitors of farnesyl protein transferase. 4-Amido, 4-carbamoyl, and 4-carboxamido derivatives of 1-(8-chloro-6,11-dihydro-5H-benzo[5,6]- cyclohepta[1,2-b]pyridin-11-yl)piperazine and 1-(3-bromo-8-chloro-6,11- dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine. Mallams AK; Rossman RR; Doll RJ; Girijavallabhan VM; Ganguly AK; Petrin J; Wang L; Patton R; Bishop WR; Carr DM; Kirschmeier P; Catino JJ; Bryant MS; Chen KJ; Korfmacher WA; Nardo C; Wang S; Nomeir AA; Lin CC; Li Z; Chen J; Lee S; Dell J; Lipari P; Liu M J Med Chem; 1998 Mar; 41(6):877-93. PubMed ID: 9526562 [TBL] [Abstract][Full Text] [Related]
4. Effects of SCH 59228, an orally bioavailable farnesyl protein transferase inhibitor, on the growth of oncogene-transformed fibroblasts and a human colon carcinoma xenograft in nude mice. Liu M; Bryant MS; Chen J; Lee S; Yaremko B; Li Z; Dell J; Lipari P; Malkowski M; Prioli N; Rossman RR; Korfmacher WA; Nomeir AA; Lin CC; Mallams AK; Doll RJ; Catino JJ; Girijavallabhan VM; Kirschmeier P; Bishop WR Cancer Chemother Pharmacol; 1999; 43(1):50-8. PubMed ID: 9923541 [TBL] [Abstract][Full Text] [Related]
5. Design and in vivo analysis of potent non-thiol inhibitors of farnesyl protein transferase. Anthony NJ; Gomez RP; Schaber MD; Mosser SD; Hamilton KA; O'Neil TJ; Koblan KS; Graham SL; Hartman GD; Shah D; Rands E; Kohl NE; Gibbs JB; Oliff AI J Med Chem; 1999 Aug; 42(17):3356-68. PubMed ID: 10464022 [TBL] [Abstract][Full Text] [Related]
6. Bridgehead modification of trihalocycloheptabenzopyridine leads to a potent farnesyl protein transferase inhibitor with improved oral metabolic stability. Njoroge FG; Vibulbhan B; Shi X; Strickland C; Kirschmeier P; Bishop R; Nomeir A; Girijavallabhan V Bioorg Med Chem Lett; 2004 Dec; 14(23):5899-902. PubMed ID: 15501065 [TBL] [Abstract][Full Text] [Related]
7. [Anti tumor activity of farnesyl transferase inhibitor]. Yoshimatsu K; Nagasu T Gan To Kagaku Ryoho; 1997 Jan; 24(2):145-55. PubMed ID: 9030225 [TBL] [Abstract][Full Text] [Related]
8. (+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5, 6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamid e (SCH-66336): a very potent farnesyl protein transferase inhibitor as a novel antitumor agent. Njoroge FG; Taveras AG; Kelly J; Remiszewski S; Mallams AK; Wolin R; Afonso A; Cooper AB; Rane DF; Liu YT; Wong J; Vibulbhan B; Pinto P; Deskus J; Alvarez CS; del Rosario J; Connolly M; Wang J; Desai J; Rossman RR; Bishop WR; Patton R; Wang L; Kirschmeier P; Ganguly AK J Med Chem; 1998 Nov; 41(24):4890-902. PubMed ID: 9822558 [TBL] [Abstract][Full Text] [Related]
9. Antitumor activity of orally bioavailable farnesyltransferase inhibitor, ABT-100, is mediated by antiproliferative, proapoptotic, and antiangiogenic effects in xenograft models. Ferguson D; Rodriguez LE; Palma JP; Refici M; Jarvis K; O'Connor J; Sullivan GM; Frost D; Marsh K; Bauch J; Zhang H; Lin NH; Rosenberg S; Sham HL; Joseph IB Clin Cancer Res; 2005 Apr; 11(8):3045-54. PubMed ID: 15837760 [TBL] [Abstract][Full Text] [Related]
10. Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models. Lobell RB; Omer CA; Abrams MT; Bhimnathwala HG; Brucker MJ; Buser CA; Davide JP; deSolms SJ; Dinsmore CJ; Ellis-Hutchings MS; Kral AM; Liu D; Lumma WC; Machotka SV; Rands E; Williams TM; Graham SL; Hartman GD; Oliff AI; Heimbrook DC; Kohl NE Cancer Res; 2001 Dec; 61(24):8758-68. PubMed ID: 11751396 [TBL] [Abstract][Full Text] [Related]
11. Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity. Leftheris K; Kline T; Vite GD; Cho YH; Bhide RS; Patel DV; Patel MM; Schmidt RJ; Weller HN; Andahazy ML; Carboni JM; Gullo-Brown JL; Lee FY; Ricca C; Rose WC; Yan N; Barbacid M; Hunt JT; Meyers CA; Seizinger BR; Zahler R; Manne V J Med Chem; 1996 Jan; 39(1):224-36. PubMed ID: 8568812 [TBL] [Abstract][Full Text] [Related]
12. Second-generation peptidomimetic inhibitors of protein farnesyltransferase demonstrating improved cellular potency and significant in vivo efficacy. O'Connor SJ; Barr KJ; Wang L; Sorensen BK; Tasker AS; Sham H; Ng SC; Cohen J; Devine E; Cherian S; Saeed B; Zhang H; Lee JY; Warner R; Tahir S; Kovar P; Ewing P; Alder J; Mitten M; Leal J; Marsh K; Bauch J; Hoffman DJ; Sebti SM; Rosenberg SH J Med Chem; 1999 Sep; 42(18):3701-10. PubMed ID: 10479301 [TBL] [Abstract][Full Text] [Related]
13. Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity. Kasibhatla SR; Hong K; Biamonte MA; Busch DJ; Karjian PL; Sensintaffar JL; Kamal A; Lough RE; Brekken J; Lundgren K; Grecko R; Timony GA; Ran Y; Mansfield R; Fritz LC; Ulm E; Burrows FJ; Boehm MF J Med Chem; 2007 Jun; 50(12):2767-78. PubMed ID: 17488003 [TBL] [Abstract][Full Text] [Related]
14. Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice. Liu M; Bryant MS; Chen J; Lee S; Yaremko B; Lipari P; Malkowski M; Ferrari E; Nielsen L; Prioli N; Dell J; Sinha D; Syed J; Korfmacher WA; Nomeir AA; Lin CC; Wang L; Taveras AG; Doll RJ; Njoroge FG; Mallams AK; Remiszewski S; Catino JJ; Girijavallabhan VM; Bishop WR Cancer Res; 1998 Nov; 58(21):4947-56. PubMed ID: 9810004 [TBL] [Abstract][Full Text] [Related]
15. C-terminal modifications of histidyl-N-benzylglycinamides to give improved inhibition of Ras farnesyltransferase, cellular activity, and anticancer activity in mice. McNamara DJ; Dobrusin E; Leonard DM; Shuler KR; Kaltenbronn JS; Quin J; Bur S; Thomas CE; Doherty AM; Scholten JD; Zimmerman KK; Gibbs BS; Gowan RC; Latash MP; Leopold WR; Przybranowski SA; Sebolt-Leopold JS J Med Chem; 1997 Oct; 40(21):3319-22. PubMed ID: 9341905 [No Abstract] [Full Text] [Related]
16. CEP-7055: a novel, orally active pan inhibitor of vascular endothelial growth factor receptor tyrosine kinases with potent antiangiogenic activity and antitumor efficacy in preclinical models. Ruggeri B; Singh J; Gingrich D; Angeles T; Albom M; Yang S; Chang H; Robinson C; Hunter K; Dobrzanski P; Jones-Bolin S; Pritchard S; Aimone L; Klein-Szanto A; Herbert JM; Bono F; Schaeffer P; Casellas P; Bourie B; Pili R; Isaacs J; Ator M; Hudkins R; Vaught J; Mallamo J; Dionne C Cancer Res; 2003 Sep; 63(18):5978-91. PubMed ID: 14522925 [TBL] [Abstract][Full Text] [Related]
17. Identification of pharmacokinetically stable 3, 10-dibromo-8-chlorobenzocycloheptapyridine farnesyl protein transferase inhibitors with potent enzyme and cellular activities. Taveras AG; Deskus J; Chao J; Vaccaro CJ; Njoroge FG; Vibulbhan B; Pinto P; Remiszewski S; del Rosario J; Doll RJ; Alvarez C; Lalwani T; Mallams AK; Rossman RR; Afonso A; Girijavallabhan VM; Ganguly AK; Pramanik B; Heimark L; Bishop WR; Wang L; Kirschmeier P; James L; Carr D; Liu M J Med Chem; 1999 Jul; 42(14):2651-61. PubMed ID: 10411485 [TBL] [Abstract][Full Text] [Related]
18. Atropisomeric trihalobenzocycloheptapyridine analogues provide stereoselective FPT inhibitors with antitumor activity. Njoroge FG; Vibulbhan B; Bishop WR; Kirschmeier P; Bryant MS; Nomeir AA; Liu M; Doll RJ; Girijavallabhan VM; Ganguly AK Bioorg Med Chem; 1999 May; 7(5):861-7. PubMed ID: 10400339 [TBL] [Abstract][Full Text] [Related]
19. Design, synthesis, and structure-activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors. Lombardo LJ; Camuso A; Clark J; Fager K; Gullo-Brown J; Hunt JT; Inigo I; Kan D; Koplowitz B; Lee F; McGlinchey K; Qian L; Ricca C; Rovnyak G; Traeger S; Tokarski J; Williams DK; Wu LI; Zhao Y; Manne V; Bhide RS Bioorg Med Chem Lett; 2005 Apr; 15(7):1895-9. PubMed ID: 15780629 [TBL] [Abstract][Full Text] [Related]
20. Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor. Cee VJ; Schenkel LB; Hodous BL; Deak HL; Nguyen HN; Olivieri PR; Romero K; Bak A; Be X; Bellon S; Bush TL; Cheng AC; Chung G; Coats S; Eden PM; Hanestad K; Gallant PL; Gu Y; Huang X; Kendall RL; Lin MH; Morrison MJ; Patel VF; Radinsky R; Rose PE; Ross S; Sun JR; Tang J; Zhao H; Payton M; Geuns-Meyer SD J Med Chem; 2010 Sep; 53(17):6368-77. PubMed ID: 20684549 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]