180 related articles for article (PubMed ID: 9618435)
1. Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1: role in metabolic activation of acetaminophen and 2,6-dichlorobenzonitrile in mouse olfactory mucosal microsomes.
Gu J; Zhang QY; Genter MB; Lipinskas TW; Negishi M; Nebert DW; Ding X
J Pharmacol Exp Ther; 1998 Jun; 285(3):1287-95. PubMed ID: 9618435
[TBL] [Abstract][Full Text] [Related]
2. Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse.
Genter MB; Liang HC; Gu J; Ding X; Negishi M; McKinnon RA; Nebert DW
Biochem Pharmacol; 1998 Jun; 55(11):1819-26. PubMed ID: 9714300
[TBL] [Abstract][Full Text] [Related]
3. Targeted disruption of the olfactory mucosa-specific Cyp2g1 gene: impact on acetaminophen toxicity in the lateral nasal gland, and tissue-selective effects on Cyp2a5 expression.
Zhuo X; Gu J; Behr MJ; Swiatek PJ; Cui H; Zhang QY; Xie Y; Collins DN; Ding X
J Pharmacol Exp Ther; 2004 Feb; 308(2):719-28. PubMed ID: 14610229
[TBL] [Abstract][Full Text] [Related]
4. Biotransformation of coumarin by rodent and human cytochromes P-450: metabolic basis of tissue-selective toxicity in olfactory mucosa of rats and mice.
Zhuo X; Gu J; Zhang QY; Spink DC; Kaminsky LS; Ding X
J Pharmacol Exp Ther; 1999 Feb; 288(2):463-71. PubMed ID: 9918546
[TBL] [Abstract][Full Text] [Related]
5. Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation.
Xie F; Zhou X; Behr M; Fang C; Horii Y; Gu J; Kannan K; Ding X
Toxicol Appl Pharmacol; 2010 Nov; 249(1):101-6. PubMed ID: 20840855
[TBL] [Abstract][Full Text] [Related]
6. Baculovirus-mediated expression and characterization of rat CYP2A3 and human CYP2a6: role in metabolic activation of nasal toxicants.
Liu C; Zhuo X; Gonzalez FJ; Ding X
Mol Pharmacol; 1996 Oct; 50(4):781-8. PubMed ID: 8863822
[TBL] [Abstract][Full Text] [Related]
7. Metabolic activation of 2,6-dichlorobenzonitrile, an olfactory-specific toxicant, by rat, rabbit, and human cytochromes P450.
Ding X; Spink DC; Bhama JK; Sheng JJ; Vaz AD; Coon MJ
Mol Pharmacol; 1996 Jun; 49(6):1113-21. PubMed ID: 8649351
[TBL] [Abstract][Full Text] [Related]
8. Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene.
Hu J; Sheng L; Li L; Zhou X; Xie F; D'Agostino J; Li Y; Ding X
Drug Metab Dispos; 2014 Jan; 42(1):23-7. PubMed ID: 24104196
[TBL] [Abstract][Full Text] [Related]
9. cDNA cloning, heterologous expression, and characterization of mouse CYP2G1, an olfactory-specific steroid hydroxylase.
Hua Z; Zhang QY; Su T; Lipinskas TW; Ding X
Arch Biochem Biophys; 1997 Apr; 340(2):208-14. PubMed ID: 9143323
[TBL] [Abstract][Full Text] [Related]
10. CYP2A5-mediated activation and early ultrastructural changes in the olfactory mucosa: studies on 2,6-dichlorophenyl methylsulfone.
Franzén A; Carlsson C; Hermansson V; Lang M; Brittebo EB
Drug Metab Dispos; 2006 Jan; 34(1):61-8. PubMed ID: 16221755
[TBL] [Abstract][Full Text] [Related]
11. Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models.
Zhou X; D'Agostino J; Li L; Moore CD; Yost GS; Ding X
Drug Metab Dispos; 2012 Apr; 40(4):642-7. PubMed ID: 22228748
[TBL] [Abstract][Full Text] [Related]
12. The tissue-specific toxicity of methimazole in the mouse olfactory mucosa is partly mediated through target-tissue metabolic activation by CYP2A5.
Xie F; Zhou X; Genter MB; Behr M; Gu J; Ding X
Drug Metab Dispos; 2011 Jun; 39(6):947-51. PubMed ID: 21415250
[TBL] [Abstract][Full Text] [Related]
13. Bioactivation of the nasal toxicant 2,6-dichlorobenzonitrile: an assessment of metabolic activity in human nasal mucosa and identification of indicators of exposure and potential toxicity.
Xie F; D'Agostino J; Zhou X; Ding X
Chem Res Toxicol; 2013 Mar; 26(3):388-98. PubMed ID: 23360412
[TBL] [Abstract][Full Text] [Related]
14. Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas.
Miyazaki M; Yamazaki H; Takeuchi H; Saoo K; Yokohira M; Masumura K; Nohmi T; Funae Y; Imaida K; Kamataki T
Carcinogenesis; 2005 Nov; 26(11):1947-55. PubMed ID: 15958517
[TBL] [Abstract][Full Text] [Related]
15. Cytochrome P450 and steroid hydroxylase activity in mouse olfactory and vomeronasal mucosa.
Gu J; Dudley C; Su T; Spink DC; Zhang QY; Moss RL; Ding X
Biochem Biophys Res Commun; 1999 Dec; 266(1):262-7. PubMed ID: 10581200
[TBL] [Abstract][Full Text] [Related]
16. Evidence for induced microsomal bilirubin degradation by cytochrome P450 2A5.
Abu-Bakar A; Moore MR; Lang MA
Biochem Pharmacol; 2005 Nov; 70(10):1527-35. PubMed ID: 16183037
[TBL] [Abstract][Full Text] [Related]
17. Differential xenobiotic induction of CYP2A5 in mouse liver, kidney, lung, and olfactory mucosa.
Su T; He W; Gu J; Lipinskas TW; Ding X
Drug Metab Dispos; 1998 Aug; 26(8):822-4. PubMed ID: 9698299
[TBL] [Abstract][Full Text] [Related]
18. Nasal cytochrome P450 2A: identification, regional localization, and metabolic activity toward hexamethylphosphoramide, a known nasal carcinogen.
Thornton-Manning JR; Nikula KJ; Hotchkiss JA; Avila KJ; Rohrbacher KD; Ding X; Dahl AR
Toxicol Appl Pharmacol; 1997 Jan; 142(1):22-30. PubMed ID: 9007030
[TBL] [Abstract][Full Text] [Related]
19. Characterization of microsomal cytochrome P450-dependent monooxygenases in the rat olfactory mucosa.
Minn AL; Pelczar H; Denizot C; Martinet M; Heydel JM; Walther B; Minn A; Goudonnet H; Artur Y
Drug Metab Dispos; 2005 Aug; 33(8):1229-37. PubMed ID: 15879494
[TBL] [Abstract][Full Text] [Related]
20. Cell-specific expression of CYP2A5 in the mouse respiratory tract: effects of olfactory toxicants.
Piras E; Franzén A; Fernández EL; Bergström U; Raffalli-Mathieu F; Lang M; Brittebo EB
J Histochem Cytochem; 2003 Nov; 51(11):1545-55. PubMed ID: 14566026
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]