167 related articles for article (PubMed ID: 9575206)
1. Genetic and biochemical studies establish that the fungicidal effect of a fully depeptidized inhibitor of Cryptococcus neoformans myristoyl-CoA:protein N-myristoyltransferase (Nmt) is Nmt-dependent.
Lodge JK; Jackson-Machelski E; Higgins M; McWherter CA; Sikorski JA; Devadas B; Gordon JI
J Biol Chem; 1998 May; 273(20):12482-91. PubMed ID: 9575206
[TBL] [Abstract][Full Text] [Related]
2. N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase.
Lodge JK; Jackson-Machelski E; Devadas B; Zupec ME; Getman DP; Kishore N; Freeman SK; McWherter CA; Sikorski JA; Gordon JI
Microbiology (Reading); 1997 Feb; 143 ( Pt 2)():357-366. PubMed ID: 9043113
[TBL] [Abstract][Full Text] [Related]
3. Comparison of myristoyl-CoA:protein N-myristoyltransferases from three pathogenic fungi: Cryptococcus neoformans, Histoplasma capsulatum, and Candida albicans.
Lodge JK; Johnson RL; Weinberg RA; Gordon JI
J Biol Chem; 1994 Jan; 269(4):2996-3009. PubMed ID: 8300631
[TBL] [Abstract][Full Text] [Related]
4. Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity.
Devadas B; Freeman SK; Zupec ME; Lu HF; Nagarajan SR; Kishore NS; Lodge JK; Kuneman DW; McWherter CA; Vinjamoori DV; Getman DP; Gordon JI; Sikorski JA
J Med Chem; 1997 Aug; 40(16):2609-25. PubMed ID: 9258368
[TBL] [Abstract][Full Text] [Related]
5. Scanning alanine mutagenesis and de-peptidization of a Candida albicans myristoyl-CoA:protein N-myristoyltransferase octapeptide substrate reveals three elements critical for molecular recognition.
McWherter CA; Rocque WJ; Zupec ME; Freeman SK; Brown DL; Devadas B; Getman DP; Sikorski JA; Gordon JI
J Biol Chem; 1997 May; 272(18):11874-80. PubMed ID: 9115247
[TBL] [Abstract][Full Text] [Related]
6. Targeted gene replacement demonstrates that myristoyl-CoA: protein N-myristoyltransferase is essential for viability of Cryptococcus neoformans.
Lodge JK; Jackson-Machelski E; Toffaletti DL; Perfect JR; Gordon JI
Proc Natl Acad Sci U S A; 1994 Dec; 91(25):12008-12. PubMed ID: 7991574
[TBL] [Abstract][Full Text] [Related]
7. Selective peptidic and peptidomimetic inhibitors of Candida albicans myristoylCoA: protein N-myristoyltransferase: a new approach to antifungal therapy.
Sikorski JA; Devadas B; Zupec ME; Freeman SK; Brown DL; Lu HF; Nagarajan S; Mehta PP; Wade AC; Kishore NS; Bryant ML; Getman DP; McWherter CA; Gordon JI
Biopolymers; 1997; 43(1):43-71. PubMed ID: 9174411
[TBL] [Abstract][Full Text] [Related]
8. Molecular cloning and biochemical characterization of bovine spleen myristoyl CoA:protein N-myristoyltransferase.
Raju RV; Anderson JW; Datla RS; Sharma RK
Arch Biochem Biophys; 1997 Dec; 348(1):134-42. PubMed ID: 9390183
[TBL] [Abstract][Full Text] [Related]
9. Synthesis of myristoyl CoA analogues and myristoyl peptides as inhibitors of myristoyl CoA:protein N-myristoyltransferase.
Zheng GQ; Hu X; Cassady JM; Paige LA; Geahlen RL
J Pharm Sci; 1994 Feb; 83(2):233-8. PubMed ID: 8169796
[TBL] [Abstract][Full Text] [Related]
10. Characterization and selective inhibition of myristoyl-CoA:protein N-myristoyltransferase from Trypanosoma brucei and Leishmania major.
Panethymitaki C; Bowyer PW; Price HP; Leatherbarrow RJ; Brown KA; Smith DF
Biochem J; 2006 Jun; 396(2):277-85. PubMed ID: 16480339
[TBL] [Abstract][Full Text] [Related]
11. Studies of the catalytic activities and substrate specificities of Saccharomyces cerevisiae myristoyl-coenzyme A: protein N-myristoyltransferase deletion mutants and human/yeast Nmt chimeras in Escherichia coli and S. cerevisiae.
Rudnick DA; Johnson RL; Gordon JI
J Biol Chem; 1992 Nov; 267(33):23852-61. PubMed ID: 1429724
[TBL] [Abstract][Full Text] [Related]
12. Metabolic activation of 2-substituted derivatives of myristic acid to form potent inhibitors of myristoyl CoA:protein N-myristoyltransferase.
Paige LA; Zheng GQ; DeFrees SA; Cassady JM; Geahlen RL
Biochemistry; 1990 Nov; 29(46):10566-73. PubMed ID: 2271666
[TBL] [Abstract][Full Text] [Related]
13. Mutations of human myristoyl-CoA:protein N-myristoyltransferase cause temperature-sensitive myristic acid auxotrophy in Saccharomyces cerevisiae.
Duronio RJ; Reed SI; Gordon JI
Proc Natl Acad Sci U S A; 1992 May; 89(9):4129-33. PubMed ID: 1570339
[TBL] [Abstract][Full Text] [Related]
14. The substrate specificity of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase. Analysis of myristic acid analogs containing oxygen, sulfur, double bonds, triple bonds, and/or an aromatic residue.
Kishore NS; Lu TB; Knoll LJ; Katoh A; Rudnick DA; Mehta PP; Devadas B; Huhn M; Atwood JL; Adams SP
J Biol Chem; 1991 May; 266(14):8835-55. PubMed ID: 2026598
[TBL] [Abstract][Full Text] [Related]
15. 4-oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus I.
Langner CA; Lodge JK; Travis SJ; Caldwell JE; Lu T; Li Q; Bryant ML; Devadas B; Gokel GW; Kobayashi GS
J Biol Chem; 1992 Aug; 267(24):17159-69. PubMed ID: 1512254
[TBL] [Abstract][Full Text] [Related]
16. Myristic acid auxotrophy caused by mutation of S. cerevisiae myristoyl-CoA:protein N-myristoyltransferase.
Duronio RJ; Rudnick DA; Johnson RL; Johnson DR; Gordon JI
J Cell Biol; 1991 Jun; 113(6):1313-30. PubMed ID: 2045414
[TBL] [Abstract][Full Text] [Related]
17. Genetic studies reveal that myristoylCoA:protein N-myristoyltransferase is an essential enzyme in Candida albicans.
Weinberg RA; McWherter CA; Freeman SK; Wood DC; Gordon JI; Lee SC
Mol Microbiol; 1995 Apr; 16(2):241-50. PubMed ID: 7565086
[TBL] [Abstract][Full Text] [Related]
18. Protein N-myristoylation in Escherichia coli: reconstitution of a eukaryotic protein modification in bacteria.
Duronio RJ; Jackson-Machelski E; Heuckeroth RO; Olins PO; Devine CS; Yonemoto W; Slice LW; Taylor SS; Gordon JI
Proc Natl Acad Sci U S A; 1990 Feb; 87(4):1506-10. PubMed ID: 2406721
[TBL] [Abstract][Full Text] [Related]
19. Conformationally constrained [p-(omega-aminoalkyl)phenacetyl]-L-seryl-L-lysyl dipeptide amides as potent peptidomimetic inhibitors of Candida albicans and human myristoyl-CoA:protein N-myristoyl transferase.
Nagarajan SR; Devadas B; Zupec ME; Freeman SK; Brown DL; Lu HF; Mehta PP; Kishore NS; McWherter CA; Getman DP; Gordon JI; Sikorski JA
J Med Chem; 1997 May; 40(10):1422-38. PubMed ID: 9154965
[TBL] [Abstract][Full Text] [Related]
20. Genetic and biochemical studies of a mutant Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase, nmt72pLeu99-->Pro, that produces temperature-sensitive myristic acid auxotrophy.
Johnson DR; Duronio RJ; Langner CA; Rudnick DA; Gordon JI
J Biol Chem; 1993 Jan; 268(1):483-94. PubMed ID: 8416952
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
