112 related articles for article (PubMed ID: 9604866)
1. Reconstitution of glucotoxic HIT-T15 cells with somatostatin transcription factor-1 partially restores insulin promoter activity.
Harmon JS; Tanaka Y; Olson LK; Robertson RP
Diabetes; 1998 Jun; 47(6):900-4. PubMed ID: 9604866
[TBL] [Abstract][Full Text] [Related]
2. Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression.
Olson LK; Sharma A; Peshavaria M; Wright CV; Towle HC; Rodertson RP; Stein R
Proc Natl Acad Sci U S A; 1995 Sep; 92(20):9127-31. PubMed ID: 7568086
[TBL] [Abstract][Full Text] [Related]
3. Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15.
Moran A; Zhang HJ; Olson LK; Harmon JS; Poitout V; Robertson RP
J Clin Invest; 1997 Feb; 99(3):534-9. PubMed ID: 9022089
[TBL] [Abstract][Full Text] [Related]
4. Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells.
Harmon JS; Stein R; Robertson RP
J Biol Chem; 2005 Mar; 280(12):11107-13. PubMed ID: 15664999
[TBL] [Abstract][Full Text] [Related]
5. Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator.
Poitout V; Olson LK; Robertson RP
J Clin Invest; 1996 Feb; 97(4):1041-6. PubMed ID: 8613527
[TBL] [Abstract][Full Text] [Related]
6. Glucose rapidly and reversibly decreases INS-1 cell insulin gene transcription via decrements in STF-1 and C1 activator transcription factor activity.
Olson LK; Qian J; Poitout V
Mol Endocrinol; 1998 Feb; 12(2):207-19. PubMed ID: 9482663
[TBL] [Abstract][Full Text] [Related]
7. The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression.
Sharma A; Olson LK; Robertson RP; Stein R
Mol Endocrinol; 1995 Sep; 9(9):1127-34. PubMed ID: 7491105
[TBL] [Abstract][Full Text] [Related]
8. Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants.
Tanaka Y; Gleason CE; Tran PO; Harmon JS; Robertson RP
Proc Natl Acad Sci U S A; 1999 Sep; 96(19):10857-62. PubMed ID: 10485916
[TBL] [Abstract][Full Text] [Related]
9. The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site.
Serup P; Petersen HV; Pedersen EE; Edlund H; Leonard J; Petersen JS; Larsson LI; Madsen OD
Biochem J; 1995 Sep; 310 ( Pt 3)(Pt 3):997-1003. PubMed ID: 7575438
[TBL] [Abstract][Full Text] [Related]
10. The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells.
Watada H; Kajimoto Y; Umayahara Y; Matsuoka T; Kaneto H; Fujitani Y; Kamada T; Kawamori R; Yamasaki Y
Diabetes; 1996 Nov; 45(11):1478-88. PubMed ID: 8866550
[TBL] [Abstract][Full Text] [Related]
11. Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells.
Marshak S; Totary H; Cerasi E; Melloul D
Proc Natl Acad Sci U S A; 1996 Dec; 93(26):15057-62. PubMed ID: 8986763
[TBL] [Abstract][Full Text] [Related]
12. Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor.
Waeber G; Thompson N; Nicod P; Bonny C
Mol Endocrinol; 1996 Nov; 10(11):1327-34. PubMed ID: 8923459
[TBL] [Abstract][Full Text] [Related]
13. Functional regions of the homeodomain protein IDX-1 required for transactivation of the rat somatostatin gene.
Lu M; Miller C; Habener JF
Endocrinology; 1996 Jul; 137(7):2959-67. PubMed ID: 8770920
[TBL] [Abstract][Full Text] [Related]
14. Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein.
Olson LK; Redmon JB; Towle HC; Robertson RP
J Clin Invest; 1993 Jul; 92(1):514-9. PubMed ID: 8326016
[TBL] [Abstract][Full Text] [Related]
15. Suppression of transcription factor PDX-1/IPF1/STF-1/IDX-1 causes no decrease in insulin mRNA in MIN6 cells.
Kajimoto Y; Watada H; Matsuoka Ta; Kaneto H; Fujitani Y; Miyazaki J; Yamasaki Y
J Clin Invest; 1997 Oct; 100(7):1840-6. PubMed ID: 9312185
[TBL] [Abstract][Full Text] [Related]
16. Increase in PDX-1 levels suppresses insulin gene expression in RIN 1046-38 cells.
Seijffers R; Ben-David O; Cohen Y; Karasik A; Berezin M; Newgard CB; Ferber S
Endocrinology; 1999 Jul; 140(7):3311-7. PubMed ID: 10385428
[TBL] [Abstract][Full Text] [Related]
17. Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose.
Marshak S; Leibowitz G; Bertuzzi F; Socci C; Kaiser N; Gross DJ; Cerasi E; Melloul D
Diabetes; 1999 Jun; 48(6):1230-6. PubMed ID: 10342809
[TBL] [Abstract][Full Text] [Related]
18. Control of insulin gene expression by glucose.
Goodison S; Kenna S; Ashcroft SJ
Biochem J; 1992 Jul; 285 ( Pt 2)(Pt 2):563-8. PubMed ID: 1322137
[TBL] [Abstract][Full Text] [Related]
19. Trans-acting factor(s) confer glucose-responsive transcriptional regulation in the insulin gene.
Goodison S; Ashcroft SJ
Adv Exp Med Biol; 1997; 426():97-100. PubMed ID: 9544261
[No Abstract] [Full Text] [Related]
20. Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes.
Petersen HV; Serup P; Leonard J; Michelsen BK; Madsen OD
Proc Natl Acad Sci U S A; 1994 Oct; 91(22):10465-9. PubMed ID: 7937976
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]